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Clin Assoc Prof Tan Ju Le

Clin Assoc Prof Tan Ju Le


Senior Consultant

National Heart Centre Singapore

Specialty: Cardiology

Clinical Interest: Adult Congenital Heart Disease, Echocardiography, Pulmonary Hypertension, Cardiac Disease in Pregnancy

Clinical Appointments

  • Senior Consultant Department of Cardiology National Heart Centre SingaporeNational Heart Centre Singapore
  • Director of Adult Congenital Heart Disease National Heart Centre SingaporeNational Heart Centre Singapore
  • Visiting Consultant Cardiology Service KK Women's and Children's HospitalKK Women's and Children's Hospital


Clinical Associate Professor Tan Ju Le is a Senior Consultant from the Department of Cardiology, and Director of the at Adult Congenital Heart Disease (ACHD) programme at the National Heart Centre Singapore (NHCS). She specialises in Adult Congenital Heart Disease (ACHD), Echocardiography and Pulmonary Hypertension.

Clin Assoc Prof Tan has gone for further training in Adult Congenital Heart Disease at the Royal Brompton Hospital in London from 2003 to 2005. Main interest is in the care of adults with congenital heart disease, management of cardiac disease in pregnancy and pulmonary hypertension. She runs the monthly joint Cardiac Obstetric Clinic with obstetricians from the Singapore General Hospital.

She is also a Clinical Associate Professor at the Duke-NUS Medical School and Senior Lecturer at the Faculty of Medicine at the National University of Singapore.

Clin Assoc Prof Tan has written for numerous publications and is a co-author of several book chapters. She is also a reviewer of the International Journal of Cardiology and local journals like Annals, Academy of Medicine, Singapore. She is involved in clinical trials and research in hyperlipidemia and pulmonary hypertension.


  • FESC (Fellow of the European Society of Cardiology), 2011
  • FACC (Fellow of the American College of Cardiology), 2011
  • FAMS (Fellow of the Academy of Medicine, Singapore), 2003
  • Certificate of Specialist Accreditation, Singapore, 2002
  • MRCP (Member of the Royal College of Physicians, UK), 1996
  • MBBS (Newcastle University, United Kingdom), 1993

Professional Appointments and Committee Memberships

  • Senior Consultant, Department of Cardiology, National Heart Centre Singapore
  • Director, Adult Congenital Heart Diseases, National Heart Centre Singapore
  • Visiting Consultant, Singapore General Hospital, 2009 – Present
  • Visiting Consultant, Cardiology Service, KK Women's and Children's Hospital, 2005 – Present
  • Clinical Associate Professor, Duke-NUS Medical School
  • Adjunct Assistant Professor, Duke-NUS Medical School, 2015 – 2018
  • Senior Lecturer, National University of Singapore (NUS) Medical School, 2012 – Present
  • Senior Clinical Lecturer, NUS Yong Loo Lin School of Medicine
  • Fellow of the European Society of Cardiology, 2011 – Present
  • Fellow of the American College of Cardiology, 2011 – Present
  • Completed 18 months fellowship in Adult Congenital Heart Disease at the Royal Brompton Hospital, London, UK in 2005
  • Fellow of the Academy of Medicine Singapore, 2003 – Present


  • Singhealth Excellence Awards 2021 – Distinguished Team Award (Formation of the Chronic Thromboembolic Pulmonary Hypertension Team)
  • ​Singapore Health Quality Service SuperStar (Clinical) Award, 2015
  • Singhealth Residency Outstanding Faculty Award, 2014
  • Singapore Health Service Quality Award – Platinum, 2013
  • Singapore Health Quality Service Award – Gold, 2012
  • Singapore Health Service Award – Silver, 2011

Research Interests

  • Tetralogy of Fallot
  • Echo imaging in congenital heart Disease
  • Pulmonary hypertension


  • Pseudocoarctation of the aorta. Phong Teck Lee, Ju Le Tan. J Clin Med Img Case Rep. 2022; 2(1): 1071.
  • Sacubitril/valsartan for heart failure in patients with complex adult congenital heart disease – Experience from a tertiary centre in Singapore. Yan Limin, Julian Kendrik Loh, Tan Ju Le. International Journal of Cardiology Congenital Heart Disease; Vol 6, Dec 2021.
  • Impact of age, sex and ethnicity on intra-cardiac flow components and left ventricular kinetic energy derived from 4D flow CMR.  Xiaodan Zhao, Ru-San Tan, Pankaj Garg, Ping Chai, Shuang Leng, Jennifer Bryant, Lynette LS Teo, Ching Ching Ong, Rob J van der Geest, John C Allen, James W Yip, Ju Le Tan, Sven Plein, Jos JW Westenberg, Liang Zhong. International Journal of Cardiology. IJCA-29564; No of Pages 8.
  • Age-and Sex-Specific Changes in CMR Feature Tracking-Based Right Atrial and Ventricular Functional Parameters in Healthy Asians.  Shuang Leng, Jiajun Guo, Ru-San Tan, Ping Chai, Lynette Teo, Marielle Fortier, Chao Gong, Xiaodan Zhao, Ching Ching Ong, John C Allen, Wen Ruan, Angela S Koh, Teng Hong Tan, James W Yip, Ju Le Tan, Yucheng Chen, Liang Zhong.  Frontiers in Cardiovascular Medicine. June 2021 l Volume 8 l Article 664431.
  • Cardiovascular Magnetic resonance-assessed fast global longitudinal strain parameters add diagnostic and prognostic insights in right ventricular volume and pressure loading disease conditions.  Shuang Leng, Ru-San Tan, Jiajun Guo, Ping Chai, Gangcheng Zhang, Lynette Teo, Wen Ruan, Tee Joo Yeo, Xiaodan Zhao, John C. Allen, Ju Le Tan, James W. Yip, Yucheng Chen and Liang Zhong. Journal of Cardiovascular Magnetic Resonance. Leng et al. J Cardiovasc Magn Reson (2021) 23:38.
  • Patient-specific computational analysis of hemodynamics and wall mechanics and their interactions in pulmonary arterial hypertension. Byron A Zambrano, Nathan Mclean, Xiaodan Zhao, Ju-Le Tan, Liang Zhong, C. Alberto Figueroa, Lik Chuan Lee, Seungik Baek.  Frontiers in Bioengineering and Biotechnology, section Biomechanics. January 2021| Volume | Article 611149.
  • Three-dimensional biventricular strains in pulmonary arterial hypertension patients using hyperelastic warping. Hua Zou, Shuang Leng, Ce Xi, Xiaodan Zhao, Angela S Koh, Fei Gao, Ju Le Tan, Ru-San Tan, John C Allen, Lik Chuan Lee, Martin Genet, Liang Zhong.  Computer Methods and Programs in Biomedicine 189 (2020) 105345 Elsevier.
  • Mortality and hospitalization outcomes of interstitial lung disease and pulmonary hypertension in the Singapore systemic sclerosis cohort Maria Noviania , Seyed Ehsan Saffari, Ju Le Tan, James Wei Luen Yip , Gim Gee Teng, Weng Giap Law, Grace Yin Lai Chan, Amelia Santosa, Anita Yee Nah Lim, Cassandra Hong, Sue-Ann Ng, Edgar Lik Wui Tay, Wen Ruan, Jonathan Yap, Andrea Hsiu L. Seminars in Arthritis and Rheumatism 50 (2020) 473479
  • TGA With Interarterial Course and Athletes Heart A Diagnostic Dilemma Answered by Stress CMR Felix Maverick R. Uy, Phong Teck Lee, Jie Sheng Foo, Thu-Thao Le, Ju Le Tan, Calvin Woon-Loong Chin. JACC: CASE REPORTS, VOL. 2, NO. 5, 2020
  • Clinical Updates on the Diagnosis and Management of Chronic Thromboembolic Pulmonary Hypertension. Ruan W1, Yap JJ, Quah KK, Cheah FK, Phua GC, Sewa DW, Ismail AB, Chia AX, Jenkins D, Tan JL, Chao VT, Lim ST. Annals of the Academy of Medicine, Singapore, 01 May 2020, 49(5):320-330. PMID: 32582909
  • Pregnancy in Cardiac disease–An audit on outcomes in the Joint Cardiac Pregnancy Clinic, Singapore General Hospital. LK Tan, YH Tan, J Le Tan, S Thain, EL Tan - Pregnancy Hypertension, 2018 – Elsevier.
  • Increased incidence of infective endocrditis in patients with ventricular septal defect. PT Lee, FM Uy, JS Foo, JL Tan - Congenital heart disease, Volume 13, Issue 6, 2018 - Wiley Online Library
  • Is subdural haemorrhage after pulmonary endarterectomy underrecognized? Jonathan Yap, Wen Ruan, Alicia Chia, Kenny Loh, Foong Koon Cheah, Ai Leen Ang, Ghee Chee Phua, Duu wen Sewa, David Jenkins, Ju Le Tan, Victor Chao, Soo Teik Lim. The Journal of Thoracic and Cardiovascular Surgery 2018: 1-4.
  • Impaired Cardiovascular Magnetic Resonance–Derived Rapid Semiautomated Right Atrial Longitudinal Strain Is Associated with Decompensated Hemodynamics in Pulmonary Arterial Hypertension. Shuang Leng, Yang Dong , Yang Wu , Xiaodan Zhao , Wen Ruan , Gangcheng Zhang, John C. Allen , Angela S. Koh , Ru-San Tan , James W. Yip, Ju Le Tan, Yucheng Chen , Liang Zhong.  Circulation: Cardiovascular Imaging 2019, May Vol 12, Issue 5
  • Comparative analysis of right heart chamber remodelling after surgical and device secundum atrial septal defect closure in adults. Jie Sheng Foo, Maksym Lazu, Si Ying Pang, Phong Teck Lee, Ju Le Tan. Journal of Interventional Cardiology. 2018;31:672-678.
  • Efficient estimation of personalized biventricular mechanical function employing gradient‐based optimization. Henrik Finsberg, Ce Xi, Ju Le Tan, Liang Zhong, Martin Genet, Joakim Sundnes, Lik Chuan Lee Samuel T. Wall. International Journal for Numerical Methods in Biomedical Engineering.Volume 34, Issue 7, July 2018
  • Image-based computational assessment of vascular wall mechanics and hemodynamics in pulmonary arterial hypertension patients. Zambrano BA, McLean NA, Zhao X, Tan JL, Zhong L, Figueroa CA, Lee LC, Baek S. Journal Of Biomechanics [J Biomech] 2018 Feb 08; Vol. 68, pp. 84-92. Date of Electronic Publication: 2017 Dec 27.
  • Percutaneous Decommssioning of Left Ventricular Assist Device. Jia-Lin Soon, Ju-Le Tan, Choon-Pin Lim, Teing-Ee Tan, Swee-Yaw Tan, Ka-Lee Kerk, Kheng-Leng David Sim, Cumaraswamy Sivathasan. Heart, Lung and Circulation (2018) 27, 853-855
  • Management of cardiomyopathy in pregnancy in a tertiary hospital: Case series of 7 cases of cardiomyopathy managed in Singapore General Hospital. YH Tan, S Thain, L kok Tan, HK Tan, EL Tan, F Chen, J Le Tan. Pregnancy Hypertension, Volume 13, October2018 – Elsevier
  • Computational Platform Based on Deep Learning for Segmenting Ventricular Endocardium in Long-axis Cardiac MR Imaging. L Shuang, X Yang, AS Koh, D Sim, J Le Tan, R San Tan… - Published in: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Three-Dimensional Tricuspid Annular Motion Analysis from Cardiac Magnetic Resonance Feature-Tracking. Leng S, Jiang M, Zhao XD, Allen JC, Kassab GS, Ouyang RZ, Tan JL, He B, Tan RS, Zhong L. Ann BiomedEng.2016 Dec;44(12):3522-3538. [Epub 2016 Jul 19].
  • Multiple pregnancy in a primigravida with uncorrected Pentalogy of Fallot. Partana P, Tan JK, Tan JL, Tan LK. BMJ Case Rep.2017 Jan 18;2017. Pii:bcr2016216809. doi:10.1136/bcr-2016-216809.
  • A case of successfully managed pregnancy in a patient with complex cyanotic congenital heart disease. JY Liu, WK Tan, EL Tan, JL Tan and LK Tan. Obstetric Medicine Journal. 0(0) 1-5 2016
  • Aortic Dilatation at Different Levels of the Ascending Aorta in Patients with Bicuspid Aortic Valve. Fei Qiong Huang, Kenneth WQ Guo, Liang Zhong, Fei Gao, Ju Le Tan. Annals, Academy of Medicine, Singapore. Vol 45. No 6 June 2016
  • Molecular pathogenesis of Marfan syndrome. Chrishan J.A. Ramachandra, Ashish Mehta, Kenneth Wei Qiang Guo, Philip Wong, Ju Le Tan, Winston Shim. International Journal of Cardiology, May 6, 2015 Volume 187, Pages 585-591.
  • Pattern of Aortic Dilatation in Different Biscupid Aortic Valve Phenotypes and its Association with Aortic Valvular Dysfunction and Elasticity. Fei Qiong Huang, MD, PhD, Ju Le Tan, MBBS, MRCP. Heart, Lung and Circulation (2014) 23, 32-28
  • Facing the Future – The growing burden of adult congenital heart disease. Kenneth Guo, Ju Le Tan, Koichiro Niwa, Ariane Marelli. Asian Hospital & Healthcare Management, Issue 27 2013.
  • An Unusual Cause of Severe Pulmonary Hypertension in a young woman. Wong SS, Ju Le Tan. Annals Acad Med Singapore. January 2013 Feb;42(2):91-2.
  • Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot. Liang Zhong, Like Gobeawan, Yi Su, Ju Le Tan, Dhanjoo Ghista, Terrance Chua, Ru San Tan and Ghassan Kassab. Am J Physiol Heart Circ Physiol . 2012 Mar 15;302(6):H1306-16. PMID:22210750[PubMed – indexed for MEDLINE].
  • 3-Years Post-Operative Outcome of a Recipient of Pulmonary Valve Homograft Originating from a Heart Transplant Patient in Singapore. Ling Heng Wee, Tan Ju Le, Lim Chong Hee and Lim Yeong Phang. J Clin Case Rep 2012, 2:17
  • Fragmented QRS complexes predict right ventricular dysfunction and outflow tract aneurysms in patients with repaired tetralogy of Fallot. Nesan Shanmugam, Jonathan Yap, Ru San Tan, Thu Thao Le, Fei Gao, Jia Xin Chan, Daniel Chong, Kah Leng Ho, Boon Yew Tan, Chi Keong Ching, Wee Siong Teo, Ju Le Tan, Reginald Liew. E-publish 2012, International Journal of Cardiology. Int J Cardiol. 2013 Aug 20;167(4):1366-72. PMID:22521381[PubMed – in process]
  • Emergency admissions in Asians with adult congenital heart disease. Angela S. Koh, Betty T. Yap, Ju Le Tan.  Elsevier International Journal of Cardiology 151 (2011) 54-57
  • Ventricular septal rupture following acute myocardial infarction. Angela S. KOH, Yee Jim LOH, Yeong Phang LIM, Ju Le TAN. Acta Cardiologica 2011 Apr;66(2): 225-230.  Int J Cardiol. 2011 Aug 18;151(1):54-7. Doi: 10.1016/j.ijcard.2010.04.088. Epub 2010 Jun 8. PMID:20570378[PubMed – indexed for MEDLINE].
  • Large pulmonary artery aneurysm associated with Marfan Syndrome. Peter Ting, Bodh I Jugdutt, Ju Le Tan. Int J Angiol. 2010 Spring; 19(1):e48-e50. PMID:22477577[PubMed].
  • Association of Patent Ductus Arteriosus with Tetralogy of Fallot. Koh AS, Tan JL. Proceedings of Singapore Healthcare, a publication of Singhealth Academy.  Vol 19 No 3: 2010.
  • The Impact of Transcatheter Atrial Septal Defect Closure in the Older Population. Arif Anis Khan, MD, Ju-Le Tan, MD, W. Li, PhD, Kostas Dimopoulos, MD, PhD, Mark S. Spence, MD, Pak Chow, MD, Michael J. Mullen, MD. JACC Intv, 2010; 3:276-281, dol:10.1016/j.jcin.2009.12.011. 2010 by the American College of Cardiology Foundation.
  • An apolipoprotein B Synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial. Frederick J Raal, Raul D Santos, Dirk J Blom, A David Marais, Min-Ji Charng, William C Cromwell, Robin H Lachmann, Daniel Gaudet, Ju L Tan, Scott Chasan-Taber, Diane L Tribble, JoAnn D Flaim, Stanley T Crooke.  Mipomersen. The Lancet March 14, 2010. DOI:10.1016/S0140-6736(10)60284-X
  • Pulmonary hypertension: an unusual presentation of an iatrogenic hepatic arterioportal fistula and its successful resolution post-embolotherapy. Chua DY, Pavillion G, Tay KH, Tan JL, Chung AY. PubMed. Am Surg. 2009 Jun;75(6):511-4.
  • Hepatotocellular Carcinoma-A Rare Complication Post Fontan Operation. See H.Ewe, Ju L.Tan. Congenital Heart Disease. 2009;4:103-106.
  • Wakeboarding-related water impact trauma as a cause of fatal cardiac rupture. Jang Wen Su, Chong Hee Lim, Ju Le Tan, Yeow Leng Chua, Paul Peng Sun Chui. The Journal of Thoracic and Cardiovascular Surgery August 2007;134:506-7.
  • An Adult with Truncus Arteriosus and Unilateral Pulmonary Hypertension. Tang Hak Chiaw, Tan Ru San, Tan Ju Le. Congenital Heart Disease. 2007;2:433-437.
  • Late Complications Following Tetralogy of Fallot Repair: The Need for Long-term Follow-Up. Kay Woon Ho, Ru San Tan, Keng Yean Wong, Teng Hong Tan, Sriram Shankar, Ju Le Tan. Annals Academy of Medicine.  November 2007, Vol. 36 No. 11
  • The right ventricular response to high afterload: Comparison between atrial switch procedure, congenitally corrected transposition of the great arteries, and idiopathic pulmonary arterial hypertension. Tan JL, Prati D, Gatzoulis MA, Gibson D, Henein MY, Li W. Am Heart J 2007; 153:681–8
  • Large Unrepaired Aortopulmonary Window – Survival into the Seventh Decade. Koh ASM, Tan JL. Echocardiography 2006 Vol. 24(1):1–3.
  • Adult Congenital Heart Disease: Moving Beyond the Paediatric Horizon. Tan JL.  SGH Proceedings 2006, Vol. 15 no. 3, pg 121–126
  • Aortic root disease in tetralogy of Fallot. Tan JL, Gatzoulis MA, Ho SY.  Current Opin Cardiology, 2006, Nov;21(6): 569-72
  • Images in Cardiology: Persistent left sided superior vena cava. KL Ho, JL Tan. Heart 2006; 92:1046
  • LV abscess – Unusual presentation of Endocarditis. Tan JL, Broberg C, Mullen M, Gatzoulis MA, Li W. EAE Clinical Case Reports, 1 May 2006.
  • Doppler echo-cardiographic profile and indices in the evaluation of aortic coarctation in patients before and after stenting. Tan JL, Babu-Narayan S, Henein MY, Mullen M, Li W. JACC. 2005 Sep 20; 46(6): 1045-53
  • Intrinsic Histological Abnormalities of the Aortic Root and Ascending Aorta in Tetralogy of Fallot : Evidence of causative mechanism for aortic dilatation and Aortopathy. Tan JL, Davlouros PA, Mc Carthy KP, Gatzoulis MA, Ho SY. Circulation.  August 2005, Vol 112 no. 7, pg 961-968
  • Emergency stent graft deployment for acute aortic rupture following primary stenting for aortic coarctation. Tan JL, Mullen M. Catheter Cardiovasc Interven. June 2005, Vol 65:306-309
  • Images in Cardiology: Atrial Flutter with 1:1 Conduction. JL Tan, WS Teo. Heart 2002; 88:414.
  • Immediate and Mid-Term Safety and Efficacy of Single Lead VDD Pacemaker for Patients with Atrioventricular Block and Normal Sinus Node Function – A Single Centre Experience. JL Tan, LF Hsu, RML Kam, WS Teo. Ann Acad Med Singapore January 2003, Vol.32 No.1.

(Books & book chapters)

  • Aortopathy by Koichiro Niwa (Editor), Harald Kaemmerer (Editor). Published  17/2/2017 by Springer. Chapter 6: Imaging CT, Echo and MRI. Pages 75-111. Kenneth Guo, Narayan Lath, Ju Le Tan.
  • "Shunts” - Atrial Septal Defects/Abnormal Pulmonary Venous Return “Right Heart Enlargement of Uncertain Cause (Sinus Venosus Atrial Septal Defect). Ju-Le Tan, Wei Li, Elisabeth Bedard. Cases in Adult Congenital Heart Disease. Pg 1-6, 2009.
  • Rationale for Septal Defect Closure in the Elderly. Ju-Le Tan, Wei Li, Michael J. Mullen. Cases in Adult Congenital Heart Disease Pg 7-12, 2009.
  • Myocardial ischaemia in congenital heart disease - the role of non-invasive imaging  Anagnostopoulos C, Bax JJ, Nihoyiannopoulos P, van der Wall E. Tan JL, Loong C, Kilner P, Li W, Gatzoulis MA. Noninvasive Imaging of Myocardial Ischaemia. Chapter 15, pg 287-306, Springer-Verlag London 2006.

Research Trials

  • United Therapeutics ROR-PH-301: Ranilipeg PH study (2020)
  • Integrated computational modelling of right heart mechanics and blood flow dynamics in congenital heart disease (12 Aug 2016 for a duration of 3 years).
  • United Therapies PH Study (2014)
  • Sildenafil Trial_PAH patients (PFIZER) 2014
  • DYSIS Trial (2013)
  • Tetralogy of Fallot (TOF) REMODELING Study (1 Mar 2010 for a duration of 3 years)
  • Diastolic Heart Failure Study (2010)
  • Tecos Study (2010)
  • LEPHT Trial (PAH)
  • GRIPHON 2 / GRIPHON (2009)
  • SERAPHIN Study (2008)
  • PATENT Trial (2008)
  • PLATO Trial (2007)
  • INSPIRE ME Trial (2006)
  • EARLY Trial (2005/2006)
  • RELY Trial (2005/2006)
  • OVERTURE Study (2001)
  • PACT Study (2000)
  • CHARM Study (2000-2002)