JAZF1-SUZ12, YWHAE-NUTM2A/B and ZC3H7B-BCOR Panel for Endometrial Stroma Sarcoma (DISCONTINUED)

Test Code:

XXXXX

Synonym(s):

Specimen Container

Specimen Requirement

1. Formalin-Fixed Paraffin-Embedded block or
2. 5x unstained sections and 1 x H&E slide.

Specimen Storage / Transport

Method

Orderable as STAT?

Turn Around Time

7 Working days

Reference Value(s)

Testing Laboratory Location

KKH

Laboratory

Molecular Histopathology

Contact Number

6394 1402

Day and Time Performed

Mon – Fri: 0800 hrs – 1700 hrs

Orderable on CPOE?

Downtime Form

Molecular Histopathology

Additional Information

This test tests for the presence of gene fusions found in endometrial stromal sarcomas (ESS).
YWHAE-NUTM2A/B and ZC3H7B-BCOR gene fusions are described in high-grade ESS, while JAZF1-SUZ12 gene fusion is the most common genetic alteration found in low grade ESS. The absence of the gene fusions does not exclude diagnosis.
In addition, YWHAE-NUTM2A/B and ZC3H7B-BCOR gene fusions are also found in cases of clear cell sarcomas of the kidney

Expected results:
YWHAE-NUTM2A/B gene fusion is detected/not detected.
JAZF1-SUZ12 gene fusion is detected/not detected.
ZC3H7B-BCOR gene fusion is detected/not detected.

If all three fusions are not detected, we will report on the detection of housekeeping gene as a control for RNA integrity.

Negative (RNA integrity is acceptable as checked by housekeeping gene) Inconclusive (RNA quality is not good enough)

The molecular test result must always be correlated with clinical and histopathological findings by an appropriately trained, qualified and experienced pathologist.

Quality Assurance: Internal Quality Audit (KKH DPLM)

HT0201

Change History Notes

Others

Keywords

JAZF1-SUZ12, YWHAE-NUTM2A/B and ZC3H7B-BCOR Panel for Endometrial Stroma Sarcoma (DISCONTINUED) XXXXX

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