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Assoc Prof Monisha Esther Nongpiur

Assoc Prof Nongpiur Monisha Esther

​MBBS, MD, PhD

Academic Appointments

  • Associate Professor SingHealth Duke-NUS Ophthalmology ＆ Visual Sciences Academic Clinical Programme

Profile

Assoc Prof Monisha Nongpiur, is a Clinician Scientist and Junior Principal Investigator at the Singapore Eye Research Institute. She balances both clinical and research related work in Glaucoma, and her main clinical research interest is primary angle closure glaucoma.  Her research is focused on a better understanding of the clinical course, risk factors/disease mechanisms, genetics, and also to develop risk assessment models for the condition.

She currently holds academic appointment at Duke-NUS Medical School, Singapore as Associate Professor, Ophthalmology and Visual Science Academic Clinical Program. Dr Nongpiur is a member of the Associate Advisory Board of the World Glaucoma Association and the WGA Education committee.

Education

  • PhD (2015)
  • MD Ophthalmology (2007)
  • MBBS (2002)

Professional Appointments and Committee Memberships

  • Member, Education committee, World Glaucoma Association (2018 – present)
  • Member, Associate Advisory Board, World Glaucoma Association (2017 – present)
  • Member, SERI Scientific Review Panel (2011 – present)
  • Member, Delhi Ophthalmology Society (2005 – present)

Awards

  • International Glaucoma Panel Mentorship programme (2018)
  • Transition Award, National Medical Research Council, Singapore (2016)
  • Travel Grant Award, Asia-ARVO (2015)
  • Outstanding Young Researcher Award, Singapore Eye Research Institute (2014)
  • Publish! Award (Medical Research), SingHealth (2013)
  • Travel Grant Award, The Association for Research in Vision and Ophthalmology (ARVO) (2012)
  • Best Oral Presentations Award, 2nd Annual Graduate Scientific Congress, National University of Singapore (2012)
  • Best Paper NHG Eye Institute 2nd International Ophthalmology Congress, Singapore (2009)

Research Interests

  • Ocular imaging
  • Visual field progression
  • Development of risk assessment models for angle closure glaucoma
  • Understanding the genetic basis of the diseaseglaucoma

Publications

  1. Nongpiur ME, Khor CC, Cheng CY, Husain R, Boey PY, Chew A, Ho CL, Wong TT, Perera S, Wong TY, Vithana EN, Aung T. Integration of Genetic and Biometric Risk Factors for Detection of Primary Angle Closure Glaucoma. Am J Ophthalmol. 2019 Dec;208:160-165
  2. Husain R, Do T, Lai J, Kitnarong N, Nongpiur ME, Perera SA, Ho CL, Lim SK, Aung T. Efficacy of Phacoemulsification Alone vs Phacoemulsification With Goniosynechialysis in Patients With Primary Angle-Closure Disease: A Randomized Clinical Trial. JAMA Ophthalmol. 2019
  3. Nongpiur ME, Cheng CY, Duvesh R, Vijayan S, Baskaran M, Khor CC, Allen J,Kavitha S, Venkatesh R, Goh D, Husain R, Boey PY, Quek D, Ho CL, Wong TT, Perera S, Wong TY, Krishnadas SR, Sundaresan P, Aung T, Vithana EN. Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci in Patients with Early Stages of Angle-Closure Disease. Ophthalmology. 2018 Jan 5 [Epub ahead of print]
  4. Verma S, Nongpiur ME, Atalay E, Wei X, Husain R, Goh D, Perera SA, Aung T. Visual Field Progression in Patients with Primary Angle-Closure Glaucoma Using Pointwise Linear Regression Analysis. Ophthalmology. 2017; 124(7):1065-1071
  5. Tun TA, Atalay E, Baskaran M, Nongpiur ME, Htoon HM, Goh D, Cheng CY, Perera SA, Aung T, Strouthidis NG, Girard MJA. Association of Functional Loss With the Biomechanical Response of the Optic Nerve Head to Acute Transient Intraocular Pressure Elevations. JAMA Ophthalmol. 136(2):184-192
  6. Atalay E, Nongpiur ME, Yap SC, Wong TT, Goh D, Husain R, Perera SA, Aung T. Pattern of Visual Field Loss in Primary Angle-Closure Glaucoma Across Different Severity Levels. Ophthalmology. 2016 Sep;123(9):1957-64
  7. Lee MC, Shei W, Chan AS, Chua BT, Goh SR, Chong YF, Hilmy MH, Nongpiur ME, Baskaran M, Khor CC, Aung T, Hunziker W, Vithana EN. Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function. Hum Mol Genet. 2017 Oct 15;26(20):4011-4027.
  8. Nongpiur ME, Aung T. Mechanisms underlying acute angle closure. Clin Exp Ophthalmol. 2017 May;45(4):331-332
  9. Nongpiur ME, Aboobakar IF, Baskaran M, Narayanaswamy A, Sakata LM, Wu R, Atalay E, Friedman DS, Aung T. Association of Baseline Anterior Segment Parameters With the Development of Incident Gonioscopic Angle Closure. JAMA Ophthalmol. 2017 Mar 1;135(3):252-258
  10. Khor CC, Do T, Jia H, Nakano M, George R, Abu-Amero K, Duvesh R, Chen LJ, Li Z, Nongpiur ME, Perera SA, Qiao C, Wong HT, Sakai H, Barbosa de Melo M, Lee MC,Chan AS, Azhany Y, Dao TL, Ikeda Y, Perez-Grossmann RA, Zarnowski T, Day AC,Jonas JB, Tam PO, Tran TA, Ayub H, Akhtar F, Micheal S, Chew PT, Aljasim LA, DadaT, Luu TT, Awadalla MS, Kitnarong N, Wanichwecharungruang B, Aung YY,Mohamed-Noor J, Vijayan S, Sarangapani S, Husain R, Jap A, Baskaran M, Goh D, Su DH, Wang H, Yong VK, Yip LW, Trinh TB, Makornwattana M, Nguyen TT, LeuenbergerEU, Park KH, Wiyogo WA, Kumar RS, Tello C, Kurimoto Y, Thapa SS, Pathanapitoon K,Salmon JF, Sohn YH, Fea A, Ozaki M, Lai JS, Tantisevi V, Khaing CC, Mizoguchi T, Nakano S, Kim CY, Tang G, Fan S, Wu R, Meng H, Nguyen TT, Tran TD, Ueno M, Martinez JM, Ramli N, Aung YM, Reyes RD, Vernon SA, Fang SK, Xie Z, Chen XY, Foo JN, Sim KS, Wong TT, Quek DT, Venkatesh R, Kavitha S, Krishnadas SR, Soumittra N,Shantha B, Lim BA, Ogle J, de Vasconcellos JP, Costa VP, Abe RY, de Souza BB, Sng CC, Aquino MC, Kosior-Jarecka E, Fong GB, Tamanaja VC, Fujita R, Jiang Y, Waseem N, Low S, Pham HN, Al-Shahwan S, Craven ER, Khan MI, Dada R, Mohanty K, Faiq MA, Hewitt AW, Burdon KP, Gan EH, Prutthipongsit A, Patthanathamrongkasem T,Catacutan MA, Felarca IR, Liao CS, Rusmayani E, Istiantoro VW, Consolandi G,Pignata G, Lavia C, Rojanapongpun P, Mangkornkanokpong L, Chansangpetch S, Chan JC, Choy BN, Shum JW, Than HM, Oo KT, Han AT, Yong VH, Ng XY, Goh SR, Chong YF, Hibberd ML, Seielstad M, Png E, Dunstan SJ, Chau NV, Bei J, Zeng YX, Karkey A, Basnyat B, Pasutto F, Paoli D, Frezzotti P, Wang JJ, Mitchell P, Fingert JH, Allingham RR, Hauser MA, Lim ST, Chew SH, Ebstein RP, Sakuntabhai A, Park KH, Ahn J, Boland G, Snippe H, Stead R, Quino R, Zaw SN, Lukasik U, Shetty R, Zahari M, Bae HW, Oo NL, Kubota T, Manassakorn A, Ho WL, Dallorto L, Hwang YH, Kiire CA, Kuroda M, Djamal ZE, Peregrino JI, Ghosh A, Jeoung JW, Hoan TS, Srisamran N, Sandragasu T, Set SH, Doan VH, Bhattacharya SS, Ho CL, Tan DT, Sihota R, Loon SC, Mori K, Kinoshita S, Hollander AI, Qamar R, Wang YX, Teo YY, Tai ES, Hartleben-Matkin C, Lozano-Giral D, Saw SM, Cheng CY, Zenteno JC, Pang CP, Bui HT, Hee O, Craig JE, Edward DP, Yonahara M, Neto JM, Guevara-Fujita ML, Xu L, Ritch R, Liza-Sharmini AT, Wong TY, Al-Obeidan S, Do NH, Sundaresan P, Tham CC, Foster PJ, Vijaya L, Tashiro K, Vithana EN, Wang N, Aung T. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nat Genet. 2016 May;48(5):556-62
  11. Trikha S, Saffari E, Nongpiur ME, Baskaran M, Ho H, Li Z, Tan PY, Allen J, Khor CC, Perera SA, Cheng CY, Aung T, Vithana E. A Genetic Variant in TGFBR3-CDC7 Is Associated with Visual Field Progression in Primary Open-Angle Glaucoma Patients from Singapore. Ophthalmology 2015; Dec;122(12):2416-22
  12. Nongpiur ME, Khor CC, Jia H, Cornes BK, Chen LJ, Qiao C, Nair KS, Cheng CY, Xu L, George R, Tan D, Abu-Amero K, Perera SA, Ozaki M, Mizoguchi T, Kurimoto Y, Low S, Tajudin LSA, Ho CL, Tham CCY, Soto I, Chew PTK, Wong HT, Shantha B, Kuroda M, Osman EA, Tang G, Fan S, Meng H, Wang H, Feng B, Yong VHK, Ting SML, Li Y, Wang YX, Li Z, Lavanya R, Wu RY, Zheng YF, Su DH, Loon SC, Yong VKY, Allingham RR, Hauser MA, Soumittra N, Ramprasad VL, Waseem N, Yaakub A, Chia KS, Kumaramanickavel G, Wong TT, How AC, Chau TNB, Simmons CP, Bei JX, Zeng YX, Bhattacharya SS, Zhang M, Tan DT, Teo YY, Al-Obeidan SA, Hon DN, Tai ES, Saw SM, Foster PJ, Vijaya L, Jonas JB, Wong TY, John SWM, Pang CP, Vithana EN, Wang N, Aung T. ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma. PLoS genetics 2014; 10(3)
  13. Nongpiur ME, Haaland BA, Perera SA, Friedman DS, He M, Sakata LM, Baskaran M, Aung T. Development of a score and probability estimate for detecting angle closure based on anterior segment optical coherence tomography. American journal of ophthalmology 2014; 157(1):32-38.e1
  14. Wei X, Nongpiur ME, de Leon MS, Baskaran M, Perera SA, How AC, Vithana EN, Khor CC, Aung T. Genotype-phenotype correlation analysis for three primary angle closure glaucoma-associated genetic polymorphisms. Investigative ophthalmology & visual science 2014; 55(2):1143-1888
  15. Yong KL, Gong T, Nongpiur ME, How AC, Lee HK, Cheng L, Perera SA, Aung T. Myopia in asian subjects with primary angle closure: implications for glaucoma trends in East Asia. Ophthalmology 2014; 121(8):1566-1717
  16. Nongpiur ME, Haaland BA, Friedman DS, Perera SA, He M, Foo LL, Baskaran M, Sakata LM, Wong TY, Aung T. Classification algorithms based on anterior segment optical coherence tomography measurements for detection of angle closure. Ophthalmology 2013; 120(1):48-54
  17. Nongpiur ME, Gong T, Lee KW, Perera SA, Cheng L, Foo LL, He M, Friedman DS, Aung T. Subgrouping of primary angle-closure suspects based on anterior segment optical coherence tomography parameters. Ophthalmology 2013; 120(12):2525-2313
  18. Foo LL, Nongpiur ME, Allen JC, Perera SA, Friedman DS, He M, Cheng CY, Wong TY, Aung T. Determinants of angle width in Chinese Singaporeans. Ophthalmology 2012; 119(2):278-282
  19. Vithana EN, Khor CC, Qiao C, Nongpiur ME, George R, Chen LJ, Do T, Abu-Amero K, Huang CK, Low S, Tajudin LSA, Perera SA, Cheng CY, Xu L, Jia H, Ho CL, Sim KS, Wu RY, Tham CCY, Chew PTK, Su DH, Oen FT, Sarangapani S, Soumittra N, Osman EA, Wong HT, Tang G, Fan S, Meng H, Huong DTL, Wang H, Feng B, Baskaran M, Shantha B, Ramprasad VL, Kumaramanickavel G, Iyengar SK, How AC, Lee KY, Sivakumaran TA, Yong VHK, Ting SML, Li Y, Wang YX, Tay WT, Sim X, Lavanya R, Cornes BK, Zheng YF, Wong TT, Loon SC, Yong VKY, Waseem N, Yaakub A, Chia KS, Allingham RR, Hauser MA, Lam DSC, Hibberd ML, Bhattacharya SS, Zhang M, Teo YY, Tan DT, Jonas JB, Tai ES, Saw SM, Hon DN, Al-Obeidan SA, Liu J, Chau TNB, Simmons CP, Bei JX, Zeng YX, Foster PJ, Vijaya L, Wong TY, Pang CP, Wang N, Aung T. Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. Nature genetics 2012; 44(10):1142-1666
  20. Nongpiur ME, He M, Amerasinghe N, Friedman DS, Tay WT, Baskaran M, Smith SD, Wong TY, Aung T. Lens vault, thickness, and position in Chinese subjects with angle closure. Ophthalmology 2011; 118(3):474-499

Research Trials

  • ​Bayesian Machine Learning Approach to Identify Markers of Progression in Primary Angle Closure Glaucoma (2020 – present)
  • Investigating the Genetic and Phenotypic Architecture of Advanced Primary Angle Closure Glaucoma for Stratified Disease Management (2019 – present)
  • The effect of intraocular pressure lowering medication on ocular blood flow: An Optical Coherence Tomography Angiography study (2016 – present)
  • Characterizing the Role of Iris Surface Features in Iris Sponginess and their Relevance to Angle-Closure Glaucoma (2016 – present)
  • Investigating the Role of Inflammation in Primary Angle Closure Glaucoma (2016 – present)
  • The Asia Primary Tube versus Trab (TVT) Study (2016 – present)
  • Whole exome sequencing to identify actionable mutations causative of primary angle closure glaucoma (2015 – present)
  • Discrete Event Simulation of a Primary Angle Closure Glaucoma Model in Singapore (2015 – present)
  • A Study to Profile Expression Levels of Glaucoma Associated Genes in Human Ocular Tissues (2012 – present)
  • Investigating the Genetic basis of Glaucoma (2011 – present)
  • Accurate Phenotyping of Angle Closure Glaucoma (2009 – present)
  • Using Biomechanics to Predict Glaucomatous Vision Loss Progression in Humans (2014 -present)
  • Development of a novel test for assessing photoreceptor dysfunction in patients with glaucoma using the pupillary light reflex (2013 – present)
  • Identification of Genetic biomarkers for disease progression in Angle Closure (2013 – 2016)

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