Prof Leung Wing Hang

Professor Leung is the Director of the Children's Blood and Cancer Centre and a Senior Consultant at KK Women's and Children's Hospital, part of SingHealth. He also serves as a Professor at Duke-NUS Medical School.

Previously, Professor Leung was a faculty member at Johns Hopkins University, and he held the position of Chair of Bone Marrow Transplantation and Cellular Therapy at St. Jude Children's Research Hospital. He also served as the Chair of the Department of Paediatrics at the University of Hong Kong.

He was honored with the title of Distinguished Professor and Chair of the SingHealth Duke-NUS Tan Cheng Lim – CCF Professorship in Paediatric Oncology. 

Throughout his career, Professor Leung has held several significant appointments, including Lead for SingHealth Transplant Research, Director of the Paediatric Bone Marrow Transplantation and Cellular Therapy Centre, and Director of Research at the SingHealth Duke-NUS Transplant Centre.

His research interests focus on the biology of human natural killer cells and T-memory cells, with a particular emphasis on their clinical applications in the treatment of cancer, blood disorders, immune system conditions, and infectious diseases.

• PhD 1998
• MBBS 1988

• Director, KKH Children's Blood and Cancer Centre
• Senior Consultant, Paediatric Haematology/Oncology Service, Department of Paediatric Subspecialties
• Director, Paediatric Bone Marrow Transplant & Cell Therapy Centre
• Professor, Duke-NUS Graduate School of Medicine 

ORCID: https://orcid.org/0000-0002-2996-7229

• Generation of CCR4/CD7 Bispecific CAR-T Cells Resistant to Fratricide and Exhaustion. Li S, Li Y, Rashid A, Tan HK, Chan S, Hui MY, Chan WYK, Lam KS, Liu Y, Tu W, Leung W. Adv Sci. 2026;13(35):e21443. JIF: 14.1
• Bicistronic CD19/CD22 CAR T-Cell Therapy in Pediatric B-Cell Acute Lymphoblastic Leukemia: A Nonrandomized Clinical Trial. Wan X, Tang Y, Cai J, Song L, Wang T, Li W, Yang L, Wang X, Luo C, Zhu H, An K, Su M, Zhang J, Yang J, Shi W, Fei C, Shen W, Jia R, Yang X, Tang J, Wu J, Gu J, Mo J, Huang J, Li Y, Zhou G, Ding L, Liang J, Wang J, Zhou Z, Wang X, Cao Q, Zhang J, Ren H, Qian J, Xiao P, He H, Jiang H, Hu S, Wang N, Zhu Y, Tang J, Gu L, Yang J, Cheng C, Chen J, Kuai W, Lu X, Shao J, Xie Z, Lu J, Leung W (as co-last author)*, Li B, Pui CH. JAMA Oncol. 2026; e263460. JIF:23.9
• A Phase I/II Trial of Anti-CD22/CD19 CAR-T Cell Therapy, CART2219.1, in Adult and Pediatric Relapsed/Refractory B-ALL. Seng MS, Guo Z, Ng KS, Soh SY, Inng Lim FW, Koh LP, Hwang WY, Ho AY, Linn YC, Chan EHL, Poon MLM, Tan LK, Koh MB, Ko TK, Yu J, Ng KP, Soh TG, Chan JY, Yeong JPS, Orentas RJ, Leung W. Blood Cancer Discov. 2026;2643-3230. JIF: 12.2
• Engineering fratricide-resistant CCR4/CD7 CAR T cells with enhanced safety and persistence for T cell malignancies. Li S, Tu W, Leung W. Mol Ther Oncol. 2026;20;34(2):201193. JIF: 8.5
• Chimeric antigen receptor-based cellular therapy for T-cell malignancies. Li S, Li Y, Hui MY, Rashid A, Tan HK, Chan S, Chan WYK, Lam KS, Tu W, Leung W. Crit Rev Oncol Hematol. 2026;217:105044. JIF: 6.2
• HLA vaccine effect in double cord blood transplant: a Chinese cohort. Wong CH, Chan WYK, Lee PPW, Cheuk DKL, Leung W. Blood Adv. 2025;9(20):5378-5379. JIF: 7.7
• Optimization of hypo-alloimmunogenic multispecific CAR-T and SARS-CoV-2-specific T cells for off-the-shelf adoptive cell therapy. Ng KP, Seng MS, Leung W. Mol Ther Methods Clin Dev. 2025;33(2):101462. JIF: 5.0
• The central role of natural killer cells in mediating acute myocarditis after mRNA COVID-19 vaccination. Tsang HW, Kwan MYW, Chua GT, Tsao SSL, Wong JSC, Tung KTS, Chan GCF, To KKW, Wong ICK, Leung W (as co-corresponding author)*, Ip P. Med. 2024;5(4):335-347.e3. JIF: 13.3
• Coadministration of CD19- and CD22-Directed Chimeric Antigen Receptor T-Cell Therapy in Childhood B-Cell Acute Lymphoblastic Leukemia: A Single-Arm, Multicenter, Phase II Trial. Wang T, Tang Y, Cai J, Wan X, Hu S, Lu X, Xie Z, Qiao X, Jiang H, Shao J, Yang F, Ren H, Cao Q, Qian J, Zhang J, An K, Wang J, Luo C, Liang H, Miao Y, Ma Y, Wang X, Ding L, Song L, He H, Shi W, Xiao P, Yang X, Yang J, Li W, Zhu Y, Wang N, Gu L, Chen Q, Tang J, Yang JJ, Cheng C, Leung W (as co-last author)*, Chen J, Lu J, Li B, Pui CH. J Clin Oncol. 2023;41(9):1670-1683. JIF: 46.2