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Asst Prof Loh Hong Pheng Amos

Amos Loh Hong Pheng

Asst Prof Loh Hong Pheng Amos

MBBS, MRCS (Edinburgh), MMed (Surg), FAMS (Paeds Surgery)

Senior Consultant

KK Women's and Children's Hospital

Specialty: Paediatric Surgery

Sub-specialties: Paediatric Surgical Oncology, Minimally Invasive Surgery, Vascular Anomalies

Clinical Appointments

  • Deputy Chairman Division of Surgery KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Senior Consultant SingHealth Duke-NUS Vascular Centre
  • Senior Consultant Children's Surgery Centre KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Senior Consultant Paediatric Brain and Solid Tumour Programme KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Deputy Director KK Research Centre KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Visiting Consultant Neonatal and Developmental Medicine Singapore General HospitalSingapore General Hospital

Academic Appointments

  • Director, Clinician Scientist Development Office, Surgery SingHealth Duke-NUS Surgery Academic Clinical Programme

Profile

Dr Amos Loh is a Senior Consultant at the Department of Paediatric Surgery, KK Women’s and Children’s Hospital, and Assistant Professor at the Duke NUS Medical School. He is also Principal Investigator of the VIVA-KKH Paediatric Solid Tumour Research Laboratory and Chairman of the VIVA-KKH Paediatric Brain and Solid Tumour Programme, and has a clinical practice and academic research focus in c.

Dr Loh obtained his medical degree from the National University of Singapore in 2002. He trained subsequently in general and paediatric surgery, and was awarded the Academy of Medicine Singapore College of Surgeons Gold Medal in paediatric surgery. He pursued a paediatric surgical oncology fellowship and a research fellowship at St Jude Children’s Research Hospital, for which he was awarded a National Medical Research Council research training award.

His academic interests are in clinical and translational research in paediatric solid tumours, in particular, patient-derived preclinical models of paediatric solid tumors, and novel biomarker discovery for prognostication and therapeutic stratification.

Education

  • FAMS (Paeds Surgery) 2011
  • MMed (Surgery) National University of Singapore 2007
  • MRCSEd 2006
  • MBBS National University of Singapore 2002

Professional Appointments and Committee Memberships

  • Principal Investigator, VIVA-KKH Paediatric Solid Tumour Research Laboratory KK Women's and Children's Hospital
  • Assistant Professor, Duke-NUS Medical School 2017 - 2019
  • Chairman, VIVA-KKH Paediatric Brain and Solid Tumour Programme 2015 - Present
  • Chairman, Paediatric Oncology Group Singapore 2016 - 2018
  • Director, Clinician Scientist Development Office, Surgery ACP 2016 - Present
  • Committee Member, Academy of Medicine, Singapore (Chapter of Paediatric Surgeons), 2017 - 2018
  • Fellow, Academy of Medicine, Singapore (Chapter of Clinician Scientists), 2017 - Present
  • Member, International Society of Paediatric Oncology Europe Neuroblastoma (SIOPEN) 2016 - Present
  • Member, International Society of Paediatric Oncology Europe Liver (SIOPEL) 2016 - Present
  • Member, SIOP Renal Tumour Study Group, 2016 - Present
  • Principal Investigator, VIVA-KKH Paediatric Solid Tumour Research Lab 2016 - Present
  • Scientific Co-Chairman, St Jude-VIVA Forum on Paediatric Oncology 2015 - Present
  • Engagement Committee Chairman, SingHealth Surgical Congress Organizing Committee 2017
  • Full Member, Advances in Neuroblastoma Research Association 2015 - Present
  • Member, Sarcoma Symposium Organizing Committee 2015 - Present
  • Co-Director, Clinician Scientist Development Office, Surgery ACP 2015 - 2016
  • Scientific Co-Chairman, SingHealth Surgical Congress Organizing Committee 2015
  • Member, Infectious Disease Oncology Surveillance Subcommittee, KKH 2014 - Present
  • Member, St Jude-Viva Forum Organizing Committee, 2014
  • Consultant, Department of Paediatric Surgery, KKH 2014
  • Co-Convener, Paediatric Surgery Exit Examination 2014
  • Fellow, International College of Surgeons 2013 - Present
  • Member, International Society of Pediatric Surgical Oncology 2013 - Present
  • Member, Paediatric Surgery AST Curriculum Workgroup 2013
  • Member, Institutional Review Board, St Jude Children’s Research Hospital, 2013 - 2014
  • Member, Operating Room Committee, St Jude Children’s Research Hospital, 2011 - 2013
  • Member, Serious Reportable Events Quality Assurance Committee, KKH 2011 - 2012
  • Fellow, Academy of Medicine, Singapore (Chapter of Paediatric Surgeons) 2011 - Present
  • Visiting Consultant, Neonatology, SGH 2011 - Present
  • Member, Paediatric Oncology Group Singapore 2011 - Present
  • Member, Integrated Health Information Systems (IHIS) Committee, KKH, 2009 - 2010
  • Secretary, Paediatric Oncology Group Singapore 2008 - 2010
  • Member, Royal College of Surgeons of Edinburgh 2006 - Present

Awards

  • Best Poster (Clinical Research), 9th KKH Scientific Meeting, KKH 2017
  • Collaboration Award, 9th KKH Scientific Meeting, KKH 2017
  • Best Oral Paper, 9th KKH Scientific Meeting, KKH 2017
  • Singapore Health Quality Service Award, 2015
  • Best poster, 2015 Asia Pacific Symposium of Neuroblastoma, Taipei, Taiwan 2015
  • SingHealth Publish! Award (Medical Research), SingHealth, 2015
  • Outstanding Clinical Teacher Award, KKH 2015
  • Best paper, 47th Annual Congress of International Society of Pediatric Oncology (SIOP) (IPSO Chapter), Cape Town, South Africa, 2015
  • SingHealth Publish! Award (Medical Research), SingHealth Foundation, 2013
  • NMRC Research Training Fellowship (Overseas Research Attachment), National Medical Research Council, 2012
  • College of Surgeons Gold medal in Paediatric Surgery, Academy of Medicine, 2011
  • Best poster, 43rd Annual Congress of International Society of Pediatric Oncology (SIOP), Auckland, New Zealand, 2011
  • Best paper, 42nd Annual Congress of International Society of Pediatric Oncology (SIOP) (IPSO Chapter), Sao Paulo, Brazil, 2009

Research Interests

  • Preclinical models of paediatric solid tumours, particularly for preclinical testing of novel therapeutic strategies and co-clinical personalized medicine applications
  • Novel biomarker discovery for prognostication and therapeutic stratification, particularly for neuroblastoma and Wilms tumour
  • Circulating tumour cells and microscopic residual disease in paediatric solid tumours
  • Preoperative malignancy risk prediction in paediatric ovarian tumours
  • Clinical outcomes research in paediatric surgical oncology

Publications

  • Clinical management of pheochromocytoma and paraganglioma in Singapore: missed opportunities for genetic testing.Chew WHW, Courtney E, Lim KH, Li ST, Chen Y, Tan MH, Chung A, Khoo J, Loh A, Soh SY, Iyer P, Loh LM, Ngeow J.Mol Genet Genomic Med. 2017 Jul 20;5(5):602-607.
  • Clear cell sarcomas of the kidney are characterised by BCOR gene abnormalities, including exon 15 internal tandem duplications and BCOR-CCNB3 gene fusion.Wong MK, Ng CCY, Kuick CH, Aw SJ, Rajasegaran V, Lim JQ, Sudhanshi J, Loh E, Yin M, Ma J, Zhang Z, Iyer P, Loh AHP, Lian DWQ, Wang S, Goh SGH, Lim TH, Lim AST, Ng T, Goytain A, Loh AHL, Tan PH, Teh BT, Chang KTE. Histopathology. 2018 Jan;72(2):320-329. JIF 3.453
  • Management of a Kaposiform haemangioendothelioma of the kidney with Kasabach-Meritt phenomenon without chemotherapy. New MS, Ong MW, Lam JCM, Chang KTE, Fortier MV, Wijeweera O, Tan AM, Loh AHP. Pediatr Hematol Oncol J. 2016 Oct; 1(4):89-92.
  • Re: External validation of the Paediatric Risk of Malignancy Index. Loh AH*, Lee YT, Lam SL, Ong CL. BJOG. 2016 Jul;123(8):1399.
  • XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis. Choo Z, Koh RY, Wallis K, Koh TJ, Kuick CH, Sobrado V, Kenchappa RS, Loh AH, Soh SY, Schlisio S, Chang KT, Chen ZX. Oncotarget. 2016 Apr 15.
  • Initial diagnostic management of pediatric bone tumors. Interiano RB, Malkan AD, Loh AH, Hinkle N, Wahid FN, Bahrami A, Mao S, Wu J, Bishop MW, Neel MD, Gold RE, Rao BN, Davidoff AM, Fernandez-Pineda I.. J Pediatr Surg. Epub 2016 Mar 2
  • Thyroglossal duct cyst carcinoma: diagnostic and management considerations in a 15 year old with a large submental mass. Seow-En I, Loh AHP, Lian DWQ, Nah S. BMJ Case Rep. Epub 2015 Jul 6.
  • Systematic screening identifies dual PI3K and mTOR inhibition as a conserved therapeutic vulnerability in osteosarcoma. Gupte A, Baker W, Wan S, Stewart E, Loh A, Shelat A, Gould C, Chalk A, Taylor S, Lackovic K, Karlstrom A, Mutsaers A, Desai J, Madhamshettiwar P, Zannettino A, Burns C, Huang D, Dyer M, Simpson K, Walkley C. Clin Cancer Res. 2015 Jul 15;21(14):3216-29. Epub 2015 Apr 10.
  • Novel karyotypes and cyclin D1 immunoreactivity in clear cell sarcoma of the kidney. Aw SJ, Wang S, Loh AH, Kuick CH, Lian DW, Yong MH, Ling S, Peh GL, Soh SY, Loh AH, Tan PH, Chang KT. Pediatr Dev Pathol. 2015 Jul-Aug;18(4):297-304. Epub 2015 Mar 9.
  • Oncological Surgery in Children. In: Surgery: Core Principles & International Practice (Section 7, Chapter 5). JD Corson, RCN Williamson (eds). Loh AH, Davidoff AM. 2nd edition, Jaypee Medical Publishers, May 20 2015
  • Soft Tissue Sarcomas. In: Pediatric Surgery (Springer Atlas Series). P Puri, ME Hollwarth (ed). Loh AH, Rao BN. 2nd edition, Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2015
  • Central Venous Access Devices in Oncology Patients. In: The Baby Bear Book: A Practical Guide on Paediatrics. SY Soh, S Jamuar, J Puthucheary (eds). Soh SY, Loh A, Toh L, Pham TNA, Chong CY. 3rd edition, Red Cells Series, SingHealth Academy, 2015.
  • An Approach to Renal Masses in Pediatrics. Malkan A, Loh AH, Bahrami A, Navid F, Coleman J, Green D, Davidoff AM, Sandoval JA. Pediatrics. 2015 Jan;135(1):142-58. Epub 2014 Dec 1. JIF 5.47
  • Long-term Physiologic and Oncologic Outcomes of Inferior Vena Cava Thrombosis in Pediatric Malignant Abdominal Tumors. Loh A, Bishop M, Krasin M, Davidoff AM, Langham MR Jr. J Pediatr Surg. 2015 Apr;50(4):550-5. Epub 2014 Dec 2.
  • Safety and Diagnostic Accuracy of Tumor Biopsies in Children with Cancer. Interiano RB / Loh AH, Hinkle N, Wahid FN, Malkan A, Bahrami A, Jenkins JJ, Mao S, Wu J, Proctor K, Santana VM, Pappo AS, Gold RE, Davidoff AM. Cancer. 2015 Apr 1;121(7):1098-107. Epub 2014 Dec 18.
  • Influence of Bony Resection Margins and Surgicopathological Factors on Outcomes in Limb-Sparing Surgery for Extremity Osteosarcoma. Loh AH, Wu H, Bahrami A, Navid F, McCarville MB, Wang C, Wu J, Bishop MW, Daw NC, Neel MD, Rao BN. Pediatr Blood Cancer. 2014 Epub 2014 Nov 8.
  • The Role of Thoracoscopic Surgery in Pediatric Oncology. Malkan AD, Loh AH, Fernandez-Pineda I, Sandoval JA. J Laparoendosc Adv Surg Tech A. 2014 Nov;24(11):819-26. Epub 2014 Oct 7. JIF 1.335
  • Targeting the DNA Repair Pathway in Ewing Sarcoma. Stewart E, Goshorn R, Bradley C, Griffiths LM, Benavente C, Twarog N, Miller GM, Caufield W, Freeman BB, Bahrami A, Pappo A, Wu J, Loh A, Karlström Å, Calabrese C, Gordon B, Tsurkan L, Hatfield MJ, Potter PM, Snyder SE, Thiagarajan S, Shirinifard A, Sablauer A, Shelat AA, Dyer MA. Cell Reports. 2014 November 6;9(3):829-40. Epub 2014 Oct 23.
  • Minimally invasive surgery in the management of abdominal tumors in children. Malkam A, Loh AH, Sandoval JA. J Pediatr Surg. 2014 Jul;49(7):1171-1176. Epub 2014 May 22. JIF 1.311
  • Rhabdomyosarcoma. In: Encyclopedia of Pediatric Surgery (Volume 2), P Puri (ed). Loh AH, Rao BN. 1st edition, Springer-Verlag Berlin and Heidelberg GmbH & Co. K, Apr 30 2014.
  • Management of Local Recurrence of Pediatric Osteosarcoma Following Limb-Sparing Surgery. Loh AH, Navid F, Wang C, Bahrami A, Wu J, Neel MD, Rao BN. Ann Surg Oncol. 2014 Jun;21(6):1948-55. Epub 2014 Feb 21.
  • Diagnostic accuracy of pre-operative alpha-fetoprotein as an ovarian tumor marker in children and adolescents - not as good as we thought? Loh AH*, Gee KW, Chua JH. Pediatr Surg Int. 2013 Jul;29(7):709-13. Epub 2013 May 8.
  • Dissecting the PI3K Signaling Axis in Pediatric Solid Tumors: Novel Targets for Clinical Integration. Loh AH, Brennan RC, Lang W, Hickey RJ, Malkas LH, Sandoval JA. Front Oncol. 2013 Apr;23;3:93. doi:10.3389/fonc.2013.00093.
  • Pediatric risk of malignancy index for preoperative evaluation of childhood ovarian tumors. Loh AH*, Ong CL, Lam SL, Chua JH, Chui CH. Pediatr Surg Int. 2012 Mar;28(3):259-66. Epub 2011 Dec 8.
  • Diagnostic delay in pediatric solid tumors: A population based study on determinants and impact on outcomes. Pediatr Blood Cancer. Loh AH*, Aung L, Ha C, Tan AM, Quah TC, Chui CH. Pediatr Blood Cancer. 2012 Apr;58(4):561-5. Epub 2011 Nov 2.
  • Neonatal ovarian cysts: role of sonography in diagnosing torsion. Chinchure D, Ong CL, Loh AH, Rajadurai VS. Ann Acad Med Singapore. 2011 Jun;40(6):291-5.
  • Gene expression of TRK neurotrophin receptors in advanced neuroblastomas in Singapore--a pilot study. Fung W, Hasan MY, Loh AH, Chua JH, Hwee YM, Knight L, Sek HW, Yoke CM, Tew SW, Jacobsen AS, Hon CC. Pediatr Hematol Oncol. 2011 Oct;28(7):571-8. Epub 2011 Jul 5.
  • Delays in Diagnosis of Paediatric Tumours in Singapore. Loh AH, Ha C, Chua JHY, WT Seow, MY Chan, AM Tan, Chui CH. J Pediatr Hematol Oncol. 2009 Oct;31(10):734-8
  • Presentation and Progression of Benign Prostatic Hyperplasia: A Singapore Experience Profiling Differences in a Multi-Racial Study Cohort. Loh AH, Ng KK, Ng FC. Annals Acad Med Singapore 2009;38(5):451-6
  • The Diagnostic, Prognostic and Therapeutic Roles of Trk Neurotrophin Receptors (Trks) Expressions in Neuroblastoma. Fung WKY, Loh AH, Yong MY, Knight L, Hwang WS, Chan MY, Seow WT, Chui CH, Jacobsen AS. KK Hospital. Review 2008 Dec;11(2):71-74
  • Use of Multiplex RT-PCR Assay for Evaluating the Significance of Trk Neurotrophin Receptors Gene Expression In Children with Neuroblastoma in Singapore Between 2003-2007. Fung WKY, Loh AH, Yong MH, Knight L, Hwang WS, Chan MY, Soh SY, Tan AM, Seow WT, Chui CH, Jacobsen AS. KK Hospital Review 2008 Dec;11(2):68-70
  • Port-A-Cath Insertions in Acute Leukaemia: Does Thrombocytopaenia Affect Morbidity? Loh AH, Chui CH. J Pediatr Surg 2007 Jul;42(7):1180-4
  • Port-A-Cath Insertions in Acute Leukaemia and Childhood Malignancies. Loh AH, Chui CH. Asian J Surg 2007 Jul;30(3):193-9
  • Neonatal Intestinal Volvulus Due to A Persistent Right Vitelline Artery. Loh AH, Prasad ST, Chew SH, Jacobsen AS. Pediatr Surg Int. 2007 Apr;23(4):373-6

Research Trials

  • Modelling, Analysis and Translational Therapeutics for Tumours of Childhood (MAT3CH)
  • Longitudinal Assessment of Biomarkers for Treatment-response Evaluation in Solid Tumours (LABTEST)