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Ceritinib

Drug Class: Commonly Known As: Category:
Anaplastic Lymphoma Kinase (ALK) Tyrosine Kinase Inhibitor Zykadia® Cancer-related

Ceritinib - What is it for

Ceritinib is used to treat non-small cell lung cancer that has spread to other parts of the body. Your doctor will check for an alteration in your genes before starting you on this.

Ceritinib - Side Effects, Precautions, and Contraindications

What side effects can Ceritinib cause?

  • Nausea or vomiting, decreased appetite
    • Take small, frequent meals throughout the day
  • Diarrhea or constipation
    • To manage diarrhea:
      • Drink plenty of clear fluids to replace those lost (two litres everyday)
      • Avoid oily or spicy food and milk or dairy products
    • To manage constipation:
      • Drink more water or clear fluids (unless you have a limit on the amount that you can take each day)
      • Add more fibre to your diet by eating more fruits and vegetables
  • Stomach discomfort
  • Feeling tired and lack of energy
    • Do not drive or operate machinery when you feel tired
  • Increased blood sugar level

 If you experience any of the following symptoms, you should stop your medication and see your healthcare professional immediately.

  • Unusual weakness, tiredness or lightheadedness
  • Symptoms of a drug allergy including one or more of the following:
    • Swollen face/eyes/lips/tongue
    • Difficulty in breathing
    • Itchy skin rashes over your whole body

Before taking Ceritinib, what precautions must I follow?

  • Inform your healthcare professional if:
    • You are allergic to this medication or any of the other ingredients of this medication
    • You or your partner becomes pregnant or is planning for pregnancy. You should use effective birth control during and for at least:
      • Three months after stopping treatment (for men)
      • Six months after stopping treatment (for women)
    • You are breastfeeding
      • Do not breastfeed during and for at least two weeks after stopping treatment
    • You are taking any other medications, including supplements, traditional medications and herbal remedies
    • You have any other medical conditions (e.g. diabetes, heart problems)
  • Maintain personal hygiene and take precautions against infection.

What food or medicine must I avoid when I take Ceritinib?

Avoid taking grapefruit or grapefruit juice when you are taking this medication as it may interact with your medication and increase the risk of side-effects.

Ceritinib - Dosage and How to Use

How should Ceritinib be used?

  • Take Ceritinib once a day. Take the exact dose that your doctor tells you to.
  • Ceritinib should be taken after your food unless otherwise instructed by your doctor.
  • Do not break open or crush the capsules. Swallow the capsule whole.
    • Inform your doctor or pharmacist if you have difficulty swallowing

What should I do if I miss a dose?

​If you forget to take a dose, take it as soon as you remember. However, if there are less than 12 hours to your next dose, skip the missed dose and take your next dose at the usual time. Do not take two doses at the same time.

What should I do if I overdose?

Ceritinib - Handling

How should I handle Ceritinib safely?

Ceritinib - Storage

How should I store Ceritinib?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#Store at room temperature;#

How should I dispose of Ceritinib safely?

​Pack Ceritinib into a bag and bring it back to the pharmacy where you received the medication from.

Ceritinib - Additional Information

  • Tags: Ceritinib
  • Updated on Monday, August 31, 2020
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

    ​​​If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

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