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Clomiphene

Drug Class: Commonly Known As: Category:
Antiestrogen Adult

Clomiphene - What is it for

​Clomiphene is used as a fertility medication in some women who are unable to become pregnant. They work by changing the hormone balance of the body, causing ovulation to occur and thus prepares the body for conception.

Clomiphene - Side Effects, Precautions, and Contraindications

What side effects can Clomiphene cause?

  • Bloating, nausea and/or vomiting
    • Take the medication after food to reduce these side effects
  • Hot flushes
    • Wear loose fitting clothes or go to areas with air-conditioning
  • Dizziness/light-headedness and tiredness
    • Avoid activities that require mental alertness and avoid using heavy machineries.
  • Headache, muscle aches or joint pains
    • You may take paracetamol to relieve such symptoms.

Rare but serious side effects include blood clot formation. However, blood clot formation is rare and the doctor would have evaluated and weighed its benefits over risks before making the recommendation.

The symptoms of blood clot include one or more of the following

  • Any unusual sudden cough, breathlessness or difficulty in breathing
  • Severe pain in the chest which may reach the left arm
  • Severe pain in legs or swelling in either of your legs
  • Weakness or numbness in any part of your body
  • Change in your speech, including slurring of words
  • Change in your senses of hearing, smell or taste
  • Vision changes such as loss of vision/ blurred vision/ spots/ flashes

Other rare but serious side effects that you may or may not experience

  • Dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin
  • Ovaries get more stimulated, which can cause very bad stomach pain
  • Sudden and severe headaches

The symptoms of a drug allergy include one or more of the following

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Clomiphene, what precautions must I follow?

​Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant or breastfeeding (ensure negative urine pregnancy test before taking this medication)
  • You have or ever had liver disease
  • You have hormone dependent tumour or abnormal uterine bleeding
  • You have an ovarian cyst (except polycystic ovary)
  • You are taking any other medications, including supplements, traditional medications and herbal remedies.

What food or medicine must I avoid when I take Clomiphene?

Clomiphene - Dosage and How to Use

How should Clomiphene be used?

  • ​Take this medication only as directed by your doctor.
  • This medication is usually taken when you start having your full flow menstruation and after obtaining a negative pregnancy test.
  • Take for 5 days (normally from Day 2 to Day 6 of menstruation), preferably at the same time each day.
  • You can take this medication with or without food. However, if you experience any stomach discomfort after taking the medication on an empty stomach, take it after food.

What should I do if I miss a dose?

​If you forget to take a dose, take it as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.

What should I do if I overdose?

Clomiphene - Handling and Storage

How should I handle Clomiphene safely?

How should I store Clomiphene?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

How should I dispose of Clomiphene safely?

​Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.

Clomiphene - Additional Information

  • Tags: Fertility Drugs (Oral)
  • Updated on Wednesday, July 31, 2019
  • Article contributed by PSS National Medication Information Workgroup

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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