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Asst Prof Valerie Yang Shiwen

Asst Prof Yang Valerie Yang Shiwen

MB BChir (Cantab), PhD (Cantab), MRCP (UK), FAMS (Medical Oncology) (Clinician Scientists)

Consultant

National Cancer Centre Singapore

Specialty: Medical Oncology

Sub-specialties: Sarcoma, Lymphoma, Skin & Melanoma, Melanoma, Sarcoma/Skin

Conditions Treated by this Doctor:
Gastrointestinal Stromal Tumour (GIST), Lymphoma, Melanoma, Sarcoma, Skin Cancer.

Clinical Appointments

  • Consultant Division of Medical Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore

Academic Appointments

  • Oncology Academic Clinical Programme

Profile

Asst Professor Valerie Yang is a Consultant, Division of Medical Oncology at the National Cancer Centre Singapore. She is jointly appointed as a Research Clinician & Group Leader at the Institute of Molecular and Cell Biology, A*STAR. Her interests include Sarcomas, Lymphomas and Melanomas.

She received the National Science Scholarship from the Agency for Science, Technology and Re-search (A*STAR) to read Medicine and a PhD. She graduated from the Royal Free and University College Medical School with Distinctions in Preclinical Medicine and First Class Honours for a Bach-elor of Science (BSc) in Molecular Medicine. She was conferred the Cluff Memorial Prize and the Goldberg-Schachmann and Freda Becker Memorial Award, and joined the A*STAR Chairman’s Honours List. Dr. Yang then read Clinical Medicine at the University of Cambridge, where she was accepted into the prestigious MB/PhD Programme. Her PhD in Oncology was supervised by Dr. Mi-chael Gonzalez and Professor Ronald Laskey, where she studied DNA replication, cell cycle regula-tion and embryonic stem cell pluripotency.

Upon returning to Singapore, Dr. Yang underwent Internal Medicine residency training and was ac-cepted to the Membership of the Royal College of Physicians (MRCP), UK, before receiving special-ty training in Medical Oncology at the NCCS. She was also conferred the Nurturing Clinician Scien-tists Scheme Award (NCSS) by SingHealth for Sarcoma research while concurrently undergoing spe-cialty training. She is now accredited as a Specialist in Medical Oncology and a Fellow of the Acad-emy of Medicine of Singapore. As an Associate Consultant, she also won the National Medical Re-search Council (NMRC) Transition Award 2021 for her work in Sarcomas.

Education

  • Fellow, College of Clinician Scientists, Academy of Medicine, Singapore, 2021
  • Fellow of the Academy of Medicine, Singapore (Medical Oncology), 2019
  • Specialist Accreditation in Medical Oncology, Ministry of Health Singapore, 2019
  • MRCP, Royal College of Physicians (UK), 2014
  • PhD, University of Cambridge, 2010
  • MBBChir, University of Cambridge, 2010
  • Bachelor of Science with First Class Honours, University College London, 2003

Professional Appointments and Committee Memberships

  • Mentor, SingHealth Internal Medicine Residency Program, 2021 – Present
  • Internal Medicine Panel, Department of Internal Medicine, Singapore General Hospital, 2021 - Present 
  • Consultant, Division of Medical Oncology, National Cancer Centre Singapore, 2021 - Present
  • Assistant Professor, Oncology Academic Clinical Program, Duke-NUS Medical School, 2021 - Present
  • Clinical Physician Faculty Member, SingHealth Medical Oncology Residency Programme, 2021 – Present
  • Associate Consultant, Division of Medical Oncology, National Cancer Centre Singapore, 2019 – 2021
  • Research Clinician & Group Leader, Institute of Molecular and Cell Biology, A*STAR, 2019 - Present
  • Adjunct Instructor, Oncology Academic Clinical Program, Duke-NUS Medical School, 2019 – 2021
  • American Association for Cancer Research, 2015 - Present
  • Singapore Society of Oncology (SSO), 2014 – Present
  • American Society of Clinical Oncology (ASCO), 2014 – Present
  • European Society of Medical Oncology (ESMO), 2014 – Present

Awards

  • Singhealth Long Service Award, 2022
  • National Medical Research Council (NMRC) Transition Award, 2021
  • Nurturing Clinician Scientists Scheme Award, SingHealth, 2016
  • Academic Development Programme, National University Hospital, 2012
  • First Prize for Oral Presentation, Graduate Research Symposium, Cambridge University, 2009
  • Goldberg-Schachmann and Freda Becker Memorial award, University of London, 2003
  • Cluff Memorial Prize, Royal Free and University College Medical School, 2003
  • Distinction in Medical Sciences, Royal Free and University College Medical School, 2003
  • Chairman’s Honours List, A*STAR Graduate Academy, 2003
  • National Science Scholarship (MBBS-PhD), A*STAR, 2001

Research Interests

  • Drug screening
  • Biomarkers
  • Patient-derived models
  • Immunotherapy
  • Translational Artificial Intelligence and Machine Learning
  • Single-cell and digital spatial profiling technologies
  • Personalised medicine
  • Cancer epigenetics
  • Sarcoma, Lymphoma, Melanoma, Skin and rare cancers

Publications

  • Ko TK, Lee E, Ng CC, Yang VS et al., 'Circulating tumour DNA mutations in progressive gastrointestinal stromal tumours identify biomarkers of treatment resistance and uncover potential therapeutic strategies'. Front Oncol. 2022; 12:840843. Published 2022 Feb 22. doi: 10.3389/fonc.2022.840843
  • Yang VS et al., 2011, 'Geminin escapes degradation in G1 of mouse pluripotent cells and mediates the expression of Oct4, Sox2, and Nanog', Current Biology 21 (8), 692-699 
  • Yang VS et al., 2012, 'Distinct activities of the anaphase-promoting complex/cyclosome (APC/C) in mouse embryonic cells', Cell Cycle 11 (5), 846-855 
  • Yang VS et al., 2020, 'Clinicopathologic Features and Whole Genome Sequencing of a Primary Osteosarcoma of the Uterus', Journal of Immunotherapy and Precision Oncology 3 (2), 90-95 
  • Chiang J, Yang VS et al., 2020, 'Minimizing transmission of COVID-19 while delivering optimal cancer care in a National Cancer Centre', Journal of Cancer Policy 25, 100241
  • Yap DRY, Tan GF, Chang EWY, Yang VS et al., 2020, 'Clinical Features of Plasmablastic Lymphoma: Case Series From an Asian Tertiary Cancer Center and Literature Review', Journal of Haematology 9 (3), 71 
  • Tan L, Hong J, Goh WL, Chang EWY; Yang VS et al., 2020 'Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort' Sci Rep 10, 16367 (2020) 
  • Tham CSW, Tan YH, Chew KMYC, Khoo CY, Lee L, Lim ST, Yang VS. 2021, 'An Unusual Presentation of Lymphoma', Current Problems in Cancer 4, 100080
  • Lim LHS, Luo B, Chan SPY, Tang PY, Chen MW, Wong RX, Toh TB, Chow EK, Rashid MFBH, Yang VS. 2021, 'Rare Intracranial Relapse of a Resected Gastrointestinal Stromal Tumour: A Case Report', Clin Oncol Case Rep 4:8 Sep 2021. 
  • Ng DZ, Lee CY, Lam WW, Tong AK, Tan SH, Khoo LP, Tan YH, Chiang JB, Chang EW, Chan JY, Poon EY, Somasundaram N, Rashid MFH, Tao M, Lim ST, Yang VS. 2021, 'Prognostication of Diffuse Large B-cell Lymphoma patients with Deauville Score of 3 or 4 at end-of-treatment PET evaluation: A comparison of the Deauville 5-point scale and the ΔSUVmax method', Leukaemia and Lymphoma. Oct 2021 
  • Lo YT, Ang YLS, Yang VS et al., 2020, 'Motor deficits at presentation and predictors of overall survival in central nervous system lymphomas', Journal of Neuro-Oncology 2021 Jan 4.
  • Tan CJ, Kumar R, Koomanan N, Loo WS, Farid M, Tao M, Somasundaram N, Poon E, Chan JY, Yang VS et al., 2021, 'Clinical and economic evaluation of a surveillance protocol to manage hepatitis B virus (HBV) reactivation among lymphoma patients with resolved HBV infection receiving rituximab', Pharmacotherapy, 41: 332-341.
  • Yang X, Khoo LP, Chang EWY, Yang VS et al., 2021, 'Treatment patterns and outcomes of older patients with mantle cell lymphoma in an Asian population', BMC Cancer 21, 566 (2021).
  • Tay T, Somasundaram N, Lim C; Khoo LP, Goh A, Lee YS, Liu X, Tao M, Quek R, Mohamad F,  Poon E, Chan JYS, Chang EWY, Yang VS et al., 'Treatment outcomes of T and natural-killer/T-cell lymphoma with Ifosfamide, Carboplatin, Etoposide (ICE) chemotherapy'. Cancer Reports (In Press). 
  • Chiang J, Yang VS et al., 'Oncology workload in a tertiary hospital during the COVID-19 pandemic'. Proceedings of Singapore Healthcare. Oct 2021 
  • Sng ECY, Han S, Yang VS et al., 'Oncology patients with pulmonary infiltrates in  the   COVID-19  era:  a  case  series' Singapore Medical Journal 2021, 1–11.

Research Trials