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Clin Assoc Prof Chong Chia Yin

Clin Assoc Prof Chong Chia Yin


Senior Consultant

KK Women's and Children's Hospital

Specialty: Paediatric Infectious Disease

Sub-specialties: Infectious Diseases

Clinical Appointments

  • Senior Consultant Infectious Disease Service KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Clinical Quality & Patient Safety, Division of Medicine KK Women's and Children's HospitalKK Women's and Children's Hospital



  • MBBS 1987
  • MMED Paediatrics (Singapore) 1992
  • MRCP (Paediatrics), United Kingdom, 1993
  • Fellowship in Paediatric Infectious Diseases, Boston Children’s Hospital, USA
  • ARiMI-Certified Enterprise Risk Manager 2016
  • Certified Professional in Healthcare Quality, Healthcare Quality Certification Commission

Professional Appointments and Committee Memberships

  • Adjunct Associate Professor in Pediatrics (Yong Loo Lin School of Medicine, National University of Singapore)
  • Adjunct Associate Professor, Duke-GMS
  • Clinical Teacher, Lee Kong Chian School of Medicine, Nanyang Technological University
  • Physician Faculty, Singhealth Paediatrics Residency programme
  • MOH Executive committee on Immunization from 2004, Chairman from 2010
  • MOH advisory committee on the clinical management of dengue from 2013
  • MOH advisory group of pre-pandemic influenza vaccines from 2013
  • MOH Expert committee on Bioterrorism Threats from 2016
  • Singapore Infectious Disease initiative executive research committee member from 2013
  • Hospital Infection Control Committee from 2003
  • Singhealth Infection Control Committee from 2013
  • Singapore Healthcare Improvement Network (SHINE) Hand Hygiene Workstream from 2015
  • KKH Patient Safety Council from 2016
  • KKH Quality Improvement network from 2017
  • KKH Medical BOard
  • Singhealth Environmental Hygiene workgroup 2016-2017
  • SAF Executive Committee for Immunization from 2013
  • 12th WPCCID, Singapore Organizing Committee, 2010
  • MOH National Pediatric Review Committee 2010
  • Specialist Training Committee for Pediatrics 2009-2011
  • AIDS Task Force, Singapore 1999-2006
  • Hand-Foot-Mouth Disease Task Force 2000 -2015
  • SMC committee fort the accreditation of House office training 2008-2011


  • Singhealth Residency Outstanding Faculty Award Academic year 2016-2017, August 2017
  • National Day Long Service Award 2016, August 2016
  • Top 10 abstracts Award at 7th International Congress of the Asia Pacific Society of Infection Control
    (APSIC 2015), March 2015
  • Singhealth Quality Service April 2011-March 2012 – Silver Award, 2012
  • Residency in SingHealth Excels (RISE) award certificate of appreciation for SHS residency program, 2012

Research Interests

  • Invasive Pneumococcal Disease
  • Entervirus Diseases
  • Meningitis
  • Tuberculosis
  • HIV
  • Vaccine Complications
  • Employee Health and Staff Vaccination


  • Risk factors of ICU or high dependency requirements amongst hospitalized pediatric pertussis cases: A 10 year retrospective series, Singapore. Chong CY, Yung CF, Tan NW, Acharyya S, Thoon KC. Vaccine. 2017 Oct 9. pii: S0264-410X(17)31353-1. doi: 10.1016/j.vaccine.2017.09.085.
  • Outbreak of Zika virus infection in Singapore: an epidemiological, entomological, virological, and clinical analysis. Singapore Zika Study Group. Lancet Infect Dis. 2017 Aug;17(8):813-821. doi: 10.1016/S1473-3099(17)30249-9. Epub 2017 May 17.
  • Invasive pneumococcal disease in Singapore children. Chong CY, Thoon KC, Mok YH, N. Tee. Vaccine May 2008 26: 3427-31
  • Characteristics of Zika Virus Disease in Children: Clinical, Hematological, and Virological Findings from an Outbreak in Singapore. JH Li, CY Chong, NWH Tan, CF Yung, NWS Tee,KC Thoon. Clin Infect Dis. 2017 May 15;64(10):1445-1448. doi: 10.1093/cid/cix137
  • Sensitive detection of Zika virus antigen in patients’ whole blood as an alternative diagnostic approach. FM Lum, C Lin, OY Susova, TH Teo, SW Fong, TZ Mak, Linda Kay Lee, Chia-Yin Chong, DCB Lye, RT.P. Lin, A Merits, YS Leo, L F.P. Ng. J Infect Dis. 2017 Jul 15;216(2):182-190. doi: 10.1093/infdis/jix276
  • *Prevention of human immunodeficiency virus (HIV) transmission from mother to child- A cohort study in Singapore. CY Chong, WYM Ng, YS Leo, SY Se-Thoe, AE Ling, KP Chan. Annals of Academy, Singapore, 2001; 30:387-92
  • Epidemic hand-foot and mouth disease caused by enterovirus 71, Singapore. KY Chan, KT Goh, CY Chong, ES Teo, G Lau, AE Ling. Emerging Infectious Diseases Jan 2003; 9: 78-85
  • *Lower respiratory tract infection in hospitalized children. CY Chong, WH Lim, JPL Tang, A Goh, L Ho, OM Chay. Respirology 2003; 8: 83-9.
  • *Treatment of urinary tract infection with gentamicin once or three times daily. CY Chong, ASL Tan, W Ng, A Tan-Kendrick, A. Balakrishnan, SM Chao. Acta Paediatrica Mar 2003; 92: 291-6.
  • *Hand, Foot and Mouth disease in Singapore: a comparison of fatal and non-fatal cases. CY Chong, KP Chan, VA Shah, WYM Ng, G Lau, TES Teo, SH Lai, AE Ling. Acta Paediatrica Jan 2003; 92: 1-8
  • Clinical characteristics of an outbreak of hand, foot and mouth disease in Singapore. VA Shah, CY Chong, KP Chan W Ng, AE Ling. Annals, Academy Med, Singapore May 2003; 32: 381-7.
  • *Varicella Screening and vaccination for health -care workers at KKH. Annals, Academy of Medicine March 2004; 33: 243-7. Chong CY
  • Book: A Guide on Infectious Disease of Public Health Importance in Singapore (6th Ed). Ministry of Health 2004; chapters 3, 10,17,20, 25, appendix 3.
  • Ecthyma gangrenosum: a manifestation of Psuedomonas sepsis in 3 paediatric patients. Sing Med J Dec 2006; 47: 1080-3. Chan YH, Chong CY, J Puthucheary, Loh TF.
  • Skin manifestations of Sternotrophomonas maltophilia infection- a case report and review article. Ann Acad Med Singapore 2006l Dec 35: 897-4. Teo WY, Chan MY, Lam CM, Chong CY
  • Epidemiology, clinical characteristics and antimicrobial resistance patterns of community-acquired pneumonia in 1702 hospitalized children in Singapore. Respirology 2007 March, 12: 254-61.Chiang WC, Teoh OH, Chong CY, A Goh, JP Tang, Chay OM.
  • Epidemiology pf invasive Hemophilus influenzae type b disease in Singapore children 1994-2003. Vaccine Aug 2007; 25: 6482-9. Thoon KC, Chong CY, Ng WY, Kilgore PE, Nyambat B
  • Vaccines in children. The Singapore Family Physician from College of Family Physician Singapore Vol 33(3) July-September 2007.
  • The Efficacy of Influenza vaccination in healthcare workers in a tropical setting: A prospective investigator blinded observational study. Ann Acad Med Sing 2008; 37: 465-9. Kheok SW, Chong CY, McCarthy G et al.
  • Surveillance of pneumococcal-associated disease among hospitalised children in Khanh Hoa Province, Vietnam. Anh DD, Kilgore PE, Slack MP, Nymbat B, Thoe le H, Yoshida LM, Nguyen HA, Nguyen CD, Chong CY, Nguyen D, Ariyoshi K, Clemens JD, Jodar L. Clin Infect Dis 2009, Mar 48 Suppl 2: S57-64.
  • Overview of the disease burden of invasive pneumococcal disease in Asia. ASAP working group. Vaccine 2009. Dec 9; 27 (52): 7282-91.
  • Influenza A /H1N1 (2009) infection in pregnancy- an Asian perspective. Lim ML, Chong CY, Tee WS, Lim WY, CHee JJ. BJOG 2010 Apr; 117 (5): 551-6. Epub 2010 feb 10.
  • Survey of healthcare workers’ attitudes, beliefs, and willingness to receive the 2009 pandemic influenza A (H1N1) vaccine and the impact of educational campaigns. Thoon KC, Chong CY. Ann Acad Med Singapore 2010 Apr 39 ( 4): 307-8
  • Pertussis- An underdiagnosed disease with high morbidity in Singapore children. A Goh, Chong CY, N Tee, Loo LH, Yeo JG, Chan YH. Vaccine 2011; 29: 2503-2507
  • Early impact of pneumococcal conjugate vaccine on invasive pneumococcal disease in Singapore children, 2005 through 2010. KC Thoon, CY Chong, NWS Tee. Int J Infect Dis 2012;16:e209-215
  • Immunogenicity and safety of recombinant tetravalent dengue vaccine (CYD-TDV) in individuals aged 2-45 y: Phase II randomized controlled trial in Singapore. Hum Vaccin Immunother. 2012 Sep;8(9):1259-71. doi: 10.4161/hv.21224. Epub 2012 Aug 16. Sin Leo Y, Wilder-Smith A, Archuleta S, Shek L, Chong CY, et al
  • EY Ang, JY Soh, WK Liew, KW Chan, KC Thoon, CY Chong, YL Lau, BW Lee. Reliability of Acute Illness Dihydrorhodamine-123 Testing for Chronic Granulomatous Disease. Clinical Lab 2013; 59: 203-206
  • Teacher led school-based surveillance can allow accurate tracking of emerging infectious diseases – evidence from serial cross-sectional surveys of febrile respiratory illness during the H1N1 2009 influenza pandemic in Singapore. SE Soh, AR Cook, MIC Chen, VJ Lee, JL Cutter, VTK Chow, NWS Tee, RTP Lin, WY Lim, IG Barr, C Lin, S Vaidya, MC Phoon, LW Ang, SK Sethi, CY Chong, LG Goh, DLM Goh, PA Tambyah, KC Thoon, YS Leo, SM Saw. BMC Infectious Diseases 2012;12:336
  • Risk Factors for Complicated Influenza A (H1N1) 2009 Disease in Children. Chong CY, Tan N, Thoon KC, Menon A, Tee NWS. Annals Acad Singapore 2013; 42: 232-6.
  • Impact of an antimicrobial stewardship program on the use of carbapenems in a tertiary women's and children's hospital, Singapore. Seah XF, Ong YL, Tan SW, Krishnaswamy G, Chong CY, Tan NW, Thoon KC.Pharmacotherapy. 2014 Nov;34(11):1141-50. doi: 10.1002/phar.1490. Epub 2014 Oct 4.
  • Judicious Utilization of Healthcare Resources - Reducing Un-indicated Pediatric Anaerobic Blood Cultures in a Pediatric Hospital.Ong I, P Agarwal, P Raut, Chong CY. Journal for Healthcare Quality 2015; 37: 1-7.
  • Granulomatous cervico-facial lymphadenitis in children - 9 year study in Singapore, Thoon KC, K Subramania, Chong CY, Chang KTE, Tee NWS. Singapore Medical Journal 2014 Aug; 55(8):427-31.
  • Risk Factors for Severe Adenovirus Infection in Children during an Outbreak in Singapore. Rajkumar V, Chiang CS, Low JM, Cui L, Lin RT, Tee NW, Maiwald M, Chong CY, Thoon KC, Tan NW. Ann Acad Med Singapore. 2015 Feb;44(2):50-9.
  • Active surveillance of adverse events following childhood immunization in Singapore. KC Thoon, SBL Soh, WK Liew, A Gunachandran, NWTH Tan, CY Chong, CF Yung, Vaccine. 2014 Sep 3;32(39):5000-5. doi: 10.1016/j.vaccine.2014.07.020. Epub 2014 Jul 18.
  • Investigations into an outbreak of suppurative lymphadenitis with BCG vaccine SSI in Singapore. SBL Soh, PY Han, KT Tan, CF Yung, WK Liew, NWH Tan, CY Chong, KC Thoon Vaccine. 2014 Oct 7;32(44):5809-15. doi: 10.1016/j.vaccine.2014.08.032. Epub 2014 Aug 27.
  • A randomised trial to evaluate the immunogenicity, reactogenicity, and safety of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) co-administered with routine childhood vaccines in Singapore and Malaysia. Fong Seng Lim, Mia Tuang Koh, Kah Kee Tan, Poh Chong Chan, Chia Yin Chong, Yeo Wee Shung Yehudi, Yee Leong Teoh, Fakrudeen Shafi, Marjan Hezareh, Kristien Swinnen and Dorota Borys . BMC Infectious Diseases 2014, 14:530 doi:10.1186/1471-2334-14-530
  • Near disappearance of childhood invasive Haemophilus influenzae type b disease in Singapore.
    Thoon KC, Tee NW, Chew L, Chong CY. Vaccine. 2014 Oct 7;32(44):5862-5. doi: 10.1016/ j.vaccine.2014.08.046. Epub 2014 Aug 27.
  • Melioidosis in children: a retrospective study. Foong YW, Tan NW, Chong CY, Thoon KC, Tee NW, Koh MJ. Int J Dermatol. 2015 Mar 13. doi: 10.1111/ijd.12837. [Epub ahead of print]
  • Neurology of the H1N1 pandemic in Singapore: a nationwide case series of children and adults. Prerna A, Lim JY, Tan NW, Isa MS, Oh HM, Yassin N, Low CY, Chan DW, Chong CY, Leo YS, Chow AL, Tambyah PA, Tan K. J Neurovirol. 2015 Apr 28.
  • Temporal trend in the incidence of pertussis and exposures among healthcare workers: Descriptive report from a tertiary care hospital for children in Singapore. C.Y. Chong, N.W.H. Tan, H. Yunos, S.H. Lim, S. Acharyya, K.C. Thoon. J Hosp Infection Oct 2015; 91 (2015) 371e378
  • A 15-year retrospective analysis of prognostic factors in childhood bacterial meningitis. LYJ Wee, R Reinaldo Tanugroho, KC Thoon, CY Chong, CT Choong,S Krishnamoorthy, M Maiwald, NWS Tee, NWH Tan. Acta Paediatrica 2015; DOI:10.1111/apa.13228
  • A case of cutaneous penicilliosis in a child with acute myeloid leukaemia.SG Krishnan, NWS Tee, AL Tan, AM Tan,MJA Koh, CY Chong, KC Thoon , NWH Tan. JMM Case Reports (2015) DOI 10.1099/jmmcr.0.000098

Research Trials

  • NMRC grant: Virological, molecular epidemiological surveillance and biomarker discovery of human enteroviruses in children with hand, foot and mouth disease in Singapore, 2012- ongoing
  • Phase III, multicenter double blind randomized study to assess antibody persistence after completion of 3 dose primary vaccine course with PCV10 in study 10PN-PD-DiT-048 in Singapore when given as a booster dose at 18-21 months of age, 2010-2011
  • Prospective, Open label nonrandomized multicenter study to investigate the safety and tolerability of voriconazole as primary therapy for treatment of invasive aspergillosis and moulds grant, 2009-2013
  • Phase II double blind randomized study to evaluate the immunogenicity and safety of GSK combined MMR-varicella vaccine ( Priorix-Tetra TM), 2009-2010
  • Phase III multicenter double blind randomized study to assess non-inferiority of a commercial lot of GSK 10-valent pneumcoccal conjugate (10PN-PD-DIT) vaccine compared to a clinical phase II vaccine lot.2009-2011