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Drug Class: Commonly Known As: Category:
Tricyclic Antidepressants Adult

Imipramine - Side Effects, Precautions, and Contraindications

What side effects can Imipramine cause?

The mentioned side effects generally affect up to 10% of patients.

  • ​Nausea or vomiting or loss of appetite
    • Take the medication with or after food.
    • Take small but frequent meals and avoid fatty or spicy food
  • Drowsiness or feeling tired
    • Avoid driving, or taking part in activities that requires concentration.
    • Discuss with your doctor if you can take your medication at a different time of the day if it affects you.
  • Dry mouth
    • Chew sugar-free gum, suck on sugar-free hard candies or ice chips, sip water regularly
  • Constipation
    • Drink more water (if you do not have any fluid restriction), eat more high- fibre foods, and exercise regularly
    • Consult your doctor or pharmacist if you need medication to relieve your condition.
  • Diarrhoea
    • Drink plenty of water to replace the loss of fluids
  • Dizziness
    • Get up slowly from a sitting or lying down position
  • Mild nervousness
    • May occur at the start of treatment and improves over time
  • Weight gain
    • Exercise regularly and eat a healthy and balanced diet
  • Headache, decreased sexual drive or ability
    • Speak to your doctor if any of these affect your daily life

Most of the side effects listed here will improve with time. Speak with your doctor if they continue, get worse or are affecting your daily life.

Very rarely (affect less than 1% of patients) this medication may cause:

  • Fast or irregular heartbeat
  • Confusion
  • Seeing or hearing things that are not there (hallucnations)
  • Stiffness of arms or legs
  • Problems in urinating
  • Blurred vision
  • Fits (seizures) 
  • Yellowing of skin or eyes, pain in your upper stomach or dark brow urine and/or pale grey/clay-coloured stools (signs and symptoms of liver damage)

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Imipramine , what precautions must I follow?

Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant, planning to become pregnant, or breastfeeding. If you are pregnant and/or breastfeeding, your doctor would have discussed the potential benefits and side-effects with you and should you have further questions or concerns, do consult your doctor.
  • You have or have ever had:
    • Other drug allergies
    • Heart, kidney or liver disease
    • Medical conditions such as difficulty in urination, enlarged prostate gland, overactive thyroid gland (hyperthyroidism), fits (seizures) or glaucoma (increased eye pressure)
    • Other mental health conditions such as bipolar disorder, abnormally high or excited mood (mania) or alcohol abuse
    • Been taking other medications for low mood in the past 2 weeks.

Your skin may become more sensitive to sunlight after starting this medication. Avoid strong sunlight and use sunblock to protect your skin.


If you notice any changes in your mental condition especially in the first few weeks of treatment and during dose changes, you need to check with your doctor immediately. Do watch for any of the following changes in mental condition:

  • New or increasing thoughts of harming yourself
  • Worsening anxiety, restlessness, violent behaviour, or
  • Other changes in mood or behaviour.

Be sure that your family or caregiver are also aware of the above symptoms so they can call your doctor if you are unable to seek treatment on your own.

What food or medicine must I avoid when I take Imipramine ?

​Avoid drinking alcohol while taking this medication as it may make you feel very drowsy. This medication may interact with other medications. If you intend to take any over the counter medication, supplements, herbal remedy or traditional Chinese medicine, consult your doctor or healthcare professional first to confirm that it is safe to take with Imipramine.

Imipramine - Additional Information

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