Biologics and biosimilar - side effects, precautions and contraindications

Biologics & Biosimilars - Side Effects, Precautions, and Contraindications

Increased risk of infection such as upper respiratory tract infection (URTI), urinary tract infection (UTI) and skin infections. If you develop a fever, sore throat, pain on urination or feel generally unwell, see a doctor immediately.
Reactivation of certain infectious diseases such as Hepatitis B or Tuberculosis (TB). Your doctor will order tests to assess your risk and decide on treatment before starting a biologic or biosimilar. In addition, your doctor will ensure your vaccination status is updated to further reduce your risk of getting an infection.
Increased risk of certain cancer such as lymphoma (cancer of the blood cell), skin and lung. Your doctor will examine you regularly and order tests when necessary for monitoring.
Allergic reactions such as shortness of breath, chills, itchiness, redness or swelling around the eyes/lips/skin may develop. Certain medications may be given before the injection to minimise this risk. If you experience any of such symptoms, stop the medicine and see your healthcare professional so it can be treated immediately.

Side effects for biologics and biosimilars

Common > 10%

Infection such as cold, upper respiratory infection, sinusitis

Mild injection site reactions such as redness and pain

Uncommon 1-3%

Severe infection require hospitalisation

Severe infusion reactions

Rare < 1 in 1000

Tuberculosis (TB)

Shingles

Hepatitis B

Cancer of the blood, skin or lung

Immune diseases such as lupus-like syndrome