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Molecular Genotyping of Hydatiform Mole (Fragment Analysis)

Test Code:

HT0202

Synonym(s):

 

Specimen Container

FFPE block / unstained slide / FRESH

Specimen Requirement

 1. Formalin-Fixed Paraffin-Embedded block or
2. 10x unstained sections and 1 corresponding H&E slide.
 
Maternal and villus tissues should be available in the provided samples.
 
Tissue must be non-necrotic, non-cauterised, and must not have undergone acid-based decalcification. Improper storage conditions may additionally compromise nucleic acid integrity.

Specimen Storage / Transport

Method

 

Orderable as STAT?

No

Turn Around Time

3 working days; Batch run every Tuesday

Reference Value(s)

Testing Laboratory Location

KKH

Laboratory

Molecular Histopathology

Contact Number

6394 1380

Day and Time Performed

Mon – Fri: 0800 hrs– 1700 hrs

Orderable on CPOE?

Yes

Downtime Form

Additional Information

Accurate diagnosis and classification of molar pregnancy is important for determining risk of subsequent gestational trophoblastic neoplasia and subsequent patient follow-up. Diagnosis is traditionally performed by histopathological examination of products of conception (POC), and is challenging in early molar pregnancies even with ancillary techniques like p57kip2 immunohistochemistry.Here, we offer a polymerase chain reaction (PCR)-based short tandem repeat (STR) DNA genotyping assay for genetic diagnosis of partial and complete moles.

Expected Test Result: Complete mole; Partial mole; Non-molar pregnancy

The molecular test result must always be correlated with clinical and histopathological findings by an appropriately trained, qualified and experienced pathologist.
 
Quality Assurance: Internal Quality Assurance (KKH DPLM)

Change History Notes

Others

Keywords

Molecular Genotyping of Hydatiform Mole (Fragment Analysis) HT0202
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