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Rasburicase can cause enzymatic degradation of uric acid in blood samples, resulting in falsely low uric acid concentrations. To minimise ex vivo degradation of uric acid in blood samples from patients treated with rasburicase, please (1) collect blood into a pre-chilled specimen tube, (2) send it immediately to the laboratory on ice by hand and (3) alert Clinical Chemistry laboratory to analyse the specimen as soon as possible.
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