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Asst Prof Sangrithi Mahesh Nataraj

Mahesh Nataraj Sangrithi

Asst Prof Sangrithi Mahesh Nataraj


Specialty: Obstetrics & Gynaecology

Sub-specialties: Reproductive Medicine, Reproductive Surgery

Clinical Appointments

  • Consultant Reproductive Medicine KK Women's and Children's HospitalKK Women's and Children's Hospital


Dr Sangrithi graduated from St. George’s Hospital Medical School, University of London in 1999 with distinction in Surgery. He completed specialist and sub-speciality training at University College London Hospitals, London and is an RCOG accredited subsecialist in Reproductive Medicine and Surgery. He subsequently was appointed as Consultant gynaecologist at Addenbrooke’s Hospital in Cambridge, before relocating to Singapore.

Alongside his clinical activity Dr. Sangrithi has developed an program of research which focusses on reproductive biology, stem cells and early embryonic development. He received his PhD in 2005 from the University of Cambridge. Dr. Sangrithi has received numerous research grants, prior to joining SingHealth as Clinician–Scientist. He has recently been awarded the prestigious NMRC CSA-investigator grant ($1.25M).


  • MBBS (London)
  • MRCOG (RCOG, London)
  • PhD (Cambridge)
  • CCT and CCSST - Reproductive medicine and surgery (RCOG, London)

Professional Appointments and Committee Memberships

  • Asst Professor, Duke-NUS
  • Consultant, Department of Reproductive Medicine, KKH
  • Member, SingHealth Procedural Safety Workgroup


  • NIHR TCC Clinical Lectureship (University College London, UK)
  • Walport Academic Clinical Fellowship (University College London, UK)
  • CRUK Clinical Research Fellowship
  • Cambridge Commonwealth Trust Scholarship and ORS Award

Research Interests

  • Reproductive Biology and Stem cells
  • Sex chromosome infertility
  • Early embryonic development

Publications and Research Trials

  • Sangrithi M, Turner JMA. Mammalian X chromosome dosage compensation: perspectives from the germ line. Bioessays 2018 (in press)
  • Sangrithi M, Royo H, Mahadeviah SK, Ojarikre O, Sesay A, Peters AHFM, Stadler MB, Turner JMA. Non-Canonical and Sexually Dimorphic X Dosage Compensation States in the Mouse and Human Germline. Developmental Cell. 2017.
  • Grant J, Mahadevaiah SK, Khil P, Sangrithi MN, Royo H, Duckworth J, McCarrey JR, VandeBerg JL, Renfree MB, Taylor W, Elgar G, Camerini-Otero RD, Gilchrist MJ, Turner JM. Rsx is a metatherian RNA with Xist-like properties in X-chromosome inactivation. Nature. 2012 Jul 12;487(7406):254-8
  • F. Odejinmi, M. Sangrithi, O Olowu. Role for Operative Laparoscopy as the Mainstay Operative modality in the management of haemodynamically unstable patients with Ectopic pregnancy. J Minim Invasive Gynecol. 2011 Mar-Apr;18(2):179-83
  • M. Sangrithi, J. Bernal, M. Madine, A. Philpott, J. Lee, W. Dunphy, AR Venkitaraman. Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome. Cell 2005 121:887-898.

Research Trials