Clin Assoc Prof Joyce Lam Ching Mei

MBBS, MMed (Paeds), MRCPCH (UK), FRCPA, FAMS

Senior Consultant

KK Women's and Children's Hospital

Specialty: Paediatric Haematology Oncology, Pathology ＆ Laboratory Medicine, Haematology

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About

Education and Training

Professional Appointments and Committee Memberships

Awards

Research Interests

Research Trials

Publications

Conditions Treated By This Doctor

Cancer (Child) Children Cancer Clotting and Bleeding Disorder Diagnostic Haematology Haemophilia in Children Paediatric Cytopaenias Thalassaemia Childhood Illness

Clinical Appointments

Senior Consultant

Haematology Oncology Service

Head of Service, Haematology Laboratory and Blood Bank

Department of Pathology and Laboratory Medicine

Senior Consultant

SingHealth Duke-NUS Blood Cancer Centre

About

Dr Joyce Lam Ching Mei is a Senior Consultant Haematologist and Head of the Haematology Laboratory and Blood Bank at KK Women’s and Children’s Hospital. She has expertise in diagnostic haematology, cytopaenias, bleeding and clotting disorders in children and general paediatric oncology. Her research interests include outcome-based assessments in haemophilia, long-term clnical outcomes in thalassaemia and anticoagulation strategies in extracorporeal membrane oxygenation. She is the Primary Investigator for a number of clinical trials in paediatric haemophilia and anticoagulation. She is also actively involved in undergraduate and postgraduate medical education.

Education and Training

FRCPA 2013
MMed (Paeds) 2004
MRCPCH 2004
MBBS 2000

Professional Appointments and Committee Memberships

Senior Clinical Lecturer, NUS Yong Loo Lin School of Medicine
Adjunct Assistant Professor, Duke-NUS Medical School
Clinical Teacher, Lee Kong Chian Medical School
Senior Consultant, Paediatric Haematology/Oncology Service, Department of Paediatric Subspecialties
Head, Haematology Laboratory and Blood Bank Service, Department of Pathology and Laboratory Medicine
Fellow, Academy of Medicine, Singapore
Ex-Co Member, Asia-Pacific Haemophilia Working Group
Ex-Co Member, Singapore Society of Haematology
Member, Asia-Pacific Society of Thrombosis and Haemostasis
Member, International Society of Thrombosis and Haemostasis
Member, World Federation of Haemophilia
Member, Paediatric Oncology Group Singapore

Awards

Singapore Health Quality Service Award, Silver (2018)
Best Poster Prize (Clinical Research Category), 9th KKH Annual Scientific Meeting (2017)
Yong Loo Lin School of Medicine Deans Award for Teaching Excellence (2016)
Singapore Health Quality Service Award, Silver (2014)
Service from the Heart Award (2013)
Long Service Award (2012)
Human Manpower Development Plan (HMDP) Award from Ministry of Health for 1-year fellowship in Clinical and Laboratory Haematology (2010)
RCPA QAP Prize for Best Poster Presentation, RCPA Pathology Update (2010)
Merit Award in Free Paper Competition, 2nd KKH Annual Scientific Meeting (2006)

Research Interests

Neurocognitive and social outcomes from acute lymphoblastic leukaemia (ALL) treatments
Epidemiology of bleeding disorders in children
Pharmacokinetic studies of aprepitant in paediatric and adolescent cancer patients
Cross-sectional study on the clinical and social outcomes of transfusion dependent Thalassaemia patients in Singapore

Research Trials

PROTECT VIII - A Phase II / III Multicentre, Partially Randomised, Open Label Trial Investigating Safety and Efficacy of On-Demand and Prophylactic Treatment with BAY94-9027 in Severe Haemophilia A – Site PI
PROPEL - Phase 3, Prospective, Randomized, Multi-center Clinical Study Comparing the Safety and efficacy of BAX 855 following PK-guided Prophylaxis Targeting two different FVIII Trough Levels in Subjects with Severe Hemophilia A – Site PI
Phase 3, prospective, multi-center, open label study to investigate safety,immunogenicity and hemostatic efficacy of PEGylated Factor VIII (BAX 855) in previously untreated patients (PUPs) < 6 years with severe hemophilia A (FVIII < 1%) – Site PI
A Phase 3, open-label, randomized, multi-center, controlled trial to evaluate the pharmacokinetics and pharmacodynamics of edoxaban and to compare the efficacy and safety of edoxaban with standard of care anticoagulant therapy in pediatric subjects from birth to less than 18 years of age with confirmed venous thromboembolism (VTE) – Site PI
EINSTEIN Junior - Multicenter, open-label, active-controlled, randomized study to evaluate the efficacy and safety of an age-and body weight-adjusted rivaroxaban regimen compared to standard of care in children with acute venous thromboembolism – Site PI

Publications

PRINCIPLES OF HAEMOPHILIA CARE: THE ASIA-PACIFIC PERSPECTIVE. Dunkley S, Lam JCM, John MJ, Wong RSM, Tran H, Yang R, Nair SC, Shima M, Street A, Srivastava A. for the Asia-Pacific Haemophilia Working Group (APHWG). Haemophilia 2018; DOI:10.1111/hae.13425
ANTICOAGULATION IN EXTRACORPOREAL MEMBRANE OXYGENATION. Judith Ju-Ming Wong, Joyce Ching Mei Lam, Yee Hui Mok, Jan Hau Lee. Journal of Emergency and Critical Care Medicine. Feb 2018; DOI: 10.21037/jeccm.2018.01.12
A RARE CASE OF ANTENATAL HEMORRHAGIC STROKE AND RECURRENT PURPURA FULMINANS IN A PRETERM NEWBORN. Ang IWL, Chan DKL, Lam JCM, Shah VA. NeoReviews Feb 2018; 19(2) e104-e108; DOI: 10.1542/neo.19-2-e104
WORKING TOGETHER ON TRANSFUSION AUDITS TO IMPROVE CLINICAL PRACTICE. Zhong X, Heng, ML, Lam JCM. ISBT Science Series 2018, DOI:10.1111/voxs.12407
THE BOY WITH THE RUDDY FACE: AN APPROACH TO POLYCYTHAEMIA PRESENTING IN CHILDHOOD – Lam JCM, Campbell S, Barnes C. Journal of Paediatrics and Child Health December 2017, DOI:10.1111/jpc.13820
LEUKAEMIA CUTIS OF THE SCALP - Rui K, Mei Yoke C, Yee L, Lam JCM. Archives of Disease in Childhood 2017, DOI:10.1136/archdischild-2017-313284
EPISODIC REPLACEMENT OF CLOTTING FACTOR CONCENTRATES DOES NOT PREVENT BLEEDING OR MUSCULOSKELETAL DAMAGE – THE MUSFIH STUDY - P. Poonnoose, JDA Carneiro, AL Cruickshank, M El Ekiaby, RP. Perez Bianco, MC Ozelo, N De Bosch, M. Baghaipour, SL L Tien, A Chuansumrit, EA D’amico, A Van Zyl, A Sabour, M Candela, JBS Ricciardi, A Ruiz-S Aez, R. Ravanbod, JCM Lam, S Jaovisidha, ML Kavitha, S Gibikote, N Shyamkumar, A. Srivastava. Haemophilia 2017; DOI: 10.1111/hae.13242
MANAGEMENT OF A KAPOSIFORM HAEMANGIOENDOTHELIOMA OF THE KIDNEY WITH KASABACH-MERITT PHENOMENON WITHOUT CHEMOTHERAPY - Nwe MS, Ong MW, Lam JCM, Chang KT-E, Fortier MV, Wijeweera O, Tan AM, Loh AHP. Pediatric Hematology Oncology Journal 2017, doi:10.1016/j.phoj.2017.03.001
CAUSATIVE PATHOGENS OF FEBRILE NEUTROPAENIA IN CHILDREN TREATED FOR ACUTE LYMPHOBLASTIC LEUKAEMIA - Joyce CM Lam, Jie Yang Chai, Yi Ling Wong, Natalie WH Tan, Christina TT Ha, Mei Yoke Chan, Ah Moy Tan. Annals Academy of Medicine Singapore 2015;44:530-4
A COMPREHENSIVE STUDY OF CURRENT HAEMOPHILIA CARE AND OUTCOMES IN SINGAPORE – HJ Ng, J Lam, PL Koh, L Ho, CY Lim, M Akhbar Ali, D Mya, H Than, LP Ho, AM Tan. LH Lee, SL Tien. Haemophilia 2015; 21(5):e428-431
RAPID-ONSET OBESITY WITH HYPOTHALAMIC DYSFUNCTION, HYPOVENTILATION, AND AUTONOMIC DYSREGULATION (ROHHAD) SYNDROME MAY HAVE A HYPOTHALAMUS – PERIAQUEDUCTAL GRAY LOCALIZATION – C Chow, MV Fortier, L Das, AP Menon, R Vasanwala, Joyce CM Lam, ZM Ng, SR Ling, DWS Chan, CT Choong, WKM Liew, T Thomas. Pediatric Neurology 2015; 52(5):521-5
CONGENITAL GATA1-MUTATED MYELOPROLIFERATIVE DISORDER IN TRISOMY 21 COMPLICATED BY PLACENTAL FETAL THROMBOTIC VASCULOPATHY – Tracy J.Z. Loh, Derrick W.Q. Lian, Prasad Iyer, Joyce C.M. Lam, Chik H. Kuick, Aye C.L. Aung, Kenneth Tou En Chang. Human Pathology 2014; 45: 2364–2367
DIAGNOSIS AND MANAGEMENT OF IRON DEFICIENCY ANAEMIA IN CHILDREN — A CLINICAL UPDATE – EC Chew, Lam JCM. Proceedings of Singapore Healthcare. 21(4): 278-85
INTESTINAL ATRESIA OCCURRING IN ASSOCIATION WITH PLACENTAL FETAL THROMBOTIC VASCULOPATHY: A CASE REPORT WITH LITERATURE REVIEW – Lian DQ, Lam JCM, Aung AC, Li FX, Chang TE. Pediatric and Developmental Pathology. 2013; 16(1):28-31
SKIN MANIFESTATION OF STENOTROPHOMONAS MALTOPHILIA INFECTION – A CASE REPORT AND REVIEW ARTICLE – Teo WY, Chan MY, Lam CM, Chong CY. Annals of the Academy of Medicine Singapore. Dec 2006; 35 (12):897-900
WHEN IS A MEDIASTINAL MASS CRITICAL IN A CHILD: AN ANALYSIS OF 29 PATIENTS – JCM Lam, CH Chui, AS Jacobsen, AM Tan, VT Joseph. Paediatric Surgery International, March 2004; 20 (3): 180-4