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Assoc Prof Lee Jan Hau

Assoc Prof Lee Jan Hau


Senior Consultant

KK Women's and Children's Hospital

Specialty: Children's Intensive Care

Clinical Interest: Extracorporeal Membrane Oxygenation (ECMO), Continuous Renal Replacement Therapy, Paediatric Medical Intensive Care, Paediatric Surgical Intensive Care, Paediatric Cardiac Intensive Care, CHETS, Paediatric Home Ventilation

Clinical Appointments

  • Senior Consultant Children's Intensive Care Unit KK Women's and Children's HospitalKK Women's and Children's Hospital


Dr Lee Jan Hau is currently working as a senior consultant in the pediatric critical care medicine at the Children's Intensive Care Unit, KK Women's and Children's Hospital, Singapore. He completed by basic and advanced pediatric training in Singapore. He is admitted into the membership of the Royal College of Paediatrics and Child Health, United Kingdom in 2005 and obtained his pediatric specialist accreditation in Singapore in 2009. He did his advanced pediatric critical care medicine fellowship at Duke Children's Hospital, Durham from 2011 - 2012. He is active in pediatric critical care research and his research interests include pediatric critical care epidemiology, acute respiratory distress syndrome and critical care nutrition.


  • Masters of Clinical Investigation 2014
  • Specialist Accreditation in Paediatric Medicine 2009
  • Membership of the Royal College of Paediatrics & Child 2005
  • MBBS, National University of Singapore 2001

Professional Appointments and Committee Memberships

  • Senior Consultant, Department of Paediatric Subspecialties, Children’s Intensive Care
  • Adjunct Assistant Professor, Duke-NUS Medical School April 2013 - current
  • Senior Clinical Lecturer, Yong Loo Lin School of Medicine, National University of Singapore January 2013 - current 


  • Singhealth Publish! Award 2016
  • Dean’s Award for Teaching 2015
  • Young Investigator Award 2015
  • Singhealth Publish! Award 2014
  • Healthcare Manpower Development Plan (HMDP) in Pediatric Critical Care 2011
  • KID (Khoo’s Investigator Development) Programme October 2009 – November 2010
  • ExxonMobil-NUS Clinician Scientist Fellowship November 2007 -October 2008

Research Interests

  • Pediatric critical care epidemiology
  • Pediatric acute respiratory distress syndrome
  • Pediatric critical care nutrition


  • Gradidge EA, Bakar A, Tellez D, Ruppe M, Tallent S, Bird G, Lavin N, Lee A, Adu-Darko M, Bain J, Biagas K, Branca A, Breuer RK, Brown C 3rd, Bysani GK, Cheifitz IM, Emeriaud G, Gangadharan S, Giuliano JS Jr, Howell JD, Krawiec C, Lee JH, Li S, Meyer K, Miksa M, Napolitano N, Nett S, Nuthall G, Orioles A, Owen EB, Parker MM, Parsons S, Polikoff LA, Rehder K, Saito O, Sanders RC Jr, Shenoi AN, Simon DW, Skippen PW, Tarquinio K, Thompson A, Toedt-Pingel I, Vanderford P, Walson K, Nadkarni V, Nishisaki A; National Emergency Airway Registry for Children (NEAR4KIDS) and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI). Effect of Location on Tracheal Intubation Safety in Cardiac Disease-Are Cardiac ICUs Safer? Pediatr Crit Care Med. 2017 Dec 15 [Epub ahead of print]
  • Kojima T, Laverriere EK, Owen EB, Harwayne-Gidansky I, Shenoi AN, Napolitano N, Rehder KJ, Adu-Darko MA, Nett ST, Spear D, Meyer K, Giuliano JS Jr, Tarquinio KM, Sanders RC Jr, Lee JH, Simon DW, Vanderford PA, Lee AY, Brown CA 3rd, Skippen PW, Breuer RK, Toedt-Pingel I, Parsons SJ, Gradidge EA, Glater LB, Culver K, Li S, Polikoff LA, Howell JD, Nuthall G, Bysani GK, Graciano AL, Emeriaud G, Saito O, Orioles A, Walson K, Jung P, Al-Subu AM, Ikeyama T, Shetty R, Yoder KM, Nadkarni VM, Nishisaki A; National Emergency Airway Registry for Children (NEAR4KIDS) Collaborators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI). Clinical Impact of External Laryngeal Manipulation During Laryngoscopy on Tracheal Intubation Success in Critically Ill Children. Pediatr Crit Care Med. 2017 Nov 14. [Epub ahead of print]
  • Leow EH, Chan YH, Ng YH, Lim KBJ, Masakazu N, Lee JH. Prevention of acute kidney injury in children undergoing cardiac surgery: A narrative review. World Journal for Pediatric and Congenital Heart Surgery 2017 [In press]
  • Wong JJ, Quek BH, Lee JH. Establishing the Entity of Neonatal Acute Respiratory Distress Syndrome. Journal of Thoracic Disease 2017 Nov;9(11):4244-4247
  • Lim KBJ, Mok YH, Loh YJ, Tan TH, Lee JH. The impact of time to rate control of junctional ectopic tachycardia after congenital heart surgery. World Journal for Pediatric and Congenital Heart Surgery 2017 Nov;8(6):685-690
  • Wong JJ, Phuc PH, Phumeetham S, Ong JSM, Chor YK, Qian S, Samransamruajkit R, Anantasit N, Gan CS, Feng X, Sultana R, Loh TF, Lee JH, for the Pediatric Acute & Critical care Medicine Asian Network (PACCMAN). Risk Stratification in Pediatric Acute Respiratory Distress Syndrome: A Multicenter Study. Critical Care Medicine 2017 (In Press)
  • Leow EH, Soh SY, Tan AM, Mok YH, Chan MY, Lee JH. Critically Ill Children with Hemophagocytic Lymphohistiocytosis: A Case Series of 14 Patients. Journal of Pediatric Hematology and Oncology 2017 Aug;39(6):e303-e306
  • Ong CS, Lee JH. Protein provision in the critically ill child: is less more? Lancet Respiratory Medicine 2017 Jun;5(6):458-459
  • Grunwell JR, Kamat PP, Miksa M, Krishna A, Walson K, Simon D, Krawiec C, Breuer R, Lee JH, Gradidge E, Tarquinio K, Shenoi A, Shults J, Nadkarni V, Nishisaki A; National Emergency Airway Registry for Children (NEAR4KIDS) and the Pediatric Acute Lung Injury and Sepsis (PALISI) Network. Trend and Outcomes of Video Laryngoscope Use Across PICUs. Pediatr Crit Care Med. 2017 Aug;18(8):741-749.
  • Lee JH, Greenberg R, Quek BH, Smith PB, Laughon MM, Clark RH, Hornik CP. Association between early echocardiography, patent ductus arteriosus therapy, and outcomes in very low birth weight infants. Cardiology in the Young 2017 Nov;27(9):1732-1739
  • Chong SL, Lee JH. The end of the road for early tracheal intubation in cardiac arrest? Journal of Thoracic Disease April 2017;9(4)976-978
  • Loi M, Wang J, Ong CS, Lee JH. Nutritional support of critically ill adults and children with acute respiratory distress syndrome: a clinical review. Clinical Nutrition ESPEN 2017 (In press)
  • Wong JJ, Jit M, Sultana R, Mok YH, Yeo JG, Koh JWJC, Loh TF, Lee JH. Mortality in Pediatric Acute Respiratory Distress Syndrome: A Systematic Review and Meta-analysis. Journal of Intensive Care Medicine 2017 [Epub ahead of print]
  • Koh JWJC, Wong JJ, Wong P, Sultana R, Mok YH, Lee JH. Risk factors of poor outcome in children with severe pneumonia. Pediatric Pulmonology 2017 Aug;52(8):1076-1084
  • Chong SL, Teoh OH, Nadkarni N, Yeo JG, Lwin Z, Ong G, Lee JH. The Modified Respiratory Index Score (RIS) Guides Resource Allocation in Acute Bronchiolitis. Pediatric Pulmonology 2017 Jul;52(7):954-961
  • Sng QW, Kirk AHP, Buang SNH, Lee JH. Ethnic and Cultural Differences Impact on Parental Satisfaction in the Pediatric Intensive Care Unit. Pediatric Critical Care Medicine 2017 Apr;18(4):e167-e175.
  • Fu Y, Chong SL, Lee JH, Liu C, Fu S, Loh TF, Ng KC, Xu F. The Impact of Early Hyperglycaemia In Children With Traumatic Brain Injury. Brain Injury 2017;31(3):396-400
  • Ong C, Lee JH, Leow M, Puthucheary Z. Skeletal muscle ultrasonography in nutrition and functional outcome assessment of critically ill children: experience and insights from pediatric disease and adult critical care studies. Journal of Parenteral and Enteral Nutrition 2016 (In press)
  • Parker MM, Nuthall G, Brown C, Biagas K, Napolitano N, Polikoff LA, Simon D, Miksa M, Gradidge E, Lee JH, Krishna AS, Tellez D, Bird GL, Rehder KJ, Turner DA, Adu-Darko M, Nett ST, Derbyshire AT, Meyer K, Giuliano J Jr, Owen EB, Sullivan JE, Tarquinio K, Kamat P, Sanders RC Jr, Pinto M, Bysani GK, Emeriaud G, Nagai Y, McCarthy MA, Walson KH, Vanderford P, Lee A, Bain J, Skippen P, Breuer R, Tallent S, Nadkarni V, Nishisaki A, for the National Emergency Airway Registry for Children (NEAR4KIDS) Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Relationship between Adverse Tracheal Intubation Associated Events and Pediatric ICU Outcomes. Pediatric Critical Care Medicine 2017 Apr;18(4):310-318
  • Lim J, Lee JH, Chefeitz IM. Special considerations for the management of pediatric acute respiratory distress syndrome. Expert Review of Respiratory Medicine 2016 Oct;10(10):1133-45
  • Ahmad Hatib NA, Lee JH, Loh LE, A Menon, Loh TF, Tan TH. Accidental intra-arterial infusion of amiodarone in a pediatric patient with atrial ectopic tachycardia. Critical Care Medicine 2016 Oct;44(10):e1013-4
  • Mok YH, Loke A, Loh TF, Lee JH. Characteristics and risk factors for mortality in paediatric in-hospital cardiac events in Singapore: A retrospective single centre experience. Annals of Academy of Medicine 2016 Dec;45(12):534-541
  • Lee JH, Turner DA, Kamat P, Nett S, Shults J, Nadkarni VM, Nishisaki A. The number of tracheal intubation attempts matters! A prospective multi-institutional pediatric observational study. BMC Pediatrics 2016; 16:58 (DOI: 10.1186/s12887-016-0593-y)
  • Sanders RC Jr, Nett ST, Davis KF, Parker MM, Bysani GK, Adu-Darko M, Bird GL, Cheifetz IM, Derbyshire AT, Emeriaud G, Giuliano JS Jr, Graciano AL, Hagiwara Y, Hefley G, Ikeyama T, Jarvis JD, Kamat P, Krishna AS, Lee A, Lee JH, Li S, Meyer K, Montgomery VL, Nagai Y, Pinto M, Rehder KJ, Saito O, Shenoi AN, Taekema HC, Tarquinio KM, Thompson AE, Turner DA, Nadkarni VM, Nishisaki A, for the National Emergency Airway Registry for Children (NEAR4KIDS) Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Family Presence During Pediatric Tracheal Intubations. JAMA Pediatrics 2016;170(3):e154627
  • Wong JJ, Han WM, Sultana R, Loh TF, Lee JH. Nutrition Delivery Impacts Outcomes in Pediatric Acute Respiratory Distress Syndrome. Journal of Parenteral and Enteral Nutrition 2017 Aug;41(6):1007-1013
  • Lee JH, Smith PB, Quek BH, Laughon MM, Clark RH, Hornik CP. Risk Factors and In-Hospital Outcomes Following Tracheostomy in Infants. The Journal of Pediatrics 2016 Mar 1. pii: S0022-3476(16)00182-7.
  • Ong C, Lee JH, Leow M, Puthucheary Z. Functional outcomes and physical impairments in pediatric critical care survivors: a scoping review. Pediatric Critical Care Medicine 2016 May;17(5):e247-59
  • Lim J, Lee JH, Mok YH, Chen CK, Loh YJ. Intramyocardial hematoma after Ebstein anomaly repair: A case of unexpected diagnosis and its management. World Journal for Pediatric and Congenital Heart Surgery 2016 Apr 20 [Epub ahead of print]
  • Mok YH, Lee JH, Cheifetz IM. Neonatal extracorporeal membrane oxygenation: Update on management strategies and long-term outcomes. Advances in Neonatal Care 2016 Feb; 16(1):26-36
  • Chew SP, Chong SL, Barbier S, Matthew A, Lee JH, Chan YH. Risk factors for severe hand foot mouth disease in Singapore: a case control study. BMC Infectious Diseases 2015 Oct 31;15(1):486
  • Lee JH, Gentile MA. High flow nasal cannula—coming to a hypoxic patient near you! Journal of Thoracic Diseases 2015;7(8):E234-E236
  • Lee JH, Hornik CP, Testoni D, Laughon MM, Cotton CM, Maldonado RS, Belcastro MR, Clark RH, Smith PB. Insulin, Hyperglycemia, and Severe Retinopathy of Prematurity in Extremely-low-birth-weight Infants. American Journal of Perinatology 2016 Mar;33(4):393-400
  • Lee JH, Rogers E, Chor YK, Samransamruajkit R, Koh PL, Miqdady M, Al-Mehaidib AI, Pudjiadi A, Singhi S, Mehta NM. Consensus on optimal nutrition therapy in the paediatric critical care environment in Asia-Pacific and the Middle East. Asia Pacific Journal of Clinical Nutrition (In press)
  • Shan Chew EC, Baier N, Lee JH. Do β-Blockers Decrease the Hypermetabolic State in Critically Ill Children With Severe Burns? Hospital Pediatrics. 2015 Aug;5(8):446-51
  • Wong JJM, Cheifetz IM, Ong C, Masakazu N, Lee JH. Nutrition Support of Children Undergoing Congenital Heart Surgeries: A Narrative Review. World Journal for Pediatric and Congenital Heart Surgery July 2015 6: 443-454 
  • Chong SL, Harjanto S, Testoni D, Ng ZM, Low CYD, Lee KP, Lee JH. Early Hyperglycemia in Pediatric Traumatic Brain Injury Predicts for Mortality, Prolonged Duration of Mechanical Ventilation, and Intensive Care Stay. International Journal of Endocrinology vol. 2015, Article ID 719476, doi:10.1155/2015/719476
  • Wong JJM, Han WM, Ong C, Mehta NM, Lee JH. Survey of Contemporary Feeding Practices in Critically Ill Children in Asia-Pacific and the Middle East. Asia Pacific Journal of Clinical Nutrition 2016 Mar;25(1):118-25
  • Chong SL, Lee KP, Lee JH, Ong G, Ong M. Pediatric Head Injury – A pain for the emergency physician? Clinical and Experimental Emergency Medicine 2015; 2(1):1-8
  • Lim J, Lee JH, Mok YH, Chan YH. Successful use of extracorporeal membrane oxygenation in a neonate with arterial pH less than 6.6. World Journal for Pediatric and Congenital Heart Surgery July 2015 6: 466-469
  • Tan WW, Chan DWS, Lee JH, Thomas T, Menon AP, Chan YH. Use of Magnesium Sulfate Infusion for the Management of Febrile Illness-Related Epilepsy Syndrome: A Case Series. Child Neurology Open January - March 2015 2: 2329048X14550067, doi:10.1177/2329048X14550067 
  • Kirk AHP, Ng BSP, Lee AN, Ang B, Lee JH. Perception Of Pediatric Critical Care Nurses On The Initiation Of A Nursing-Led Feeding Protocol. The Journal of Nursing Research 2015 Dec;23(4):308-12.
  • Mok YH, Lee JH, Rehder KJ, Turner DA. Adjunctive treatments in pediatric acute respiratory distress syndrome. Expert Rev Respir Med. 2014 Dec;8(6):703-16.
  • Poh YN, Poh PF, Buang SNH, Lee JH. Sedation Guidelines, Protocols and Algorithms in Pediatric Intensive Care Units: A Systematic Review. Pediatric Critical Care Medicine 2014 Nov;15(9):885-92
  • Wong JJM, Loh TF, Testoni D, Yeo JG, Mok YH, Lee JH. Epidemiology of Pediatric Acute Respiratory Distress Syndrome in Singapore: Risk Factors and Predictive Respiratory Indices for Mortality. Frontiers in Pediatrics 2014 Jul 25;2:78
  • Lee JH, Markert ML, Hornik CP, McCarthy EA, Gupton SE, Cheifetz IM, Turner DA. Clinical course and outcome predictors of critically ill infants with complete DiGeorge anomaly following thymus transplantation. Pediatric Critical Care Medicine 2014 Sep;15(7):e321-6.
  • Wong JJM, Lee JH, Turner DA, Rehder KA. A Review of the Use of Adjunctive Therapies in Severe Acute Asthma Exacerbation in Critically Ill Children. Expert Review of Respiratory Medicine 2014 Aug;8(4):423-41
  • Ong C, Han WM, Wong JJ, Lee JH. Nutrition biomarkers and clinical outcomes in critically ill children: A critical appraisal of the literature. Clinical Nutrition 2014 Apr;33(2):191-197
  • Wong JJ, Ong C, Han WM, Lee JH. Protocol Driven Enteral Nutrition in Critically Ill Children: A Systematic Review. Journal of Parenteral and Enteral Nutrition 2014;38(1):29-39
  • Ng ZM, Kavalloor NV, Lee JH. Should critically ill children with acute respiratory failure be treated with surfactant? Archives of Disease in Childhood 2013;98(7):558-61
  • Lee JH, Chan YH, Lai OF, Puthucheary J. Vasopressin and copeptin levels in children with sepsis and septic shock. Intensive Care Medicine 2013;39(4):747-753
  • Lee JH, Rehder KJ, Williford L, Cheifetz IM, Turner DA. Use of high flow nasal cannula in critically ill infants, children, and adults: A critical review of the literature. Intensive Care Medicine 2013;39(2):247-257
  • Lee JH, Hornik CP, Benjamin D Jr, Herring AH, Clark RH, Cohen-Wolkoweiz, Smith PB. Risk factors for invasive candidiasis in infants > 1500 g birth weight. Pediatric Infectious Disease Journal 2013;32(3):222-226
  • Lee JH, Loh TF. Efficacy of methylprednisolone in children with severe community acquired pneumonia. Pediatric Pulmonology 2013 Jul;48(7):731-2
  • Ting TW, Lee JH. Acute pancreatitis after propofol infusion in a teenage patient. Anaesthesia and Intensive Care 2012;40(3):561-562
  • Chong KW, Lee JH, Choong CT, Chan DWS, Fortier MV, Chan MY. Hemophagocytic Lymphohistiocytosis With Isolated Central Nervous System Reactivation and Optic Nerve Involvement. Journal of Child Neurology 2012; 27(10):1336-1339
  • Lim G, Lee JH. N-acetylcysteine in Children with Dengue-associated Liver Failure: A Case Report. Journal of Tropical Pediatrics 2012; 58(5): 409-413
  • Lee JH, Puthucheary J. Transport of Critically Ill Neonates with Cardiac Conditions. Air Medical Journal. 2010; 29(6):320-322
  • Lee JH, Loh TF. Continuous Hydrocortisone Infusion in Severe Paediatric Community-Acquired Pneumonia (CAP). Pediatrics International 2010;52(3):e125-e127

Research Trials