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Adj Assoc Prof Chong Chia Yin

Adj Assoc Prof Chong Chia Yin

MBBS, MMed, MRCP, FAMS, FRCPCH, ARiMI-CERM, CPHQ

Senior Consultant

KK Women's and Children's Hospital

Specialty: Paediatric Infectious Disease

Clinical Interest: Infectious Diseases

Clinical Appointments

  • Director, Clinical Quality & Patient Safety, Division of Medicine KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Senior Consultant Infectious Disease Service KK Women's and Children's HospitalKK Women's and Children's Hospital

Academic Appointments

  • Adjunct Associate Professor in Pediatrics - Yong Loo Lin School of Medicine, National University of Singapore
  • Adjunct Associate Professor, Duke-GMS
  • Clinical teacher, Kee Kong Chian School of Medicine, Nanyang Technological University
  • Physician faculty, Singhealth Paediatrics Residency programme

Profile

Education

  • MBBS 1987
  • MMED Paediatrics (Singapore) 1992
  • MRCP (Paediatrics), United Kingdom, 1993
  • Fellowship in Paediatric Infectious Diseases, Boston Children’s Hospital, USA
  • ARiMI-Certified Enterprise Risk Manager 2016
  • Certified Professional in Healthcare Quality, Healthcare Quality Certification Commission

Professional Appointments and Committee Memberships

  • MOH Executive committee on Immunization from 2004, Chairman from 2010
  • MOH advisory committee on the clinical management of dengue from 2013
  • MOH advisory group of pre-pandemic influenza vaccines from 2013
  • MOH Expert committee on Bioterrorism Threats from 2016
  • Singapore Infectious Disease initiative executive research committee member from 2013
  • Hospital Infection Control Committee from 2003
  • SingHealth Infection Control Committee from 2013
  • Singapore Healthcare Improvement Network (SHINE) Hand Hygiene Workstream from 2015
  • KKH Patient Safety Council from 2016
  • KKH Quality Improvement network from 2017
  • KKH Medical BOard
Rest :
  • SingHealth Environmental Hygiene workgroup 2016-2017
  • SAF Executive Committee for Immunization from 2013
  • 12th WPCCID, Singapore Organizing Committee, 2010
  • MOH National Pediatric Review Committee 2010
  • Specialist Training Committee for Pediatrics 2009-2011
  • AIDS Task Force, Singapore 1999-2006
  • Hand-Foot-Mouth Disease Task Force 2000-2015
  • SMC committee fort the accreditation of House office training 2008-2011

Awards

  • SingHealth Residency Outstanding Faculty Award Academic year 2016-2017, August 2017
  • National Day Long Service Award 2016, August 2016
  • Top 10 abstracts Award at 7th International Congress of the Asia Pacific Society of Infection Control
    (APSIC 2015), March 2015
  • SingHealth Quality Service April 2011-March 2012 – Silver Award, 2012
  • Residency in SingHealth Excels (RISE) award certificate of appreciation for SHS residency program, 2012

Research Interests

Publications

  • Immunogenicity and safety of Sinovac-CoronaVac booster vaccinations in 12–17- year-olds with clinically significant reactions from Pfizer-BNT162b2 vaccination Chong CY, Kam KQ, Zhang J, Bertoletti A, Hariharaputran S, Sultana R, Piragasam R, Mah YY, Tan CW, Wang L,Yung CF. Vaccine Apr 2024; 42: 2951-54.
  • Combating a resurgence of poliomyelitis through public health surveillance and vaccination. Chong CY, Kam KQ, Yung CF. Ann Acad Med Singap 2023 Jan; 52: 17-26.
  • *Effectiveness of maternal pertussis vaccination in Singapore: a test-negative case-control study. Chong CY, Tan NWH, Yung CF, Li J, Kam KQ, Nadua K, Maiwald M, Sultana R, Thoon KC. Vaccine 2022 Nov 2; 40: 6570-6574.
  • BNT162b2 vaccine protection against Omicron (BA.4/BA.5/XBB) in 5 to 17 year olds and impact of previous infection variant and vaccination sequence: population based cohort study. CF Yung, D Pang, KQ Kam, DC Lye, B Ong, CY Chong, KB Tan. Lancet Child Adol 2023 July, 7 (7): 463-470
  • Effectiveness of monovalent mRNA vaccines against Omicron XBB in Singaporean children under 5 years. Wee ILE, Tang N, Pang D, Chiew C, Yung CF, Chong CY, Lee V, Ong B, Lye DC, Tan KB. JAMA Pediatrics 2023 Dec: 177 )12): 1324-1331.
  • mRNA SARS-CoV-2 vaccination before vs during pregnancy and infant protection. Orlanda Goh, M.B, Deanette Pang, Janice Tan, David Lye, Chia Yin Chong, Benjamin Ong, Kelvin Bryan Tan, Chee Fu Yung. JAMA Network Open 2023 Nov1; 6(11): e2342475.
  • BNT162b2 vaccine induced variant-specific immunity, safety and risk of Omicron breakthrough infection in children 5 to 11 years: a cohort study. Yung CF, Le Bert N, Kam KQ, Saffari SE, Tan CW, Mah YY, Zhang J, Yeoh ZY, Zhu F, Hariharaputran S, Chong CY et a. Sci Rep 2023 Oct13; 13 (1): 17337.
  • Remdesivir therapy for severe pediatric COVID-19 in Singapore: A single-centre retrospective observational cohort study. Seah VXF, Ong RYL, Kam KQ, Thoon KC, Tan NWH, Li J, Nadua KD, Chong CY Yung CF. Health Sc Rep Dec 2023; 6: e1698.
  • Long COVID prevalence, risk factors and impact of vaccination in the paediatric population: A survey study in Singapore. Li J, Nadua K, Chong CY, Yung CF. Ann Acad Singap 2023 Oct; 52:522-532.
  • T-cell hybrid immunity against SARS-Cov-2 in children: a longitudinal study. Qui M, Hariharaputran S, Hang SK, Zhang J, Tan CW, Chong CY et al. EBioMedicine 2024 June;105: 105203.
  • Multisystem inflammatory syndrome in children in Singapore. Nadua K, Chong CY, Kam KQ, Choo JTL, Lam JCM, Li J, Tan NWH, Yung CF, Chan BS, The KL, Das L, Arkachaisri T, Thoon KC. Annals Acad Med Nov 2022; 51: 669-676.
  • Clinical characteristics of macrolide-resistant Mycoplasma pneumonia infections among hospitalised children in Singapore. Li J, Maiwald M, Loo LH, Soong HY, Octavia S, Thoon KC, Chong CY. Ann Acad Med Singap Nov 2022; 51: 653-656.
  • A cohort study of COVID-19 infection in pediatric oncology patients plus the utility and safety of remdesivir treatment. Ong RYL, Seah VXF, Chong CY, Thoon KC, Tan NWH, Li J, Nadua KD, Soh SY, Seng MS, Pahm TNA, Yung CF, Kam KQ. Acta Oncol 2023 Jan; 20: 1-5
  • Effectiveness of primary series and booster vaccination against SARS-COV-2 infection and hospitalisation among adolescents aged 12-17 years in Singapore: a national cohort study. Chiew CJ, Premikha M, Chong CY, Wei WE, Ong B, Lye DC, Heng D, Lee VJ, Tan KB. Lancet Infect Dis Sep 2022; 28: S1473-3099 (22) 00573-4.
  • Paediatric actinomycosis: A 16-year, single-institution retrospective review of cases. Chew SJ, Low KBB, Chong CY, Maiwald M, Thoon KC, Ong RYL, Yung CF, Li J, Nadua KD, Kam KQ, Tan HKK, Lian DWQ, Tan LYR, Tan NWH. Journal of Paediatrics and Child Health (2023) doi:10.1111/jpc.16400
  • Clinical Profile of Children with Parechovirus Meningitis in Singapore. Jessica Tan HY, Choong CT, Tee NWS, Chong CY, Thoon KC, Maiwald M, Lee EYX, Tan MSS, Tan NWH. J Neurovirol 2022 Feb; 28: 46-51 
  • Implementation of Universal Newborn Screening for Severe Combined Immunodeficiency in Singapore while continuing routine Bacille-Calmette-Guerin (BCG) vaccination given at birth. Chan SB, Zhong Y, Lim SCJ, Poh S, The KL, Soh JY, Chong CY, Thoon KC, Seng M, Tan ES, Arkachaisri T, Liew WK. Front Immuno 2022 Jan; 12: 794221
  • Serotype distribution and incidence of invasive early onset and late onset group B streptococcal disease amongst infants in Singapore. Kam KQ, Thoon KC, Tee WSN, Ang MLT, Tan NWH, Yeo KT, Li J, Chong CY. BMC Infect Dis 2021 Dec; 21: 1221.
  • Pediatric Kawasaki disease trends prior to and during COVID-19 outbreak in Singapore. Chong CY, Tan NWH, Yung CF, Nadua KD, Kam KQ, Li JH, Thoon KC. J Pediatr Infect Dis Society Aug 2021 12: piabo47. Doi:10.1093/jpids/piab047.
  • A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19. Yeo JG, Leong JY, Tay SH, Nadua KD,Anderson DE, Lim AJM, Ng XW,Poh SL, Guo D, Yaung KN, Kumar P,Wasser M, Hazirah SN, Sutamam N,Chua CJH, Qui M, Foo R,Gamage AM, Yeo KT, Ramakrishna L,Arkachaisri T, Young BE, Lye DC,Wang L-F, Chong CY, Tan NWH, Li J,Kam K-Q, Ginhoux F, Thoon KC,Chan JKY, Yung CF and Albani S(2021)Front. Immunol. 12:674279.doi: 10.3389/fimmu.2021.674279
  • Patient, staff empowerment and hand hygiene bundle improved and sustained hand hygiene in hospital wards. CY Chong, MA Catahan, SH Lim, T Jais, G Kaur, SQ Yin, D de Korne, KC Thoon, KC Ng. J Paediatr Child Health Sep 2021; 57 (9): 1460-66.
  • Novel Coronavirus 2019 Transmission Risk in Educational Settings. Yung CF, Kam KQ, Nadua KD, Chong CY, et al. Clin Infect Dis 2021 Mar 15; 72 (6): 1055-1058.
  • Characterization of oral virome and microbiome revealed distinctive microbiome disruptions in paediatric patients with hand, foot and mouth disease. Ho SX, Min N, Wong EPY, Chong CY, Chu JJH. NPJ Biofilms Microbiomes 2021 Feb; 19: 7: 19.
  • An Epidemiological Surveillance of Hand Foot and Mouth Disease in Paediatric Patients and in Community: A Singapore Retrospective Cohort Study, 2013-2018. Ju JHJ, N Min, Ong YHB, Han AX, Ho SX, Wong EPY, Ban KHK, Mauer-Stroh S, Chong CY, Chu JJH. PLOS Neglected Tropical Diseases 2021 Feb; 15: e0008885
  • SARS-CoV-2 Viral RNA Load Dynamics in the Nasopharynx of Infected Children. Kam KQ, Thoon KC, Maiwald M, Chong CY, et al. Epidemio Infect 2021 Jan 11; 149:e18. Doi: 10.1017/S095026882100008X.
  • Household Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 from Adults to Children. Yung CF, Kam KQ, Chong CY, et al. J Pediatr. 2020 Jul 4;225:249–51
  • Clinical Utility of Buccal Swabs for Severe Acute Respiratory Syndrome Coronavirus 2 Detection in Coronavirus Disease 2019-Infected Children. Kam KQ, Yung CF, Maiwald M, Chong CY, et al. J Pediatric Infect Dis Soc. 2020 Jul 13;9(3):370-372
  • Chong CY, Kam KQ, Li JH, et al. Saliva is not a useful diagnostic specimen in children with Coronavirus Disease 2019, Clin Infect Dis 2020 Sep 14: ciaa1376 https://doi.org/10.1093/cid/ciaa1376
  • A Well Infant With Coronavirus Disease 2019 With High Viral Load. Kam KQ, Yung CF, Lin C, Lin RTP, Mak TM, Maiwald M, Li JH, Chong CY et al. Clin Infect Dis 2020Jul28; 71 (15): 847-849.
  • The burden and clinical manifestation of hospitalized influenza among different pediatric age groups in the tropics. Chong CY, Yung CF, Gan C, Thio ST, Tan NWH, Tee NWS, Lin C, Lin RTP, Thoon KC. Influenza Other Respir Viruses. 2020 Jan; 14:46-54. doi: 10.1111/irv.12692
  • Disseminated BCG infections and primary immunodeficiency disorders in Singapore: a single centre 15 year retrospective review. Ong RYL, Chan SB, Chew SJ, Liew WK, Thoon KC, Chong CY et al. Int J Infect Dis Aug 2020; 97: 117-125.
  • Taurolidine-citrate lock solution for the prevention of central line-associated bloodstream infection in paediatric haematology-oncology and gastrointestinal failure patients with high baseline central line-associated bloodstream infection rates. Chong CY, Ong RY, et al. J Paediatr Child Health 2019 May 30; doi:1-.1111/jpc.14506
  • ZIKV-specific NS1 epitopes as serological markers of acute Zika virus infection. Kam YW, Leite JA, Amrun SN, Lum FM, Yee WX, Bakar FA, Eng KE, Lye DC, Leo YS, Chong CY et al, J Infect Dis 2019 Mar 7. Pii:jiz092. Doi: 10.1093/infdis/jiz092
  • Temporal relationship between occurrences of hand, foot and mouth disease, respiratory virus detection and febrile seizures in children in tropical Singapore: a time-series analysis. Chen Y, Chong CY, Cook AR, Sim NTW, Horby P, La HH. Epidemio Infect 2018 Sep 13: 1-6.
  • Paediatric tuberculosis in Singapore: a retrospective review. Loh SW, Thoon KC, Tan NWH, Li J, Chong CY. BMJ Paediatr Open 2018 sep 11: 2 (1): e000308
  • Feasibility Of A Real-Time Hand Hygiene Notification Machine Learning System In Outpatient Clinics. Roel Geilleit, Zhi Qian Hen, Chia Yin Chong, Ai Poh Loh, Nguk Lan Pang, Gregory M.Peterson, Kee Chong Ng, Anita Huis, Dirk F. de Korne. J Hosp Infection 2018 Apr 9. pii: S0195-6701(18)30216-0
  • Circulating Salivary miRNA hsa-miR-221 as Clinically Validated Diagnostic Marker for Hand, Foot, and Mouth Disease in Pediatric Patients.Nyo Min, Previtha Dawn Sakthi Vale, Anng Anng Wong, Natalie Woon Hui Tan, Chia Yin Chong, Chih-Jung Chen, Robert Y.L. Wang, Justin Jang Hann Chu. EBioMedicine. 2018 May;31:299-306.
  • Kikuchi-Fujimoto disease in children. Shoba N Selvanathan, Sharline Suhumaran, Vinay K Sahu, Chia Yin Chong, Natalie Woon Hui Tan, Koh Cheng Thoon. J Paed Child Health 2020 Mar; 56 (3): 389-393. doi: 10.1111/jpc.14628.
  • Risk factors of ICU or high dependency requirements amongst hospitalized pediatric pertussis cases: A 10-year retrospective series, Singapore. Chong CY, Yung CF, Tan NW, Acharyya S, Thoon KC. Vaccine. 2017 Oct 9. pii: S0264-410X(17)31353-1. doi: 10.1016/j.vaccine.2017.09.085.
  • Outbreak of Zika virus infection in Singapore: an epidemiological, entomological, virological, and clinical analysis. Singapore Zika Study Group. Lancet Infect Dis. 2017 Aug;17(8):813-821. doi: 10.1016/S1473-3099(17)30249-9. Epub 2017 May 17.
  • Invasive pneumococcal disease in Singapore children. Chong CY, Thoon KC, Mok YH, N. Tee. Vaccine May 2008 26: 3427-31
  • Characteristics of Zika Virus Disease in Children: Clinical, Hematological, and Virological Findings from an Outbreak in Singapore. JH Li, CY Chong, NWH Tan, CF Yung, NWS Tee,KC Thoon. Clin Infect Dis. 2017 May 15;64(10):1445-1448. doi: 10.1093/cid/cix137
  • Sensitive detection of Zika virus antigen in patients’ whole blood as an alternative diagnostic approach. FM Lum, C Lin, OY Susova, TH Teo, SW Fong, TZ Mak, Linda Kay Lee, Chia-Yin Chong, DCB Lye, RT.P. Lin, A Merits, YS Leo, L F.P. Ng. J Infect Dis. 2017 Jul 15;216(2):182-190. doi: 10.1093/infdis/jix276

    Rest:

  • *Prevention of human immunodeficiency virus (HIV) transmission from mother to child- A cohort study in Singapore. CY Chong, WYM Ng, YS Leo, SY Se-Thoe, AE Ling, KP Chan. Annals of Academy, Singapore, 2001; 30:387-92
  • Epidemic hand-foot and mouth disease caused by enterovirus 71, Singapore. KY Chan, KT Goh, CY Chong, ES Teo, G Lau, AE Ling. Emerging Infectious Diseases Jan 2003; 9: 78-85
  • *Lower respiratory tract infection in hospitalized children. CY Chong, WH Lim, JPL Tang, A Goh, L Ho, OM Chay. Respirology 2003; 8: 83-9.
  • *Treatment of urinary tract infection with gentamicin once or three times daily. CY Chong, ASL Tan, W Ng, A Tan-Kendrick, A. Balakrishnan, SM Chao. Acta Paediatrica Mar 2003; 92: 291-6.
  • *Hand, Foot and Mouth disease in Singapore: a comparison of fatal and non-fatal cases. CY Chong, KP Chan, VA Shah, WYM Ng, G Lau, TES Teo, SH Lai, AE Ling. Acta Paediatrica Jan 2003; 92: 1-8
  • Clinical characteristics of an outbreak of hand, foot and mouth disease in Singapore. VA Shah, CY Chong, KP Chan W Ng, AE Ling. Annals, Academy Med, Singapore May 2003; 32: 381-7.
  • Epidemiology, clinical characteristics and antimicrobial resistance patterns of community-acquired pneumonia in 1702 hospitalized children in Singapore. Respirology 2007 March, 12: 254-61.Chiang WC, Teoh OH, Chong CY, A Goh, JP Tang, Chay OM.
  • Epidemiology pf invasive Hemophilus influenzae type b disease in Singapore children 1994-2003. Vaccine Aug 2007; 25: 6482-9. Thoon KC, Chong CY, Ng WY, Kilgore PE, Nyambat B
  • The Efficacy of Influenza vaccination in healthcare workers in a tropical setting: A prospective investigator blinded observational study. Ann Acad Med Sing 2008; 37: 465-9. Kheok SW, Chong CY, McCarthy G et al.
  • Surveillance of pneumococcal-associated disease among hospitalised children in Khanh Hoa Province, Vietnam. Anh DD, Kilgore PE, Slack MP, Nymbat B, Thoe le H, Yoshida LM, Nguyen HA, Nguyen CD, Chong CY, Nguyen D, Ariyoshi K, Clemens JD, Jodar L. Clin Infect Dis 2009, Mar 48 Suppl 2: S57-64.
  • Overview of the disease burden of invasive pneumococcal disease in Asia. ASAP working group. Vaccine 2009. Dec 9; 27 (52): 7282-91.
  • Survey of healthcare workers’ attitudes, beliefs, and willingness to receive the 2009 pandemic influenza A (H1N1) vaccine and the impact of educational campaigns. Thoon KC, Chong CY. Ann Acad Med Singapore 2010 Apr 39 ( 4): 307-8
  • Early impact of pneumococcal conjugate vaccine on invasive pneumococcal disease in Singapore children, 2005 through 2010. KC Thoon, CY Chong, NWS Tee. Int J Infect Dis 2012;16:e209-215
  • Immunogenicity and safety of recombinant tetravalent dengue vaccine (CYD-TDV) in individuals aged 2-45 y: Phase II randomized controlled trial in Singapore. Hum Vaccin Immunother. 2012 Sep;8(9):1259-71. doi: 10.4161/hv.21224. Epub 2012 Aug 16. Sin Leo Y, Wilder-Smith A, Archuleta S, Shek L, Chong CY, et al
  • Teacher led school-based surveillance can allow accurate tracking of emerging infectious diseases – evidence from serial cross-sectional surveys of febrile respiratory illness during the H1N1 2009 influenza pandemic in Singapore. SE Soh, AR Cook, MIC Chen, VJ Lee, JL Cutter, VTK Chow, NWS Tee, RTP Lin, WY Lim, IG Barr, C Lin, S Vaidya, MC Phoon, LW Ang, SK Sethi, CY Chong, LG Goh, DLM Goh, PA Tambyah, KC Thoon, YS Leo, SM Saw. BMC Infectious Diseases 2012;12:336
  • Risk Factors for Complicated Influenza A (H1N1) 2009 Disease in Children. Chong CY, Tan N, Thoon KC, Menon A, Tee NWS. Annals Acad Singapore 2013; 42: 232-6.
  • Impact of an antimicrobial stewardship program on the use of carbapenems in a tertiary women's and children's hospital, Singapore. Seah XF, Ong YL, Tan SW, Krishnaswamy G, Chong CY, Tan NW, Thoon KC.Pharmacotherapy. 2014 Nov;34(11):1141-50. doi: 10.1002/phar.1490. Epub 2014 Oct 4.
  • Judicious Utilization of Healthcare Resources - Reducing Un-indicated Pediatric Anaerobic Blood Cultures in a Pediatric Hospital.Ong I, P Agarwal, P Raut, Chong CY. Journal for Healthcare Quality 2015; 37: 1-7.
  • Granulomatous cervico-facial lymphadenitis in children - 9 year study in Singapore, Thoon KC, K Subramania, Chong CY, Chang KTE, Tee NWS. Singapore Medical Journal 2014 Aug; 55(8):427-31.
  • Risk Factors for Severe Adenovirus Infection in Children during an Outbreak in Singapore. Rajkumar V, Chiang CS, Low JM, Cui L, Lin RT, Tee NW, Maiwald M, Chong CY, Thoon KC, Tan NW. Ann Acad Med Singapore. 2015 Feb;44(2):50-9.
  • Active surveillance of adverse events following childhood immunization in Singapore. KC Thoon, SBL Soh, WK Liew, A Gunachandran, NWTH Tan, CY Chong, CF Yung, Vaccine. 2014 Sep 3;32(39):5000-5. doi: 10.1016/j.vaccine.2014.07.020. Epub 2014 Jul 18.
  • Investigations into an outbreak of suppurative lymphadenitis with BCG vaccine SSI in Singapore. SBL Soh, PY Han, KT Tan, CF Yung, WK Liew, NWH Tan, CY Chong, KC Thoon Vaccine. 2014 Oct 7;32(44):5809-15. doi: 10.1016/j.vaccine.2014.08.032. Epub 2014 Aug 27.
  • A randomised trial to evaluate the immunogenicity, reactogenicity, and safety of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) co-administered with routine childhood vaccines in Singapore and Malaysia. Fong Seng Lim, Mia Tuang Koh, Kah Kee Tan, Poh Chong Chan, Chia Yin Chong, Yeo Wee Shung Yehudi, Yee Leong Teoh, Fakrudeen Shafi, Marjan Hezareh, Kristien Swinnen and Dorota Borys . BMC Infectious Diseases 2014, 14:530 doi:10.1186/1471-2334-14-530
  • Near disappearance of childhood invasive Haemophilus influenzae type b disease in Singapore.
    Thoon KC, Tee NW, Chew L, Chong CY. Vaccine. 2014 Oct 7;32(44):5862-5. doi: 10.1016/ j.vaccine.2014.08.046. Epub 2014 Aug 27.
  • Melioidosis in children: a retrospective study. Foong YW, Tan NW, Chong CY, Thoon KC, Tee NW, Koh MJ. Int J Dermatol. 2015 Mar 13. doi: 10.1111/ijd.12837. [Epub ahead of print]
  • Neurology of the H1N1 pandemic in Singapore: a nationwide case series of children and adults. Prerna A, Lim JY, Tan NW, Isa MS, Oh HM, Yassin N, Low CY, Chan DW, Chong CY, Leo YS, Chow AL, Tambyah PA, Tan K. J Neurovirol. 2015 Apr 28.
  • Temporal trend in the incidence of pertussis and exposures among healthcare workers: Descriptive report from a tertiary care hospital for children in Singapore. C.Y. Chong, N.W.H. Tan, H. Yunos, S.H. Lim, S. Acharyya, K.C. Thoon. J Hosp Infection Oct 2015; 91 (2015) 371e378
  • A 15-year retrospective analysis of prognostic factors in childhood bacterial meningitis. LYJ Wee, R Reinaldo Tanugroho, KC Thoon, CY Chong, CT Choong,S Krishnamoorthy, M Maiwald, NWS Tee, NWH Tan. Acta Paediatrica 2015; DOI:10.1111/apa.13228

Research Trials

  • NMRC grant: Virological, molecular epidemiological surveillance and biomarker discovery of human enteroviruses in children with hand, foot and mouth disease in Singapore, 2012-ongoing
  • Phase III, multicenter double blind randomized study to assess antibody persistence after completion of 3 dose primary vaccine course with PCV10 in study 10PN-PD-DiT-048 in Singapore when given as a booster dose at 18-21 months of age, 2010-2011
  • Prospective, Open label nonrandomized multicenter study to investigate the safety and tolerability of voriconazole as primary therapy for treatment of invasive aspergillosis and moulds grant, 2009-2011
  • Prospective, Open label nonrandomized multicenter study to investigate the safety and tolerability of voriconazole as primary therapy for treatment of invasive aspergillosis and moulds grant, 2009-2013
  • Phase II double blind randomized study to evaluate the immunogenicity and safety of GSK combined MMR-varicella vaccine ( Priorix-Tetra TM), 2009-2010
  • Phase III multicenter double blind randomized study to assess non-inferiority of a commercial lot of GSK 10-valent pneumcoccal conjugate (10PN-PD-DIT) vaccine compared to a clinical phase II vaccine lot.2009-2011

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