TERT C228T Mutational Analysis (Sanger Sequencing) (DISCONTINUED)

Test Code:

XXXXX

Synonym(s):

Specimen Container

Specimen Requirement

1. Formalin-Fixed Paraffin-Embedded block or

2. 10x unstained sections and 1 corresponding H&E slide.

Tissue must be non-necrotic, non-cauterised, and must not have undergone acid-based decalcification. Improper storage conditions may additionally compromise nucleic acid integrity.

Specimen Storage / Transport

Method

Orderable as STAT?

Turn Around Time

7 working days

Reference Value(s)

Testing Laboratory Location

KKH

Laboratory

Molecular Histopathology

Contact Number

6394 1402

Day and Time Performed

Mon – Fri: 0800 hrs – 1700 hrs

Orderable on CPOE?

Downtime Form

Molecular Histopathology

Additional Information

TERT C228T promoter mutation in the primary tumour was associated with a significant difference in overall survival in patients with adult granulosa cell tumour (aGCT) (p = 0.00253, log-rank test). The TERT C228T promoter mutations may have an important role in progression of aGCT which, when present in the primary tumour, can help identify cases with increased risk of recurrence. The absence of the mutation does not preclude recurrence.

Expected Results:
TERT C228T mutation is detected/not detected.

Quality Assurance: Internal Quality Assurance (KKH DPLM)

HT0201