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Asst Prof Amos Loh Hong Pheng

Asst Prof Amos Loh Hong Pheng

MBBS, MRCS (Edinburgh), MMed (Surg), FAMS (Paeds Surgery)

Senior Consultant

KK Women's and Children's Hospital

Specialty/Department: Paediatric Surgery

Clinical Interest: Paediatric Surgical Oncology, Paediatric Surgery, Minimally Invasive Surgery

Conditions Treated by this Doctor:
Acute Appendicitis, Bladder Cancer, Colorectal Cancer, Gastric Cancer, Head and Neck Cancer, Hernias ＆ Hydrocoele (Child), Inguinal Hernia (Child), Kidney Cancer, Kidney Swelling - Hydronephrosis, Liver Tumours, Lung Cancer, Lymphoma Cancer, Musculoskeletal Tumours, Ovarian Cancer, Pancreas Cancer, Prostate Cancer, Sarcoma, Skin Cancer, Stomach (Gastric) Cancer, Testicular Cancer.

Clinical Appointments

  • Chairman Division of Surgery KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Senior Consultant Children's Surgery Centre KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Senior Consultant Children's Blood and Cancer Centre KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Senior Consultant Paediatric Brain and Solid Tumour Programme KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Visiting Consultant Neonatal and Developmental Medicine Singapore General HospitalSingapore General Hospital

Academic Appointments

  • Assistant Professor SingHealth Duke-NUS Medicine Academic Clinical Programme
  • Deputy Research Director, KK Research Centre
  • Principal Investigator, VIVA-KKH Paediatric Solid Tumour Research Laboratory
  • Chairman, VIVA-KKH Paediatric Brain and Solid Tumour Programme, KKH Children’s Blood and Cancer Centre
  • Chairman, Philanthropy, Surgery Academic Clinical Programme

Profile

Dr Amos Loh is Chairman of the Division of Surgery and Senior Consultant at the Department of Paediatric Surgery, KK Women's and Children's Hospital, and Assistant Professor at the Duke NUS Medical… View More +

Education

  • FAMS (Paeds Surgery) 2011
  • MMed (Surgery) National University of Singapore 2007
  • MRCSEd 2006
  • MBBS National University of Singapore 2002

Professional Appointments and Committee Memberships

  • Co-Chairman, KKH Maternal and Child Health (MCH) Research Committee, 2023 - Present
  • Member, Medical Board, KK Women’s and Children’s Hospital 2021 – Present
  • Deputy Research Director, Hospital Research Committee 2019 – Present
  • Member, JCST Residency Advisory Committee (Paediatric Surgery) 2021 – Present
  • Chairman, Chapter of Paediatric Surgeons, Academy of Medicine, Singapore 2021 – Present
  • Regional Advisory Committee, St Jude Global Alliance Asia Pacific Region 2021 – 2023
  • Assistant Professor, Duke-NUS Medical School 2017 - 2019
  • Chairman, VIVA-KKH Paediatric Brain and Solid Tumour Programme 2015 - Present
  • Chairman, Paediatric Oncology Group Singapore 2016 - 2018
  • Director, Clinician Scientist Development Office, Surgery ACP 2016 - Present
  • Committee Member, Academy of Medicine, Singapore (Chapter of Paediatric Surgeons), 2017 - 2018
  • Fellow, Academy of Medicine, Singapore (Chapter of Clinician Scientists), 2017 - Present
  • Member, International Society of Paediatric Oncology Europe Neuroblastoma (SIOPEN) 2016 - Present
  • Member, International Society of Paediatric Oncology Europe Liver (SIOPEL) 2016 - Present
  • Member, SIOP Renal Tumour Study Group, 2016 - Present
  • Principal Investigator, VIVA-KKH Paediatric Solid Tumour Research Lab 2016 - Present
  • Scientific Co-Chairman, St Jude-VIVA Forum on Paediatric Oncology 2015 - Present
  • Engagement Committee Chairman, SingHealth Surgical Congress Organizing Committee 2017
  • Full Member, Advances in Neuroblastoma Research Association 2015 - Present
  • Member, Sarcoma Symposium Organizing Committee 2015 - Present
  • Co-Director, Clinician Scientist Development Office, Surgery ACP 2015 - 2016
  • Scientific Co-Chairman, SingHealth Surgical Congress Organizing Committee 2015
  • Member, Infectious Disease Oncology Surveillance Subcommittee, KKH 2014 - Present
  • Member, St Jude-Viva Forum Organizing Committee, 2014
  • Consultant, Department of Paediatric Surgery, KKH 2014
  • Co-Convener, Paediatric Surgery Exit Examination 2014
  • Fellow, International College of Surgeons 2013 - Present
  • Member, International Society of Pediatric Surgical Oncology 2013 - Present
  • Member, Paediatric Surgery AST Curriculum Workgroup 2013
  • Member, Institutional Review Board, St Jude Children’s Research Hospital, 2013 - 2014
  • Member, Operating Room Committee, St Jude Children’s Research Hospital, 2011 - 2013
  • Member, Serious Reportable Events Quality Assurance Committee, KKH 2011 - 2012
  • Fellow, Academy of Medicine, Singapore (Chapter of Paediatric Surgeons) 2011 - Present
  • Visiting Consultant, Neonatology, SGH 2011 - Present
  • Member, Paediatric Oncology Group Singapore 2011 - Present
  • Member, Integrated Health Information Systems (IHIS) Committee, KKH, 2009 - 2010
  • Secretary, Paediatric Oncology Group Singapore 2008 - 2010
  • Member, Royal College of Surgeons of Edinburgh 2006 - Present
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Awards

  • Best oral poster (Novel prognostic factors), 54th Annual Congress of International Society of Pediatric Oncology (SIOP), 2022
  • Singapore Health Quality Service Award Gold, 2019
  • Distinguished Young Leader Award, SingHealth Excellence Awards 2018
  • Best Poster (Clinical Research), 9th KKH Scientific Meeting, KKH 2017
  • Collaboration Award, 9th KKH Scientific Meeting, KKH 2017
  • Best Oral Paper, 9th KKH Scientific Meeting, KKH 2017
  • Singapore Health Quality Service Award, 2015
  • Best poster, 2015 Asia Pacific Symposium of Neuroblastoma, Taipei, Taiwan 2015
  • SingHealth Publish! Award (Medical Research), SingHealth, 2015
  • Outstanding Clinical Teacher Award, KKH 2015
  • Best paper, 47th Annual Congress of International Society of Pediatric Oncology (SIOP) (IPSO Chapter), Cape Town, South Africa, 2015
  • SingHealth Publish! Award (Medical Research), SingHealth Foundation, 2013
  • NMRC Research Training Fellowship (Overseas Research Attachment), National Medical Research Council, 2012
  • College of Surgeons Gold medal in Paediatric Surgery, Academy of Medicine, 2011
  • Best poster, 43rd Annual Congress of International Society of Pediatric Oncology (SIOP), Auckland, New Zealand, 2011
  • Best paper, 42nd Annual Congress of International Society of Pediatric Oncology (SIOP) (IPSO Chapter), Sao Paulo, Brazil, 2009
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Research Interests

  • Preclinical models of paediatric solid tumours, particularly for preclinical testing of novel therapeutic strategies and co-clinical personalized medicine applications
  • Novel biomarker discovery for prognostication and therapeutic stratification, particularly for neuroblastoma and Wilms tumour
  • Circulating tumour cells and microscopic residual disease in paediatric solid tumours
  • Preoperative malignancy risk prediction in paediatric ovarian tumours
  • Clinical outcomes research in paediatric surgical oncology

Publications

  • Histone variant H3.3 promotes metastasis in alveolar rhabdomyosarcoma. N Karthik, JJH Lee, JLJ Soon, AHP Loh, DST Ong, WL Tam, RTaneja. J Pathol. 2022 Dec 27. JIF: 9.883
  • Pro-Metastatic and Mesenchymal Gene Expression Signatures Characterize Circulating Tumor Cells of Neuroblastoma Patients with Bone Marrow Metastases and Relapse. AHP Loh, C Angelina, MK Wong, SH Tan, SA Sukhatme, T Yeo, SB Lim, YT Lee, SY Soh, W Leung, KTE Chang, YW Chua, SMF Alkaff, TKH Lim, CT Lim, ZX Chen. Frontiers in Oncology. 2022 Sep 13;12:939460. JIF: 5.738
  • Mutations of 1p genes do not consistently abrogate tumor suppressor functions in 1p-intact neuroblastoma. CH Kuick, JY Tan, D Jasmine, T Sumanty, A Ng, B Venkatesh, H Chen, E Loh, S Jain, WY Seow, E Ng, D Lian, SY Soh, K Chang, ZX Chen*, A Loh* (co-corresponding authors). BMC Cancer. 2022 Jun 30;22(1):717. JIF: 4.372
  • Senescent Langerhans cell histiocytosis cells arise from both dendritic cell (DC) and monocyte/DC3 lineages. E Kvedaraite, A Khalilnezhad, M Chevrier, P Milne, HK Lee, D Hagey, T von Bahr Greenwood, N Lee, L Minnerup, Tan Y, CA Dutertre, N Benac, YY Hwang, J Lum, AHP Loh, KWW Teng, S Khalilnezhad, Xu W, A Resteu, HL Tey, LG Ng, A Larbi, S Wu Howland, S EL Andaloussi, J Braier, G Rassidakis, L Galluzzo, A Dzionek, M Collin, JI Henter, J Chen, F Ginhoux. Sci Immunol. 2022 Dec 23;7(78):eadd3330. JIF: 30.63
  • Mitochondrial calcium uptake regulates tumour progression in embryonal rhabdoyosarcoma. HY Chiu, AHP Loh, R Taneja. Cell Death & Disease. 2022 Apr 30;13(4):419. JIF: 8.469
  • Nephron-Sparing Surgery and Surgical Management of Intravascular Extension of Wilms Tumor. ET Tracy, S Vasconcelos-Castro, M Malogolowkin, AHP Loh, M Kotagal, RD Glick, S Warmann, ML de Pinho Apezzato, NG Cost, J Godzinski. Pediatr Blood Cancer 2023 (in press) JIF: 3.838
  • Generation and Multi-Dimensional Profiling of a Childhood Cancer Cell Line Atlas Defines New Therapeutic Opportunities. C Sun, P Daniel, G Bradshaw, M Loi, N Chew, H Shi, S Parackal, M Koptyra, S Adjumain, C Sun, WC Chong, D Fernando, C Drinkwater, M Tourchi, D Habarakada, D Sooraj, D Carvalho, E Fernandez, H Nguyen, M Porksen, A Doan, D Crombie, M Panday, M Dun, L Ludlow, B Day, B Stringer, N Neeman, J Rubens, EH Raabe, M Vinci, J Fletcher, P Ekert, B Dumesvska, M Tsoli, NF Syed Sulaiman, AHP Loh, SYY Low, A Sweet-Cordero, M Monje, A Resnick, C Jones, B Williams, J Rosenbluh, F Gough, J Cain, R Firestein. Cancer Cell 2023 (in press) JIF: 38.58
  • Aggressive Pursuit of No Evidence of Disease Status in Hepatoblastoma Improves Survival. Fleming AM, Murphy AJ, Sarvode Mothi S, Interiano RB, Loh A, McCarville ME, Abramson Z, Mansfield SA, Abdelhafeez AH, Davidoff AM, Gosain A, Gartrell JA, Furman WL, Langham MR. J Pediatr Surg. 2023. (in press)
  • Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic. Global Health Research Group on Children’s Non-Communicable Diseases Collaborative (among authors: AHP Loh) BMJ Glob Health. 2022 Oct;7(10):e008797. JIF: 8.061
  • Extravesical Versus Intravesical Ureteric Reimplantation for Primary Vesicoureteral Reflux: A Systematic Review and Meta-Analysis. Z Law, CCP Ong, TL Yap, AHP Loh, U Philip, S Sim, L Ong, Y Low, AS Jacobsen, Y Chen. Frontiers in Pediatrics. 2022 Oct 21;10:935082 JIF:3.569
  • Impact of the COVID-19 pandemic on paediatric patients with cancer in low-income, middle-income and high-income countries: protocol for a multicentre, international, observational cohort study. Global Health Research Group on Children’s Non-Communicable Diseases Collaborative (among authors: AHP Loh) BMJ Open. 2022 Jun 2;11(6):e045679. doi: 10.1136/bmjopen-2020-045679. JIF: 2.692
  • The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma. CW Kang, KM Hannan, AC Blackburn, AHP Loh, Kuick CH, Goh JY, N Hein, D Drygin, RD Hannan, LA Coupland. Investigational New Drugs. 2022 Feb 24. doi: 10.1007/s10637-022-01222-w. JIF: 3.85.
  • Predictors and Treatment Outcomes of Pediatric Osteosarcoma in Diverse Socioeconomic Backgrounds in Southeast Asia: A Retrospective Multicenter Study. C Monsereenusorn, AP Alcasabas, AHP Loh, SY Soh, KWP Leung, C Dhamne, S Blair, C Lam, P Rujkijyanont, C Traivaree, A Photia, P Veerapan, ME Puhaindran, BLZ Oh, E Wang, C Rodriguez-Galindo. Asian Pacific Journal of Cancer Prevention. 2022 Feb 1;23(2):631-640. JIF: 1.77 
  • Impact of Treatment Refusal and Abandonment Incorporate with Survival Outcomes in Pediatric Osteosarcoma in Southeast Asia: Multicenter Study. C Monsereenusorn, AP Alcasabas, AHP Loh, SY Soh, KWP Leung, C Dhamne, S Blair, C Lam, P Rujkijyanont, C Traivaree, A Photia, P Veerapan, ME Puhaindran, BLZ Oh, EHM Wang, C Rodriguez-Galindo, Asian Childhood Cancer Alliance Osteosarcoma Study Group. Pediatric Blood and Cancer. 2022 Apr;69(4):e29556. JIF: 3.838
  • Neuroblastoma. A Loh, DS Harrison, JT Michael, C Martucci, A Crocoli, S Avanzini, L Matthyssens, HD Le, R Rizzo, A Yoneda, SA Vega-Salas, C Grant, L Pio. In: de Campos Vieira Abib Simone, Chui Chan Hon, Cox Sharon, Abdelhafeez Abdelhafeez H, Fernandez-Pineda Israel, Elgendy Ahmed, Karpelowsky Jonathan, Lobos Pablo, Wijnen Marc, Fuchs Jörg, Hayes Andrea, Gerstle Justin T. International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines. ecancer 2022 Feb 17; 16:1356 JIF: 3.00 
  • A history of paediatric surgery in Singapore. AS Jacobsen, AHP Loh, VT Joseph. Singapore Med J 2021; 62(1 Suppl): S61-S63 JIF: 1.858
  • Selective use of Peptide Receptor Radionuclide Therapy following comparative imaging of Ga-68 DOTATATE PET/CT against I-131 MIBG scintigraphy in a small cohort of adult neuroblastoma. ZX Koo, AK Tong, SY Soh, M Farid, A Loh, KS Loke. The Medical Journal of Malaysia. 2021 Jul 1; 76(4):573-577. JIF: 0.502
  • Association of anesthetic and surgical risk factors with outcomes of initial diagnostic biopsies in a current cohort of children with anterior mediastinal masses. HF Halepota, JSK Tan, SK Reddy, PH Tang, LY Ong, YT Lee, MY Chan, SY Soh, KTE Chang, ASB Ng, AHP Loh. World J Pediatr Surg 2021;4:e000303. JIF: 2.764
  • Integrated Genomic Profiling and Drug Screening of Patient-Derived Cultures Identifies Individualized Copy Number-Dependent Susceptibilities Involving PI3K Pathway and 17q Genes in Neuroblastoma. RLY Wong, MRE Wong, CH Kuick, SE Saffari, MK Wong, SH Tan, K Merchant, KTE Chang, M Thangavelu, G Periyasamy, ZX Chen, P Iyer, EEK Tan, SY Soh, NG Iyer, Q Fan, AHP Loh. Front Oncol. 2021 Oct 14;11:709525. JIF: 6.244
  • Postoperative Rather Than Preoperative Neutropenia Is Associated With Early Catheter-related Bloodstream Infections in Newly Diagnosed Pediatric Cancer Patients. WQ Cher, V Lee, R Wang, SM Cheah, YT Lee, SE Saffari, CB Tan, CY Chong, JCM Lam, AHP Loh. Pediatr Infect Dis J. 2021 Sep 28. JIF: 3.806
  • Gastrointestinal and Oncologic Outcomes of Pediatric Gastrointestinal Lymphoma Following Upfront Resection or Biopsy of Bowel Masses. MY Othman, HF Halepota, YL Linn, YT Lee, KTE Chang, SH Ahamed, JCM Lam, R Bhattacharyya, AM Tan, AHP Loh. Pediatric Surgery International. 2021 Aug;37(8):1049-1059. JIF: 1.827
  • Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting. KT Lee, HY Wong, Q Zeng, JL Lin, MS Cheng, CH Kuick, KTE Chang, AHP Loh, H Schwarz. Oncoimmunology. 2021 Feb 4;10(1):1877459 JIF: 7.19
  • Anaesthetic modality and post-surgical oncological outcomes for paediatric tumours: is there a link? Lee SY, Acharyya S, Tan AWL, Loh AHP. Singapore Med J Singapore Med J. 2021 Jan;62(1):20-28. JIF: 1.858
  • Laparoscopic Experience and Attitudes Towards a Low-Cost Laparoscopic System Among Surgeons in East, Central and Southern Africa. NE Farrow, SJ Commander, CR Reed, J Mueller, A Gupta. AHP Loh, J Sekabira, TN Fitzgerald. Surg Endosc 2020 Nov JIF: 4.595
  • Hepatitis B virus seropositivity is a poor prognostic factor of pediatric hepatocellular carcinoma: A population-based study in Hong Kong and Singapore. APY Liu, SY Soh, FWC Cheng, HH Pang, CW Luk, CH Li, KKH Ho, KWE Chan, A Chan, PHY Chung, MS Kimpo, HA Summaiyya, A Loh, AKS Chiang. Front Oncol. 2020 Nov 20;10:570479. JIF: 6.244
  • Massively parallel single-molecule telomere length measurement with digital real-time PCR. Luo Y, Viswanathan R, Hande MP, Loh AHP, Cheow LF. Sci Adv. 2020 Aug 21;6(34):eabb7944. JIF: 14.136
  • Pediatric Solid Tumor Care and Multidisciplinary Tumor Boards in Low- and Middle-Income Countries in Southeast Asia. Othman MY, Blair S, Nah SA, Ariffin H, Assanasen C, Soh SY, Jacobsen AS, Lam C, Loh AHP. JCO Glob Oncol. 2020 Aug;6:1328-1345.
  • Neuroblastoma patient-derived cultures are enriched for mesenchymal gene signature and reflect individual drug response. Hee E, Wong MK, Tan SH, Choo Z, Kuick CH, Ling S, Yong MH, Jain S, Lian DW, Ng EH, Yong YF, Ren MH, Sulaiman NS, Low SY, Chua YW, Syed MF, Lim TK, Soh SY, Iyer P, Seng MS, Lam JC, Tan EE, Chan MY, Tan AM, Chen Y, Chen Z, Chang KT, Loh AH. Cancer Science 2020; 111(10):3780-92. JIF: 6.716
  • Congenital mesoblastic nephroma is characterized by kinase mutations including EGFR internal tandem duplications, ETV6-NTRK3 fusion, and rare KLHL7-BRAF fusion. Zhao M, Yin M, Kuick CH, Chen H, Aw SJ, Merchant K, Ng EHQ, Gunaratne S, Loh AHP, Gu W, Tang H, Chang KTE. Histopathology 2020; 77(4):611-621. JIF: 5.087
  • Posterior retroperitoneoscopic adrenalectomy for pediatric adrenal tumors. Lee YT; Samsudin H; Ong CCP; Tang PH; Lim KBL; Loh AHP. Journal of pediatric surgery 2019; 54(11):2348-2352. JIF: 2.143
  • Evaluation of a Novel Bony Landmark-Based Method for Teaching Percutaneous Insertion of Subclavian Venous Catheters in Pediatric Patients. Lin ZJ; Lee YT; Chua JHY; Wang R; Lee V; Cheah SM; Saffari SE; Lam JCM; Loh AHP. World journal of surgery 2019; 43(8):2106-2113 JIF: 2.234
  • Retroperitoneal tumors and congenital variations in vascular anatomy of retroperitoneal great vessels. Tip SWM; Lee YT; Tang PH; Chang KTE; Soh SY; Tan AM; Loh AHP. Journal of pediatric surgery 2019; 54(10):2112-2116 JIF: 2.143
  • Clinical, pathological and loss of heterozygosity differences in Wilms tumors between Asian and non-Asian children. Loke BN; Wong MK; Tawng KD; Kuick CH; Jain S; Lian D; Wagner E; Zou Y; Ganesan V; Sim SW; Lee YT; Chin F; Chan MY; Tan AM; Teh BT; Soh SY; Chang KTE; Loh AHP. International journal of cancer 2019; 144(6):1234-1242. JIF: 5.145
  • Combinatorial screening using orthotopic patient derived xenograft-expanded early phase cultures of osteosarcoma identify novel therapeutic drug combinations. Loh AHP; Stewart E; Bradley CL; Chen X; Daryani V; Stewart CF; Calabrese C; Funk A; Miller G; Karlstrom A; Krafcik F; Goshorn DR; Vogel P; Bahrami A; Shelat A; Dyer MA. Cancer letters 2019; 442:262-270 JIF: 7.360
  • Mechanical versus Chemical Pleurodesis after Bullectomy for Primary Spontaneous Pneumothorax: A Systemic Review and Meta-Analysis. Sim SKR, Nah SA, Loh AHP, Ong LY, Chen Y. Eur J Pediatr Surg 2019. JIF: 1.919
  • Destined to Die: Apoptosis and Pediatric Cancers. Choo Z, Loh AHP, Chen ZX. Cancers (Basel) 2019; 11(11):1623-1623 JIF: 6.162
  • Clinical Relevance of Screening Checklists for Detecting Cancer Predisposition Syndromes in Asian Childhood Tumours. SH Chan, W Chew, ND Ishak, WK Lim, ST Li, SH Tan, JX Teo, T Shaw, K Chang, Y Chen, P Iyer, EEK Tan, MSF Seng, MY Chan, AM Tan, SYY Low, SY Soh, AHP Loh*, J Ngeow* (*co-corresponding author). NPJ Genomic Medicine 2018; 15(3):30-30 JIF: 3.467
  • Clinical management of pheochromocytoma and paraganglioma in Singapore: missed opportunities for genetic testing.Chew WHW, Courtney E, Lim KH, Li ST, Chen Y, Tan MH, Chung A, Khoo J, Loh A, Soh SY, Iyer P, Loh LM, Ngeow J.Mol Genet Genomic Med. 2017 Jul 20;5(5):602-607.
  • Clear cell sarcomas of the kidney are characterised by BCOR gene abnormalities, including exon 15 internal tandem duplications and BCOR-CCNB3 gene fusion.Wong MK, Ng CCY, Kuick CH, Aw SJ, Rajasegaran V, Lim JQ, Sudhanshi J, Loh E, Yin M, Ma J, Zhang Z, Iyer P, Loh AHP, Lian DWQ, Wang S, Goh SGH, Lim TH, Lim AST, Ng T, Goytain A, Loh AHL, Tan PH, Teh BT, Chang KTE. Histopathology. 2018 Jan;72(2):320-329. JIF 3.453
  • Management of a Kaposiform haemangioendothelioma of the kidney with Kasabach-Meritt phenomenon without chemotherapy. New MS, Ong MW, Lam JCM, Chang KTE, Fortier MV, Wijeweera O, Tan AM, Loh AHP. Pediatr Hematol Oncol J. 2016 Oct; 1(4):89-92.
  • Re: External validation of the Paediatric Risk of Malignancy Index. Loh AH*, Lee YT, Lam SL, Ong CL. BJOG. 2016 Jul;123(8):1399.
  • XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis. Choo Z, Koh RY, Wallis K, Koh TJ, Kuick CH, Sobrado V, Kenchappa RS, Loh AH, Soh SY, Schlisio S, Chang KT, Chen ZX. Oncotarget. 2016 Apr 15.
  • Initial diagnostic management of pediatric bone tumors. Interiano RB, Malkan AD, Loh AH, Hinkle N, Wahid FN, Bahrami A, Mao S, Wu J, Bishop MW, Neel MD, Gold RE, Rao BN, Davidoff AM, Fernandez-Pineda I.. J Pediatr Surg. Epub 2016 Mar 2
  • Thyroglossal duct cyst carcinoma: diagnostic and management considerations in a 15 year old with a large submental mass. Seow-En I, Loh AHP, Lian DWQ, Nah S. BMJ Case Rep. Epub 2015 Jul 6.
  • Systematic screening identifies dual PI3K and mTOR inhibition as a conserved therapeutic vulnerability in osteosarcoma. Gupte A, Baker W, Wan S, Stewart E, Loh A, Shelat A, Gould C, Chalk A, Taylor S, Lackovic K, Karlstrom A, Mutsaers A, Desai J, Madhamshettiwar P, Zannettino A, Burns C, Huang D, Dyer M, Simpson K, Walkley C. Clin Cancer Res. 2015 Jul 15;21(14):3216-29. Epub 2015 Apr 10.
  • Novel karyotypes and cyclin D1 immunoreactivity in clear cell sarcoma of the kidney. Aw SJ, Wang S, Loh AH, Kuick CH, Lian DW, Yong MH, Ling S, Peh GL, Soh SY, Loh AH, Tan PH, Chang KT. Pediatr Dev Pathol. 2015 Jul-Aug;18(4):297-304. Epub 2015 Mar 9.
  • Oncological Surgery in Children. In: Surgery: Core Principles & International Practice (Section 7, Chapter 5). JD Corson, RCN Williamson (eds). Loh AH, Davidoff AM. 2nd edition, Jaypee Medical Publishers, May 20 2015
  • Soft Tissue Sarcomas. In: Pediatric Surgery (Springer Atlas Series). P Puri, ME Hollwarth (ed). Loh AH, Rao BN. 2nd edition, Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2015
  • Central Venous Access Devices in Oncology Patients. In: The Baby Bear Book: A Practical Guide on Paediatrics. SY Soh, S Jamuar, J Puthucheary (eds). Soh SY, Loh A, Toh L, Pham TNA, Chong CY. 3rd edition, Red Cells Series, SingHealth Academy, 2015.
  • An Approach to Renal Masses in Pediatrics. Malkan A, Loh AH, Bahrami A, Navid F, Coleman J, Green D, Davidoff AM, Sandoval JA. Pediatrics. 2015 Jan;135(1):142-58. Epub 2014 Dec 1. JIF 5.47
  • Long-term Physiologic and Oncologic Outcomes of Inferior Vena Cava Thrombosis in Pediatric Malignant Abdominal Tumors. Loh A, Bishop M, Krasin M, Davidoff AM, Langham MR Jr. J Pediatr Surg. 2015 Apr;50(4):550-5. Epub 2014 Dec 2.
  • Safety and Diagnostic Accuracy of Tumor Biopsies in Children with Cancer. Interiano RB / Loh AH, Hinkle N, Wahid FN, Malkan A, Bahrami A, Jenkins JJ, Mao S, Wu J, Proctor K, Santana VM, Pappo AS, Gold RE, Davidoff AM. Cancer. 2015 Apr 1;121(7):1098-107. Epub 2014 Dec 18.
  • Influence of Bony Resection Margins and Surgicopathological Factors on Outcomes in Limb-Sparing Surgery for Extremity Osteosarcoma. Loh AH, Wu H, Bahrami A, Navid F, McCarville MB, Wang C, Wu J, Bishop MW, Daw NC, Neel MD, Rao BN. Pediatr Blood Cancer. 2014 Epub 2014 Nov 8.
  • The Role of Thoracoscopic Surgery in Pediatric Oncology. Malkan AD, Loh AH, Fernandez-Pineda I, Sandoval JA. J Laparoendosc Adv Surg Tech A. 2014 Nov;24(11):819-26. Epub 2014 Oct 7. JIF 1.335
  • Targeting the DNA Repair Pathway in Ewing Sarcoma. Stewart E, Goshorn R, Bradley C, Griffiths LM, Benavente C, Twarog N, Miller GM, Caufield W, Freeman BB, Bahrami A, Pappo A, Wu J, Loh A, Karlström Å, Calabrese C, Gordon B, Tsurkan L, Hatfield MJ, Potter PM, Snyder SE, Thiagarajan S, Shirinifard A, Sablauer A, Shelat AA, Dyer MA. Cell Reports. 2014 November 6;9(3):829-40. Epub 2014 Oct 23.
  • Minimally invasive surgery in the management of abdominal tumors in children. Malkam A, Loh AH, Sandoval JA. J Pediatr Surg. 2014 Jul;49(7):1171-1176. Epub 2014 May 22. JIF 1.311
  • Rhabdomyosarcoma. In: Encyclopedia of Pediatric Surgery (Volume 2), P Puri (ed). Loh AH, Rao BN. 1st edition, Springer-Verlag Berlin and Heidelberg GmbH & Co. K, Apr 30 2014.
  • Management of Local Recurrence of Pediatric Osteosarcoma Following Limb-Sparing Surgery. Loh AH, Navid F, Wang C, Bahrami A, Wu J, Neel MD, Rao BN. Ann Surg Oncol. 2014 Jun;21(6):1948-55. Epub 2014 Feb 21.
  • Diagnostic accuracy of pre-operative alpha-fetoprotein as an ovarian tumor marker in children and adolescents - not as good as we thought? Loh AH*, Gee KW, Chua JH. Pediatr Surg Int. 2013 Jul;29(7):709-13. Epub 2013 May 8.
  • Dissecting the PI3K Signaling Axis in Pediatric Solid Tumors: Novel Targets for Clinical Integration. Loh AH, Brennan RC, Lang W, Hickey RJ, Malkas LH, Sandoval JA. Front Oncol. 2013 Apr;23;3:93. doi:10.3389/fonc.2013.00093.
  • Pediatric risk of malignancy index for preoperative evaluation of childhood ovarian tumors. Loh AH*, Ong CL, Lam SL, Chua JH, Chui CH. Pediatr Surg Int. 2012 Mar;28(3):259-66. Epub 2011 Dec 8.
  • Diagnostic delay in pediatric solid tumors: A population based study on determinants and impact on outcomes. Pediatr Blood Cancer. Loh AH*, Aung L, Ha C, Tan AM, Quah TC, Chui CH. Pediatr Blood Cancer. 2012 Apr;58(4):561-5. Epub 2011 Nov 2.
  • Neonatal ovarian cysts: role of sonography in diagnosing torsion. Chinchure D, Ong CL, Loh AH, Rajadurai VS. Ann Acad Med Singapore. 2011 Jun;40(6):291-5.
  • Gene expression of TRK neurotrophin receptors in advanced neuroblastomas in Singapore--a pilot study. Fung W, Hasan MY, Loh AH, Chua JH, Hwee YM, Knight L, Sek HW, Yoke CM, Tew SW, Jacobsen AS, Hon CC. Pediatr Hematol Oncol. 2011 Oct;28(7):571-8. Epub 2011 Jul 5.
  • Delays in Diagnosis of Paediatric Tumours in Singapore. Loh AH, Ha C, Chua JHY, WT Seow, MY Chan, AM Tan, Chui CH. J Pediatr Hematol Oncol. 2009 Oct;31(10):734-8
  • Presentation and Progression of Benign Prostatic Hyperplasia: A Singapore Experience Profiling Differences in a Multi-Racial Study Cohort. Loh AH, Ng KK, Ng FC. Annals Acad Med Singapore 2009;38(5):451-6
  • The Diagnostic, Prognostic and Therapeutic Roles of Trk Neurotrophin Receptors (Trks) Expressions in Neuroblastoma. Fung WKY, Loh AH, Yong MY, Knight L, Hwang WS, Chan MY, Seow WT, Chui CH, Jacobsen AS. KK Hospital. Review 2008 Dec;11(2):71-74
  • Use of Multiplex RT-PCR Assay for Evaluating the Significance of Trk Neurotrophin Receptors Gene Expression In Children with Neuroblastoma in Singapore Between 2003-2007. Fung WKY, Loh AH, Yong MH, Knight L, Hwang WS, Chan MY, Soh SY, Tan AM, Seow WT, Chui CH, Jacobsen AS. KK Hospital Review 2008 Dec;11(2):68-70
  • Port-A-Cath Insertions in Acute Leukaemia: Does Thrombocytopaenia Affect Morbidity? Loh AH, Chui CH. J Pediatr Surg 2007 Jul;42(7):1180-4
  • Port-A-Cath Insertions in Acute Leukaemia and Childhood Malignancies. Loh AH, Chui CH. Asian J Surg 2007 Jul;30(3):193-9
  • Neonatal Intestinal Volvulus Due to A Persistent Right Vitelline Artery. Loh AH, Prasad ST, Chew SH, Jacobsen AS. Pediatr Surg Int. 2007 Apr;23(4):373-6
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Research Trials

  • Modelling, Analysis and Translational Therapeutics for Tumours of Childhood (MAT3CH)
  • Longitudinal Assessment of Biomarkers for Treatment-response Evaluation in Solid Tumours (LABTEST)

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