DNA Diagnostic and Research Laboratory
About Us
The DNA Diagnostic and Research Laboratory (DDRL) at KK Women’s and Children’s Hospital has been dedicated to providing high quality DNA-based testing for the molecular diagnosis, carrier testing and prenatal testing of genetic disorders, for over 10 years. Mutation detection methods used in the laboratory include automated capillary-based sequencing and genotyping, classic PCR, reverse dot blot hybridisation and Southern techniques. The laboratory currently provides DNA tests for over 10 genetic diseases, with continuing development of new tests and implementation of improved testing methodologies.
Hours of Operation
Monday - Friday : 8.00 am - 5.30 pm
Saturday : 8.00 am - 12.30 pm
Accreditations
SAC-SINGLAS Accredited
Professional Staff
Laboratory Staff
- Dr Law Hai Yang, DPhil, Chief Scientific Officer
- Dr Tan Yuen Ming, MPhil, Scientific Officer
- Ms Yoon Chui Sheun, BSc, Laboratory Manager
Clincal Staff
- Dr Angeline Lai, MBBS, MRCP(Paeds), Consultant and Head, Genetics Service
- Clin Prof Ivy Ng, MBBS, MMed (Paeds), FRCP, FAMS, Snr Consultant, Genetics Service
- Dr Tan Ee Shien, MBBS, MRCP (Paeds), Associate Consultant, Genetics Service
- Dr Teo Siak Hong, MBBS, MMed (Paeds), FAMS, Visiting Consultant, Genetics Service
How to Contact Us
DNA Diagnostic and Research Laboratory
KK Women’s and Children’s Hospital
Mail: 100 Bukit Timah Road, Singapore 229899
Phone: (65) 6394-1395/6
Fax: (65) 6394-1397
Email:
Law.Hai.Yang@kkh.com.sg
Tan.Yuen.Ming@kkh.com.sg
Yoon.Chui.Sheun@kkh.com.sg
Note: The laboratory does not provide direct patient consultation. The tests may only be ordered through a physician or genetic counsellor.
Alpha-thalassaemia
- DNA Analysis for local common α-thalassaemia mutations (will pick up 99% of α-thalassaemia alleles in Singapore)
- Sequencing α1 and α2-globin genes
Angelman syndrome (AS)
- DNA Methylation Analysis
- FISH Analysis
Beta-thalassaemia
- DNA Analysis for local common β-thalassaemia mutations (will pick up 96% of β-thalassaemia alleles in Singapore)
- Sequencing β-globin genes
Fragile X syndrome
Huntington Disease (HD)
Myotonic Dystrophy
Prader-Willi syndrome (PWS)
- DNA Methylation Analysis
- FISH Analysis
Spinal Muscular Atrophy (SMA)
- DNA Analysis for homozygous deletion of SMN1 gene
- Carrier testing
Spinocerebellar ataxia (SCA)
Kennedy Disease
Achondroplasia
- Alpha-thalassaemia
- Angelman syndrome (AS)
- Beta-thalassaemia
- Fragile X syndrome
- Myotonic Dystrophy
- Prader-Willi syndrome (PWS)
- Spinal Muscular Atrophy (SMA)
Blood Specimens:
EDTA (purple) tubes; Adult: 3-6 mls, Child: 1-3 mls, Infant: 1 mls
Fetal Specimens:
We require that the referring centre contact us regarding prenatal cases prior to submitting any samples.
For the most accurate fetal results, analysis of family members is often required. For autosomal recessive conditions, blood specimens should be submitted from both parents and the affected sibling for molecular analysis. For autosomal dominant or X-linked conditions, the high risk parent and the affected relative should be studied. Some disorders may require analysis of additional family members for precise interpretation of fetal results.
Fetal specimens should be clearly labelled with the mother's full name, type of fetal sample (CVS or amnio), and if available, the fetal sex determined by cytogenetic data. Maternal blood is required for all prenatal tests to rule out contamination and sample switch. Clearly indicate if ordering cytogenetics or biochemical studies in addition to DNA
- Amniotic Fluid: 20mls
- Chorionic Villi: 10mg
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Please contact the laboratory for up-to-date test prices and methods of payment.
DNA Diagnostic and Research Laboratory
KK Women’s and Children’s Hospital
Mail: 100 Bukit Timah Road, Singapore 229899
Phone: (65) 6394-1395/6
Fax: (65) 6394-1397
Email:
Law.Hai.Yang@kkh.com.sg
Tan.Yuen.Ming@kkh.com.sg
Yoon.Chui.Sheun@kkh.com.sg
Note: The laboratory does not provide direct patient consultation. The tests may only be ordered through a physician or genetic counsellor.