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Drug Class: Commonly Known As: Category:
Antineoplastic Thymidine-based Nucleoside Analog + Thymidine Phosphorylase Inhibitor Lonsurf®

Trifluridine/Tipiracil - Side Effects, Precautions, and Contraindications

What side effects can Trifluridine/Tipiracil cause?

  • ​Nausea and vomiting
    • Take small, frequent meals throughout the day.
    • Take the medications for nausea or vomiting as instructed by your doctor if any.
  • Diarrhea
    • Drink plenty of clear fluids to replace those lost (2 litres everyday).
    • Avoid oily or spicy food and milk or dairy products.
  • Slight ache or tenderness around the stomach area
    • Avoid food that causes bloating or gas production in the stomach.
  • Feeling tired and lack of energy
    • Do not drive or operate machinery when you feel tired.
  • Decreased white blood cells, red blood cells and platelets
    • This may put you at higher risk of infections, bleeding or bruising and feeling tired.
    • To reduce your risk of infection:
      • Avoid crowds and people who are sick. Wear a face mask when you are going out.
      • Wash your hands after using the toilet and before handling food.
      • Eat food that is fresh and completely cooked, and avoid raw or half-cooked food.
    • To reduce your risk of bleeding problems:
      • Be careful when using sharp objects such as knives.
      • Try not to bruise, cut or knock yourself.
      • Brush your teeth gently as your gums may bleed more easily.
      • Apply direct pressure to any cuts or wounds to help stop bleeding.

Please see your healthcare professional immediately if any of the following occur:

  • Signs of infection - fever of 38° C and above, chills, cough, body aches
  • Unhealthy pale skin colour, light-headedness, increasing tiredness or weakness
  • Unusual bleeding, bruising, black sticky stools or blood in urine
  • Symptoms of a drug allergy including one or more of the following:
    • Swollen face/eyes/lips/tongue
    • Difficulty in breathing
    • Itchy skin rashes over your whole body

Before taking Trifluridine/Tipiracil, what precautions must I follow?

​Inform your healthcare professional if:

  • You are allergic to this medication
  • You or your partner becomes pregnant or is planning for pregnancy
    • You should use effective birth control during and for 6 months after stopping treatment.
  • You are breastfeeding
    • Do not breastfeed during and for 1 day after the last dose of treatment.
  • You are taking or intending to take any other medication, supplements, traditional medications or herbal remedies

What food or medicine must I avoid when I take Trifluridine/Tipiracil?

Trifluridine/Tipiracil - Additional Information

​You may refer to the following website if you need more information:

  • Updated on Monday, September 30, 2019
  • Article contributed by PSS National Medication Information Workgroup

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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