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Drug Class: Commonly Known As: Category:
Tricyclic Antidepressants Apo-Imipramine

imipramine - Side Effects, Precautions, and Contraindications

What side effects can imipramine cause?

  • ​Nausea
    • Take the medication after food, eat small but frequent meals. Avoid fatty or spicy food.
  • Drowsiness
    • May affect your ability to drive and use machinery. Make sure your reactions are normal before you drive or do things which require you to be alert.
  • Dizziness
    • Get up slowly from a sitting or lying position.
  • Dry mouth
    • Chew sugar-free gum, suck on sugar-free hard candies or ice chips, sip water regularly
  • Constipation
    • Drink more water (if you do not have any fluid restrictions), eat more high-fibre foods, and exercise regularly
  • Dry Eyes
    • Apply lubricant eye drops if necessary.
  • Skin sensitive to sunlight
    • Wear long-sleeved clothing and apply sunblock to protect yourself from the sun.

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

Very rarely (affect less than 1% of patients), this medication may cause:

  • Fast or irregular heartbeat
  • Confusion
  • Hallucinations (seeing or hearing things that are not there)
  • Stiffness of arms or legs
  • Problems in urinating
  • Blurred vision
  • Seizures (fits)
  • Dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking imipramine , what precautions must I follow?

​Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant, planning to become pregnant, or breastfeeding
  • You have heart, liver or kidney problems
  • You have diabetes as this medication may affect blood glucose control
  • You have a history of seizures(fits)
  • You have glaucoma
  • You are taking other medications for your mood
  • You have sudden changes in mood
  • You have new or increasing thoughts of harming yourself
       In some cases, particularly in young people below the age of 25 years, this medication may cause the      following changes to a person's mental condition, especially in the first few weeks of treatment or during dose 
  • New or worsening thoughts of harming yourself or ending your life 
  • Worsening agitation, restlessness, violent behaviour, or 
  • Other changes in mood or behaviour 
   Please inform your doctor as soon as possible, or for your family or caregiver to inform your doctor if 
   you are unable to seek treatment on your own 

  Do not stop taking this medication on your own without discussing with your doctor.

   It is important to note that your doctor has prescribed this medication as he/she feels you will benefit 
   more from taking this medication over the possible risks that it may cause, which have a low chance of 
   occuring, and most people take this medication without any of such problems.  

What food or medicine must I avoid when I take imipramine ?

​Avoid drinking alcohol as it may increase the risk of dizziness, light-headedness or drowsiness.

Inform your healthcare professional if you are taking or intend to take any other medication, supplements, traditional medications or herbal remedies.

imipramine - Additional Information

  • Updated on 9/30/2019 12:00:00 AM
  • Article contributed by PSS National Medication Information Workgroup
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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