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Clomiphene - What is it for

​Clomiphene is used as a fertility medication in some women who are unable to become pregnant. They work by stimulating the release of eggs from the ovary, causing ovulation to occur. This helps prepare the body for conception.

Clomiphene - Side Effects, Precautions, and Contraindications

What side effects can Clomiphene cause?

Common side effects include:

  • Bloating, nausea and/or vomiting
    • Take the medication after food to reduce these side effects.
  • Hot flushes
    • Wear loose fitting clothes or go to areas with air-conditioning.
  • Dizziness/light-headedness and tiredness
    • Avoid activities that require mental alertness and avoid using heavy machineries.
  • Headache, muscle aches or joint pains
    • You may take Paracetamol to relieve such symptoms (if not allergic to Paracetamol).
Inform your doctor if these side effects become severe and bothersome.

Other rare but serious side effects that you may or may not experience include:

  • Numbness, weakness or paralysis on one side of your body, slurred speech, sudden blurred vision, confusion or unsteadiness.
  • Dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin.
  • Ovaries get more stimulated, which can cause very bad stomach pain and bloating, feeling sick and vomiting, shortness of breath, dehydration and passing less urine.
  • Eyesight changes e.g. blurred vision or seeing spots or flashes. This usually occurs when taking higher doses of the medication or for a long time. Eyesight most often returns to normal when the medication is stopped.
  • Sudden and severe headaches.

The symptoms of a drug allergy include one or more of the following

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Clomiphene , what precautions must I follow?

​Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication.
  • You are pregnant or breastfeeding (ensure negative urine pregnancy test before taking this medication).
  • You are taking any other medications, including supplements, traditional medications and herbal remedies.
  • You have or ever had liver disease.
  • You have hypertriglyceridemia (an excess of a certain fat in the body) or a family history of it.
  • You have hormone dependent tumour (such as breast cancer) or abnormal menstrual bleeding.
  • You have ovarian cysts (except polycystic ovary) or fibroids.
  • You have or ever had fits or seizures.

What food or medicine must I avoid when I take Clomiphene ?

Clomiphene - Dosage and How to Use

How should Clomiphene be used?

  • ​Take this medication only as directed by your doctor.
  • This medication is usually taken when you start having your full flow menstruation and after obtaining a negative pregnancy test.
  • Take for 5 days (normally from Day 2 to Day 6 of menses), preferably at the same time each day.
  • You can take this medication with or without food. 

What should I do if I miss a dose?

​If you forget to take a dose, take it as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.

What should I do if I overdose?

Clomiphene - Handling

How should I handle Clomiphene safely?

Clomiphene - Storage

How should I store Clomiphene ?

;#Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

How should I dispose of Clomiphene safely?

​Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.

Clomiphene - Additional Information

  • Updated on 10/31/2022 12:00:00 AM
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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