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Assoc Prof Wang Xiaomeng

Assoc Prof Wang Xiaomeng

​BSc, PhD

Profile

​Dr Xiaomeng Wang is an Associate Professor at the Centre for Vison Research, Duke-NUS Medical School. Prior to this appointment, Dr. Wang worked as an Associate Professor at the Lee Kong Chian School of Medicine, Nanyang Technological University Singapore. Dr. Wang obtained her BSc. in Biology at Beijing Normal University, China and her PhD in Genetics at Newcastle University, UK. She subsequently underwent post-doctoral training at Manchester University and University College London, UK.

Education

  • ​PhD (2006)
  • BSc (2000)

Professional Appointments and Committee Memberships

  • ​Member, The Association for Research in Vision and Ophthalmology (ARVO) (2008 - 2021)
  • Principal Investigator, Institute of Molecular and Cell Biology, A*STAR

Awards

  • ​UK Overseas Research Scholarship (2001)
  • London Business School Bursary (2008)
  • Wellcome Trust Advanced Course Bursary (2009)
  • Koh Boon Hwee Scholars Award (2016)

Research Interests

  • ​​Pathophysiology of fibrovascular diseases
  • Molecular and cellular mechanisms of fibrovascular progression
  • Biomarkers for early diagnosis, prognosis, and evaluation of treatment outcome
  • Ocular drug delivery

Publications

  1. ​Tan WY*, Kong ZQ, Tan WR, Toh JH, Wee WK, Teo ML, Wang X, Tan NS. High glucose restrains acetylcholine-induced keratinocyte EMT is mitigated by p38/STAT inhibition. December 2020. Journal of Investigative Dermatology. DOI: 10.1016/j.jid.2020.10.026 [IF: 7.143].

  2. Menon N, Su C, Pang KT*, Phua ZJ, Tay HM, Dalan R, Wang X, Li H, Hou H. Recapitulating Atherogenic Flow Disturbances and Vascular Inflammation in a Perfusable 3D Stenosis Model. July 2020.Biofabrication 12(4). DOI: 10.1088/1758-5090/aba501 [IF: 8.213].

  3. Liu C, Teo M, Pek SLT, Wu X, Leong ML, Tay HM, Hou HW, Ruedl C, Moss SE, Greenwood J, Tavintharan S, Hong W, Wang X. A Multifunctional Role of Leucine-Rich α-2-Glycoprotein 1 in Cutaneous Wound Healing Under Normal and Diabetic Conditions. Diabertes.2020 Nov; 69(11): 2467-2480. [IF:7.372]

  4. Kirkby N, Raouf J, Shala BA, Liu B, Mazi SI, Edin ML, Chambers MG, Korotkova M, Wang X, Wahli W, Zeldin DC, Nüsing R, Zhou Y, Jakobsson PJ, Mitchell JA. Mechanistic definition of the cardiovascular mPGES1/COX-2/ADMA axis. Cardiovasc Res. 2020 Oct 1;116(12):1972-1980. doi: 10.1093/cvr/cvz290. [IF: 8.168].

  5. Ho SZ, Kwan YP , Qiu B, Tan A, Murray HL, Barathi VA, Tan NS, Cheung CMG, Wong TY, Wahli W, Wang X. Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice. Int. J. Mol. Sci. 2020, 21(12), 4403; https://doi.org/10.3390/ijms21124403. [IF: 4.556].

  6. Ju J, Tian Y, Kang J, Chia R, Chang H, Bai Y, Hsieha C, Xu C, Wang X, Liu Q. Surface Enhanced Raman Spectroscopy based Biosensor with a Low-cost Microneedle Array for Minimally Invasive In Situ Glucose Measurements. ACS Sens. 2020, 5, 6, 1777–1785: May 19, 2020 [IF: 6.944].

  7. Tan WY, Sng MK, Cheng HS, Low ZS, Leong JJ, Chua D, Tan HP, Chan ST, Yip YS, Lee YY, Pal M, Wang X, Wahli W, Tan NS. Deficiency in fibroblast PPARβ/δ reduces non-melanoma skin cancers in mice. Cell Death & Differentiation volume 27, pages2668–2680(2020) [IF: 10.717].

  8. Lio D, Chia R, Kwek M, Wiraja C, Chang H, Khadir SMA, Wang X*, Becker DL*, Xu C*, Temporal Pressure Enhanced Topical Drug Delivery through Micropore Formation. Science Advances. 2020 May 29;6(22):eaaz6919. doi: 10.1126/sciadv.aaz6919. [IF: 13.116].

  9. Liu C, Lim ST, Teo M, Tan M, Kulkarni MD, Qiu B, Li A, Lal S, dos Remedios CG, Tan NS, Wahli W, Ferenczi MA, Song W, Hong W, Wang X. Collaborative regulation of LRG1 by TGFβ1 and PPARβ/δ modulates chronic pressure-overload-induced cardiac fibrosis. Circulation: Heart Failure. 2019 Dec;12(12):e005962. doi: 10.1161/CIRCHEARTFAILURE.119.005962. [IF: 6.526].

  10. Xue K, Zhao X, Zhang Z, Qiu B, Tan QSW, Ong KH, Liu Z, Parikh BH, Barathi AV, Yu W, Wang X, Lingam G, Hunziker W, Su X, Loh XJ. Sustained delivery of anti-VEGFs from thermogel depots inhibits angiogenesis without the need for multiple injections. Biomaterials Science. 2019 Aug 22. doi: 10.1039/c9bm01049a. [IF: 6.183].

  11. Qiu B, Tan A, Barathi AV, Li Y, Liu C, Murray H, Cheng W, Busoy JM, Chen QY, Sistla S, Hunziker W, Cheung CMG, Wong TY, Hong W, Luesch H, Wang X. Apratoxin S4 inspired by a marine natural product, a new treatment option for ocular angiogenic diseases. IOVS. 2019;60:3254–3263. [IF: 3.303].

  12. Njah K, Chakraborty S, Qiu B, Arumugam S, Raju A, Pobatti A, Lakshmanan M, Tergaonkar V, Thibault G, Wang X*, Hong W*. A role of Agrin in maintaining the stability of Vascular endothelial growth factor receptor-2 during tumor angiogenesis. Cell Report.  2019 July 23; 28 (4): 949-965. [IF: 8.109]. 

  13. Than A, Liu C, Cheng H, Duong PK, Xu C*, Wang X*, Chen P*. Selfimplantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery. Nature Communications. (2018) 9:4433 | DOI: 10.1038/s41467-018-0698. [IF: 13.691].

  14. Lim JCW, Kwan JYL, Tan MS, Tan M, Wahli W, Wang X. PPARβ/δ-deficiency leads to increased melanoma metastasis. International Journal of Molecular Science. 2018 Oct; 19(10): 2860.

  15. Lio D, Liu C, Wiraja C, Qiu B, Fhu CW, Wang X*, Xu C* Molecular beacon-gold nanosensors for Leucine-rich alpha-2-glycoprotein-1 (Lrg1) detection in pathological angiogenesis. ACS Sensor Aug 10, 2018; [IF: 6.944]. 

  16. Sng MK, Chan JSK, Teo Z, Phua T, Tan EHP, Wee JWK, Koh NJN, Tan CK, Chen JP, Pal M, Tong BMK, Tnay YL, Ng XR, Zhu P, Chiba S, Wang X, Wahli W, TAN NS. Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression. Cell discovery April 3, 2018. [IF: 11.981].

  17. Song WH, Fhu CW, Ang KW, Liu CH, Nurul ABJ, Lio CS, Abraham S, Moss SE, Greenwood J, Hong WJ, Wang X. The foetal mouse metatarsal bone explant as a model of angiogenesis. Nature Protocols. 2015 10,1459–1473. [IF: 15.086].

  18. Pek SL, Tavintharan S, Wang BoX, Chi Lim S, Woon K, Ying Yeoh L, Ng X, Liu J, Fang Sum C. Elevation of a novel angiogenic factor, Leucine-Rich-α2-Glycoprotein (LRG1), is associated with arterial stiffness, endothelial dysfunction and Peripheral Arterial Disease in patients with Type 2 Diabetes. J Clin Endocrinol Metab. 2015 Jan 30:jc20143855. [IF: 6.2].

  19. Wang X, Abraham S, McKenzie JAG, Jeffs N, Swire M, Lange CAK, Luhmann U, Bainbridge J, Zhai Z, Arthur H, Moss SE, Greenwood J. Lrg1 promotes angiogenesis by modulating endothelial TGFβ signaling. Nature. 2013 July 18; 499 (7458):306-311. [IF: 42.778].

  20. Wang X, Harris RE, Bayston, LJ, Ashe HL. Type IV collagens regulate BMP signalling in Drosophila. Nature. 2008. 455: 72-77. [IF: 42.778].

Research Trials

  • ​Translational Asian Age-related Macular Degeneration Program (2018-2023)
  • DYNAMO: Diabetes Study in Nephropathy and Other Microvascular Complications (2017-2022)
  • SERI-IMCB Programme In Retinal Angiogenic Diseases (2015-2021)
  • Updated on