Translational research for childhood brain and solid tumours is critical in finding new and better ways to treat these diseases, while trying to minimize the harm caused by drugs, radiation or surgery. This requires an integrated approach and a high degree of collaboration between doctors and scientists. In this area, KKH, with its high volume of patients, works in cooperation with research centres within the SingHealth Duke-NUS cluster.
Our clinician-scientists and researchers have a particular focus on paediatric brain tumours, neuroblastoma, paediatric renal tumours, ovarian tumours and sarcomas. Existing local research collaborations involve the National Cancer Centre Singapore, Duke-NUS Graduate Medical School, and the National University of Singapore. Current overseas collaborations include the Hospital for Sick Children, Toronto, and St Jude Children’s Research Hospital, Memphis TN.
Using a translational research pipeline, we adopt a targeted approach to advance scientific findings from basic, to pre-clinical and early clinical development, and on to early phase clinical trials, for various paediatric brain and solid tumours. Given the wide heterogeneity of the diseases of interest, there is tremendous scope for developing personalized medical management informed by specific and precise patient and tumour biology to optimize treatment, thereby improving outcomes.
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