Whole Blood EDTA3 mL
Between 8 am to 9 am on Monday only, collect 3 mL of fresh blood from patient
and despatch immediately to DPLM Client Service. Specimen is not to be collected
on Tuesday to Sunday, eve of public holidays and public holidays.
Keep specimen at room temperature. DO
NOT send on ice or refrigerant. Despatch to KKH DPLM Client Services as soon as
possible as blood must reach NUH by 12 noon.
Monday only except for Public
Holidays and eves of Public Holiday, between 8 to 9 am.
Patients should abstain from the following drugs for at least 48 hours prior
to TPMT testing: naproxen (Aleve), ibuprofen (Advil, Motrin), ketoprofen
(Orudis), furosemide (Lasix), sulfasalazine (Azulfidine), mesalamine (Asacol),
olsalazine (Dipentum), mefenamic acid (Ponstel), trimethoprim (Proloprim),
methotrexate, thiazide diuretics, and benzoic acid inhibitors.
This test is useful for the detection of individuals with low thiopurine
methyltransferase (TPMT) activity who are at risk for excessive myelosuppression
or severe hematopoietic toxicity when taking thiopurine drugs.
Detection of individuals with hyperactive TPMT activity who have therapeutic
resistance to thiopurine drugs and may develop hepatotoxicity if treated with
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