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Assoc Prof Joanne Ngeow Yuen Yie

Assoc Prof Ngeow Yuen Yie Joanne

MBBS (Hons), MRCP (UK), MMed (Spore), FAMS, MPH

Senior Consultant

National Cancer Centre Singapore

Specialty: Medical Oncology, Medical Oncology

Clinical Interest: Cancer Genomic Medicine, Upper Gastrointestinal, Colorectal

Conditions Treated by this Doctor:
Cancer Genetics, Colorectal Cancer, Hereditary/Familial Cancers, Oesophagus Cancer, Stomach Cancer.

Clinical Appointments

  • Head Cancer Genetics Service National Cancer Centre SingaporeNational Cancer Centre Singapore
  • Deputy Head SingHealth Duke-NUS Genomic Medicine Centre
  • Service Chief, Cancer Genetics SingHealth Duke-NUS Genomic Medicine Centre
  • Senior Consultant Division of Medical Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore
  • Senior Consultant Paediatric Brain and Solid Tumour Programme KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Visiting Consultant KK Breast Centre KK Women's and Children's HospitalKK Women's and Children's Hospital

Academic Appointments

  • Associate Professor, Lee Kong Chian School of Medicine, Nanyang Technological University


Dr Joanne Ngeow, MBBS, MRCP, MPH is Senior Consultant, Division of Medical Oncology at the National Cancer Centre Singapore and Associate Professor, Lee Kong Chian School of Medicine, Nanyang Technological University. Dr Ngeow currently heads the Cancer Genetics Service at the National Cancer Centre Singapore with an academic interest in hereditary cancer syndromes and translational clinical cancer genetics. She was awarded consecutive fellowships by the National Medical Research Council and the Ambrose Monell Foundation to complete formal clinical and bench training in Cancer Genomic Medicine at the Genomic Medicine Institute, Cleveland Clinic, Ohio. Dr Ngeow’s research focuses on understanding how a gene-environmental interaction predisposes to cancer initiation and progression. Her team seeks to identify, characterize and understand genes which cause susceptibility to traditional and complex heritable cancer syndromes, to determine their role in sporadic carcinogenesis. The Cancer Genetics Service led by Dr Ngeow is the go-to for clinical cancer genetics in Singapore and the region. Dr Ngeow is funded by the National Medical Research Council, Terry Fox Foundation and Lee Foundation. Her work is published in over 70 peer-reviewed top scientific journals and she is the recipient of consecutive scientific awards from the American Society of Clinical Oncology and Endocrine Society in recognition of her contributions to the field of cancer genomic medicine.


  • MPH, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA 
  • FAMS, Fellow, Academy of Medicine Singapore (Medical Oncology)
  • MMed, National University of Singapore 
  • MRCP, Royal College of Physicians (UK) 
  • MBBS (Hons), University of Melbourne

Professional Appointments and Committee Memberships

  • Associate Professor, Lee Kong Chian School of Medicine, Nanyang Technological University
  • Life member, Asia Pacific Society of Human Genetics
  • Fellow, Academy of Medicine, Singapore (Clinician Scientist)
  • Member, European Society of Human Genetics 
  • Member, F1000 
  • Member, The Endocrine Society Member, American Association for Cancer Research 
  • Member, American Society of Human Genetics 
  • Fellow, Academy of Medicine, Singapore (Medical Oncology)


  • SingHealth Publish! Award (Outstanding), 2016 
  • Endocrine Society Early Investigator Award, ENDO, 2016 
  • National Medical Research Council Transition Award, 2014 
  • Excellence in Education Award, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, OH, USA, 2013 
  • ASCO Merit Award, American Society of Clinical Oncology Annual Meeting, Chicago, IL, USA, 2013 
  • ASCO Merit Award, American Society of Clinical Oncology Annual Meeting, Chicago, IL, USA, 2012

Research Interests

  • Human Cancer Genetics and Genomic Medicine 
  • Molecular Epidemiology of Cancer 
  • Genetics of Neuroendocrine and Endocrine Neoplasias
  • Cowden Syndrome and PTEN-Related Cancers Inherited Hamartoma-Neoplasia Syndromes
  • Integrative Genomics of Host Genome-Meteganome Interactions 
  • Health Services Research on Clinical Cancer Genetics and Genetic Counselling / Cost Effectiveness


  • Li ST, Yuen J, Zhou K, Binte Ishak ND, Chen Y, Met-Domestici M, Chan SH, Tan YP, Allen JC Jr, Lim ST, Soo KC, Ngeow J. Impact of subsidies on cancer genetic testing uptake in Singapore. J Med Genet. 2017 Apr;54(4):254-259. 
  • Chan SH, Lim WK, Michalski ST, Lim JQ, Ishak ND, Met-Domestici M, Young CN, Vikstrom K, Esplin ED, Fulbright J, Ang MK, Ngeow J et al. Germline hemizygous deletion of CDKN2A–CDKN2B locus in a patient presenting with Li–Fraumeni syndrome. npj Genomic Medicine. 2016 Jun 1;1:16015. 
  • Ho SSW, Tan N, Zhang W, Khatoo M, Tripathi S, Cheung F, Lim WK, Tan PH, Ngeow J, Gasser S. The DNA structure-specific endonuclease MUS81 mediates STING-dependent host rejection of prostate cancer cells. Immunity 2016 May 17;44(5):1177-89 [Featured on UroToday] 
  • Wong A, Kuick CH, Wong WL, Tham JM, Mansor S, Loh E, Jain S, Vikas NN, Tan SH, Chan SH, Li ST, Chew SH, Hong W, Ngeow J. Mutation spectrum of POLE and POLD1 mutations in South East Asian women presenting with Grade 3 endometrioid endometrial carcinomas. Gynecol Oncol. 2016 Apr;141(1):113-20 
  • Tan R, Met-Domestici M, Zhou K, Guzman A, Lim ST, Soo KC, Feeley TW, Ngeow J. Using Quality Improvement Methods and Time-Driven Activity Based Costing to Improve Value-Based Cancer Care Delivery at a Cancer Genetics Clinic. J Oncol Pract 2016 Mar;12(3):e320-31 
  • Tan G, Zhou K, Tan CH, Matchar DB , Farid M, Quek R, Ngeow J. Cost-Effectiveness of Universal Hepatitis B Virus (HBV) Screening in Patients Beginning Chemotherapy for Sarcoma and Gastrointestinal Stromal Tumors (GIST). J Global Oncol February 17, 2016; DOI:10.1200/JGO.2015.001669 
  • Koo SX, Chan SH, Ngeow J. Genetic predisposition resulting in sinusoidal obstruction syndrome in a patient with resected sigmoid cancer on adjuvant oxaliplatin. BMJ Case Rep. BMJ Case Rep. 2016 Jan 4;2016. 
  • Chng KR, Chan SH, Ng A, Li CH, Jusakul A, Bertrand D, Wilm A, Choo SP, Tan D, Lim KH, Soetinko R, Ong CK, Duda D, Dima S, Popescu I, Wongkham C, Feng Z, Yeoh KG, Teh BT, Yongvanit P, Wongkham S, Bhudhisawasdi V, Khuntikeo N, Tan P, Pairojkul C, Ngeow J* Nagarajan N*. Tissue Microbiome Profiling Identifies An Enrichment of Specific Enteric Bacteria In Opisthorchis Viverrini Associated Cholangiocarcinoma. EBioMed Volume 8 , 195 - 202 [Feature cover article]. *Joint Senior Author 
  • Wong M, Chu YH, Tan AHL, Bessho H, Ngeow J, Tang T, Tan MH. Clinical and molecular characteristics of East Asian patients with von Hippel-Lindau syndrome. Chin J Cancer. 2016 Aug 15;35(1):79. 
  • Chen HH, Händel N, Ngeow J, Muller J, Hühn M, Yang HT, Heindl M, Berbers RM, Hegazy AN, Kionke J, Yehia L, Sack U, Bläser F, Rensing-Ehl A, Reifenberger J, Keith J, Travis S, Merkenschlager A, Kiess W, Wittekind C, Walker L, Ehl S, Aretz S, Dustin ML, Eng C, Powrie F, Uhlig HH. Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells. J Allergy Clin Immunol. 2016 Jun 18

Research Trials

  • Molecular Mechanism of Cancer Predisposition: Ongoing 
  • Longitudinal Follow Up study of BRCA1/2 Carriers: Ongoing 
  • Understanding the patient experience with genetic testing: Ongoing