Skip Ribbon Commands
Skip to main content


Drug Class: Commonly Known As: Category:
Endothelin Receptor Antagonist Tracleer

Bosentan - Side Effects, Precautions, and Contraindications

What side effects can Bosentan cause?

  • Bosentan may cause changes in liver enzymes. Although these are not usually significant, you will need frequent blood tests (monthly) to monitor your liver function. Inform your Cardiologist, Nurse and/or Pharmacist if you have signs of liver problems like dark urine, increased tiredness, loss of appetite, light- coloured stools, vomiting, yellow skin or eyes.
  • Bosentan may cause flushing, low blood pressure, fainting or headache. These effects are minimized by starting with a lower dose and may improve or go away with time. To reduce giddiness when changing position, rise slowly from a sitting or lying position.
  • Bosentan may cause anaemia (low haemoglobin level). Regular blood tests (full blood counts) will be scheduled to monitor this.
  • Bosentan may cause leg oedema (swelling). Inform your Cardiologist, Nurse or Pharmacist if you experience this.

Before taking Bosentan, what precautions must I follow?

Please inform your doctor if you are pregnant before starting this medicine.

What food or medicine must I avoid when I take Bosentan?

  • Patients taking Bosentan should not take Glibenclamide/Glyburide (a medication for diabetes) or Cyclosporine (a medication for suppression of the immune system) due to increased risk of side effects.
  • Bosentan may interact with certain antibiotics and antifungal medications taken by mouth. Please consult the Pulmonary Hypertension team if you are started on any of these.
  • Inform your Cardiologist, Nurse and/or Pharmacist if you are taking any other over-the- counter (OTC) medications, health/herbal supplements or traditional medications. The Pulmonary Hypertension Team will check to ensure that the combination of medications you are taking is safe.
  • Avoid grapefruit juice while on this medication.
  • Updated on
  • Article contributed by Department of Pharmacy National Heart Centre Singapore

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

    Find Your Medicines