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Microsatellite Instability (MSI) PCR Testing

Test Code:




Specimen Container

Specimen Requirement

1. Formalin-Fixed Paraffin-Embedded block or
2. 10x unstained sections and 1 corresponding H&E slide.
Matching normal and tumour tissue required.
Tissue must be non-necrotic, non-cauterised, and must not have undergone acid-based decalcification. Improper storage conditions may additionally compromise nucleic acid integrity.

Specimen Storage / Transport



Orderable as STAT?


Turn Around Time

3 working days; Batch run every Thursday

Reference Value(s)

Testing Laboratory Location



Molecular Histopathology

Contact Number

6394 1402

Day and Time Performed

Mon – Fri: 0800 hrs– 1700 hrs

Orderable on CPOE?


Downtime Form

Additional Information

This test complements IHC for the 4 DNA mismatch repair (MMR) proteins. It compares the allelic profiles of five mononucleotide microstatellite markers - NR-21, BAT-26, BAT-25, NR-24 and MONO-27- generated by amplification of DNA from matching normal and test samples.
The MSI test is part of the Lynch Disease Screening Programme at KKH, which is described in “Saving lives, changing futures”.

Expected Test Result: MSI-stable; MSI-low (1 shift); MSI-high (2 or more shifts)

Test is set up on Mondays.

The molecular test result must always be correlated with clinical and histopathological findings by an appropriately trained, qualified and experienced pathologist.
Quality Assurance: CAP (MSI)

Change History Notes



Microsatellite Instability (MSI) PCR Testing HT0205

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