Clin Assoc Prof Tan Ah Moy

Prof Tan Ah Moy received her MBBS from National University of Singapore (NUS) in 1973. She passed her Master of Medicine (Paediatric) NUS in 1997. She received her postgraduate train ing in Paediatric Hematology/Oncology from Royal Children's Hospital, Melbourne under Ministry of Health Scholarship in 1986. Upon returning she has been actively involved in expansion and development of childhood cancer care in Singapore. She was a member of National Cancer Care Committee from 2000 to 2004. She was appointed as Adjunct Associate Professor in YLL School of Medicine in 2006 and subsequently as Adjunct Associate Professor, Duke -NUS School of Medicine and Lee Kong Chian School of Medicine.

From 1997 to 2012 she was appointed Head of Paediatric Hematology/Oncology Service in KKH. During her headship, KKH provided comprehensive programme for treatment of childhood cancer and blood disorders in Singapore. The Singapore Childhood Cancer Registry was started in 1997 and she is Director of SCCR. SCCR has a comprehensive internet enabled data repository and supports many research projects in childhood cancer. As Director of Hematopoietic Stem Cell Transplant in KKH and also a member of Singhealth Transplant Consortium and Viva-Asia BMT Consortium, she actively led the programme in research. She is involved in train ing clinical fellows from the region.

• FRCP (EDIN) 2004
• MMed Paediatrics (Singapore) 1977
• MBBS National University of Singapore 1973

• Adjunct Associate Professor, Yong Loo Lin School of Medicine
• Adjunct Associate Professor, Duke - NUS Graduate Medical School Singapore
• Adjunct Associate Professor, Lee Kong Chian School Of Medicine
• Senior Consultant, Department of Paediatrics Subspecialties, Paediatric Hematology/Oncology Service, KKH -2012 to Present
• Programme Director of KKH Hematopoietic Stem Cell Transplant 1998 to present
• Head of Paediatric Hematology/Oncology Service KKH 1997 - 2012
• Director of Singapore Ch ildhood Cancer Registry 2005 to present

• Outstanding Clinician Award, GCEO Excellence Award 2018
• National Day Long Service Award 2010
• Service from the Heart, KKH 2000, 2004, 2006, 2007, 2009, 2011, 2013, 2015
• Excellent Service Award Star 2005, 2012
• Long Service Award KKH 2005, 2014
• Best clinical research paper oral, Combined Scientific Meeting, Singhealth and National Health Group, 2005
• Best poster award, Singapore-Malaysia Congress of Med. 2002
• HMDP Fellowship in Paediatric Haematology/Oncology, Royal Children's Hospital. Melbourne 1 year 1986

• Blood and Marrow Transplantation in Children
• Cancer in Adolescent
• Cord Blood Transplant and Germ Cell Tumours

• PROPEL - Phase 3 prospective randomized multicenter clinical study comparing the safety and efficacy of BAX 855 fo llowing PK - guided prophylactic targeting 2 different FVIII trough levels in subjects with severe Haemophilia A. started 2016 - ongoing JLam, Tan AM, Rajat, Chan MY
• PROLONGATE - Phase 3 prospective multi-center open label study to investigate safety, immunogenicity and hemostatic efficacy of PEGLATED Factor VI II ( BAX 855) in previously untreated patients (PUPs)<6 years with severe haemophilia A (FVIII <1 )2017 ongoing. J Lam, Tan AM, Rajat, Chan MY
• EDOXABAN - Multicenter open label active controlled randmised study to evaluate the efficacy and safety of an age and body weight-adjusted rivaroxaban regime compared to standard of care in children with acute venous thromboembolism 2017 to date Lam J, Chan MY, Tan AM, Rajat B
• PROTECT VIII-A Phase II/III multicenrer Partial ly randomized, open trial investigating safety & Effficacy of on demand and prophylactic treatment with BAY 94-902& in severe haemophilia factor VII. Funded by Bayer Site PI Joyce Lam ,Co PI Tan AM completed in 2016
• Investigating 6-Mercaptopurine (6MP) Dose Intensity and Pharmacogenomics in Asian Children with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma. NMRC Sept 2017 to 2020 PI Allen Yeoh. Site PI Tan AM
• MASPORE ALL 2010. A risk stratified study using early response as risk stratification incorporating pharmacogenomics, gene expression and proteomic & cell banking. NMRC grant 2010 ongoing Yeoh A. Site PI Tan AM
• Malaysia - Singapore AML 2006 protocol reduced dose anthracycline reg ime for acute myeloid leukemia NMRC 2007 ongoing PI A Yeah A Site PI Tan AM.
• Exploring the CNS toxicity of dexamethasone in the treatment of Paediatric ALL:A multifaceted fMRI/MRS study including innovative use of Fitbit Trackers in children NMRC 2017 ongoing PI Allen Yeoh Site PI Tan AM
• Paired pre and post treatment whole genome gene expression profiling of bone marrow as a diagnostic and novel prognostic tool of childhood acute lymphoblastic and myeloid leukemia. A Malaysia - Singapore study. NMRC. Yeoh A. Site PI Tan AM
• Expanded Activated haploidentical natural killer infusions for relapse sarcoma MNRC 2015 ongoing PI Daria Campana I Tan PL. Site PI Tan AM
• Validation of a clinical screening instrument for tumour predisposition syndromes in childhood cancer patients and establishment of a perspective database 2015 Ngeow Joanna, Soh SY, Tan AM, Chan MY TCL research fund
• Multicenter Phase II Study for International intraocular retinoblastoma classification groups B, C & D Tumors treated with Carboplatin-etoposide-vinscritin e-cyclosporin- focal therapy Multimodali ty protocoi. (OCRN multicenter RB2003) 2009-2014. Site PI Tan AM, Quah BL, Soh SY
• The impact of the bravery beads programme on patients, their caregiver and health care professional. 2015- 2018 Funded by Singhealth PI Tan AM
• Expansion of an internet-enabled comprehensive long-term Singapore Childhood Cancer Registry - a POG (S'pore) Collaborative study 2005-2008, Singapore Cancer Syndicate Tan AM, Allen Yeah, Quah TC, Sethi
• Malaysia-Singapore ALL Rx protocol - a risk stratify study using early response to Rx as risk stratification incorporating pharmacogenomic, gene expression profiling, proteomic & cell banking NMRC 2004-2008 A Yeah, Tan AM, Quah TC, Chan MY, Hani Arriffin
• Neurodevelopmental effects for childhood ALL, KKH research fund and New Century Worldwide Hope Foundation, 2006 - 2015 J Lam, C Ha, Tan AM
• Setting up an infrastructure for clinical epidemiology & population-based case control studies in cancer. NMRC grant. 2008-2011. Chia KS, Tan AM, Tan CK, Yeah A, Ooi LL

• Whole-genome noncoding sequence analysis in T cell acute lymphoblastic leukemia identify oncogene enhancer mutations. Blood 2017 129: 33264-68;doi: https//dol. org 1 0 .1182/blood-2017 -03- 771 162 SY Hu, MX Qian,H Zhang, Y Guo,Y Yang, S Kow, TC Quah, AM Tan, A Yeoh, CH Pu i, JJ Yang
• Critically ill children with hemaphagocytic lymphohistiocytosis: A case Series of 14 patients. HM Leow, SH Soh, AM Tan,YH Mok,JH Lee J Pediatr Hematol Oncol,vol 39 no 6 Aug 2017 e303-e306
• Whole Transcriptome sequencing identified a distinct subtype of ALL with predominant genomic abnormalities of EP300 and CREBBP Genome Res 2016 Nov 30.pii gr 209163.116 Maoxiang Q, Hui Z ,Shirley K, AM Tan,Hany A ,Ching HP, Allen Y, Jun J Y
• Management of a Kaposiform haemangioendothelioma of the kidney with Kasabach-Meritt phenomenon without chemotherapy. Mya SN, Amos Loh, AM Tan, J Lam, K Chang Paed Hemato & Oncology Journal 2017 89-92
• Langerhans cell histiocytosis : another cause of a fluid-fluid level within an appendicular bony lesion. V R Krishna, MY Leong, AM Tan, D Lian, H Teo BJR 2016:2:20150408
• Acute lymphoblastic leukemia in a child with a de novo germline gnb1 mutation M Brett,Angeline Lai, TW Tan, AM Tan, R Foo, Saumya J, EC Tan. AJMG Oct 2016 DOI:10.1002/ajmg.a.38026
• A case of Eczematoid graft versus host disease JH Chong, K Tawng, HM Liew, AM Tan, M Koh Pediatric Dermatology 1-3 2016 DOl 10.1111/pde.12840
• Viva-Asia Blood and Marrow Transplantation groups - A survey of consortium activity over a 12 year period (2000 to 2011 ) AM Tan,C Ha, CF Li, G Chan, V lee, PL Tan, S Hongeng, K Sanakit,A Lee,HP Lin, MRosario, J Chen. Annals 201 6;45:3: 106-9
• TCR αβ and CD 19 - depleted haploidentical stem cell transplant with reduced intensity conditioning for Hoyeraai-Hredarsson Syndrome with RTEL 1 mutation R Bhattacharyya, AM Tan, MY Chan ,SS Janur, R Foo, P lyer BMT 2016;51 :753-4
• A case of Cutaneous Penicilliosis in a child with acute myeloid leukemiaS G Krishnan, N Tee, AL Tan, AM Tan, M Koh, CY Chong, N Tan. JMM 2015; DOl 10.1099/jmmcr.0.000098.
• Neuroblastoma in children under 12 months in Singapore - 15 year experience and outcomes from KKH. Koh V, Sy Soh, MY chan, AM Tan Fetal Pediatr Pathol, 2015 ; 14.100.132.188 (Dol: 10.31 09/15513815.2014.999392)
• A comprehensive study of current haemophilia care and outcomes in Singapore. HJ Ng, J Lam, PL Koh, LP Ho, AM Tan, LH Lee and SL Tien. Haemophilia 20151 -4 DOI:1111/hae.12729
• Causative pathogens of febrile neutropaenia in children treated for acute lymphoblastic leukaemia. J Lam, JY Chai, YL Wong, N Tan, C Ha, MY Chan, AM Tan Annals 2015:44;530-4
• Atypical Location and clinical behavior of non-teratomatous intracranial germ cell tumours in children younger than 3 years of age. Teo WY, Seow WT, Tan AM JNSPJ 2014 2014DOI: 1 0.3171/2014.PEDS13651 : 1-8
• Host genetic varaiants of ABCB1 and IL 15 influence treatment outcome in paediatric acute lymphoblastic leukemia. Y Lu, SKY Kham, H ariffin, AMI Oei, HP Lin, AM Tan, TC Quah, AEJ Yeoh BJC 2014, 1-8 doi:1038/bjc.2014.7
• Allogeneic stem cell transplantation for children with acquired severe aplastic anaemia: a retrospective study by the Viva-Asia Blood and Marrow Transplantation Group. J Chen, V Lee, CJ Luo, A Kwok, PL Tan, AM Tan, Y Okamato BJH 2013;162:383-391
• Association of trisomy 18 with hepatoblastoma and its implications. ZH Tan, A Lai, CK Chen, K Chang, AM Tan European J Pediatr Aug 2013 D0110.1007/s00431-01 3-2147-8
• Langerhans Cell Histiocytosis - A mimicker of tuberculosis of the spine. Teo WY, Tan AM, Chan MY, J of Paed & Child Health 2012;48: 1105-6
• Clinical profile, management and outcome of retinoblastoma - a report from a Children's Hospital in Singapore. Lim F, Soh SY, Tan AM, Handa S, Quah BL. JPOS 2013;50:106-112
• Minimal residual disease-guided treatment deintensification for children with acute lymphoblastic leukemia: results from the Malaysia-Singapore Acute Lymphoblastic Leukemia 2003 study. - Yeoh AE, Ariffin H, Chai EL, Kwok CS, Chan YH, Ponnudurai K, Campana D, Tan PL, Chan MY, Kham SK, Chong LA, Tan AM, Lin HP, Quah TC. JCO 2012,30:19:2384-2392
• Bony presentations of childhood haematological malignancy to the emergency room. Teo WY, Chan MY, Ng KC, Tan AM. Journal of Pediatrics and Child Health 201 1, Dol: 10.1111,1440-1754.
• Use of deperiprone for iron chelation in patients with transfusion-dependent thalassemia. Shekhar S, Lai A, Tan AM, Chan MY, Ng I. Journal of Paed & Child Health. 2011 , Dol: 10.11 1, 1440-1754.
• Painless abdominal distension in children.Chua HY, Loh HP, Tan AM. JPOG 2010;36:5:181-189.
• Aggressive subcutaneous panniculitis-like T-celllymphoma with hemophagocytosis in two children (subcutaneous panniculitis-like T-cell lymphoma). Koh MJ, Sadarangani SP, Chan YC, Chan MY, Tan AM, Tan SH, Tay YK, Ng SB. J Am Acad Dermatol. 2009 Nov; 61 (5):875