TERT C228T Mutational Analysis (Sanger Sequencing) (DISCONTINUED)

Specimen Requirement	1. Formalin-Fixed Paraffin-Embedded block or 2. 10x unstained sections and 1 corresponding H&E slide. Tissue must be non-necrotic, non-cauterised, and must not have undergone acid-based decalcification. Improper storage conditions may additionally compromise nucleic acid integrity.
Orderable as Urgent?	No
Turn Around Time	7 working days
Testing Laboratory Location	KKH
Laboratory	Molecular Histopathology
Contact Number	6394 1402
Day and Time Performed	Mon – Fri: 0800 hrs – 1700 hrs
Orderable on CPOE?	No
Downtime Form	Molecular Pathology
Additional Information	TERT C228T promoter mutation in the primary tumour was associated with a significant difference in overall survival in patients with adult granulosa cell tumour (aGCT) (p = 0.00253, log-rank test). The TERT C228T promoter mutations may have an important role in progression of aGCT which, when present in the primary tumour, can help identify cases with increased risk of recurrence. The absence of the mutation does not preclude recurrence. Expected Results: TERT C228T mutation is detected/not detected. Quality Assurance: Internal Quality Assurance (KKH DPLM) HT0201

Last Updated - 27 Jun 2025