Asst Prof Wan-Yee Teo

​Dr. Wan-Yee Teo, a clinician-scientist, is Head and Principal Investigator of the Pediatric Brain Tumor Research Office at SingHealth Duke-NUS Academic Medical Centre, Singapore. She is Vice President of the College of Clinician Scientists, Academy of Medicine, Singapore. She completed her clinical training in Pediatrics and Pediatric NeuroOncology in the USA, and is board certified with the American Board of Pediatrics, and the Royal College of Pediatrics and Child Health in the UK. Her research training was completed in the Cancer Genomics Program at Baylor College of Medicine, USA. Her research combines genomic methodologies and mouse models to study the complex regulation in the developmental biology of brain tumors.

Her group conducts their research at the Laboratory of Pediatric Brain Tumor Research Office at SingHealth Duke-NUS Academic Medical Center, Singapore. The research focuses on the brain tumor microenvironment, particularly in pediatric brain tumors, and translating research findings in tumor biology and genomics to bedside benefits for children with brain tumors. An area of emphasis is the preclinical development of therapeutics for brain tumors using patient-derived brain tumor xenograft modelling. Dr Teo established a competitive laboratory and the Pediatric Brain Tumor Research Office (PBTRO) at SingHealth Duke-NUS Academic Medical Centre, Singapore, in May 2015. She was awarded the SingHealth @IMCB Program Grant to expand two programs in her laboratory (1) Cell Cycle Therapeutic Development Program for Human Cancers, and (2) Artificial Intelligence Laboratory for Human Cancer Translation.

• American Board of Paediatrics Board Certification
• PhD, Nanyang Technological University of Singapore (School of Biological Sciences), Singapore
• Residency, Paediatrics, Inova Children’s Hospital, Virginia Commonwealth University, USA
• Fellowship, Paediatric NeuroOncology, Baylor College of Medicine, Texas Children’s Hospital, USA
• Postdoctoral Research Fellowship, Texas Children’s Hematology & Cancer Centers, USA
• MRCPCH, Royal College of Paediatrics & Child Health, UK
• MBBS, School of Medicine, National University of Singapore, Singapore

• ​Vice President, College of Clinician Scientists, Academy of Medicine, Singapore
• Duke-NUS Medical School Research and Scholarship Committee, Singapore
• Fellow of American Academy of Pediatrics
• Fellow of American Academy of Pediatrics, Section of Hematology/Oncology
• Member of Royal College of Pediatrics and Child Health, UK

• Long Service Award, KK Women’s & Children’s Hospital. SingHealth.
• Ministry of Health-National Medical Research Council (Singapore) Clinician-Scientist Award (#2)
• Ministry of Health-National Medical Research Council (Singapore) Clinician-Scientist Award (#1)
• Ministry of Health-National Medical Research Council (Singapore) Transition Award
• Richard Schwartz, MD Teaching Award for Excellence, USA
• Hoshino Award for Young Investigator at 3^rd World Federation of Neuro-Oncology by Society for Neuro-Oncology (US), European Association of Neuro-Oncology (EANO) & Asian Society for Neuro-Oncology (ASNO)
• Travel Fellowship Award for Outstanding Abstract by Asian Society for Pediatric Research at 4^th Congress of ASPR at Pediatric Academic Societies' & Asian Society for Pediatric Research Joint Annual Meeting
• Ministry of Health-National Medical Research Council (Singapore) Research Training Fellowship Award      
• Finalist for Young Investigator Award, 43^rd Singapore-Malaysia Congress           
• 2^nd Runner-up ENT Bookprize Competition (Faculty of Medicine, National University of Singapore, Singapore Society of Otorhinolaryngology)

Selected Peer-reviewed Publications

• Teo WY, Tan HK, Goh BC, Putti TC. Postirradiation sarcoma of the sphenoid bone--a case report. Ann Acad Med Singapore. 2006;35(2):104-7.
• Teo WY, Chan MY, Lam CM, Chong CY. Skin manifestation of Stenotrophomonas maltophilia infection--a case report and review article. Ann Acad Med Singapore. 2006;35(12):897-900.*
• Chan MY, Teo WY, Seow WT, Tan AM. Epidemiology, management and treatment outcome of medulloblastoma in Singapore. Ann Acad Med Singapore. 2007;36(5):314-8.
• Teo WY, Loh TF, Tan AM. Avoiding dialysis in tumour lysis syndrome: is urate oxidase effective? - a case report and review of literature. Ann Acad Med Singapore. 2007;36(8):679-83.*
• Teo WY, Choong CT. Neurological presentations of conversion disorders in a group of Singapore children. Paediatr International. 2008;50(4):533-6.*
• Teo WY, Chan MY, Ng KC, Tan AM. Bony presentations of childhood hematological malignancies in the emergency room. J Paediatr Child Health. 2012;48(4):311-316.*
• Teo WY, Chintagumpala M, Okcu MF, Dauser RC, Mahajan A, Adesina AM, Whitehead WE, Jea A, Bollo R, Paulino AC. A retrospective analysis of the patterns of failure in paediatric myxopapillary ependymoma. J Radiat Oncol. 2013;2(1):21-26.*
• Teo WY, JMF Su, Shen JS, Yu A, Wang J, Chow WY, Li XN, Dauser R, Whitehead W, Adesina AM, Chintagumpala M, Man TZ, Lau CC. Implications of tumor locations on subtypes of medulloblastoma (Priority Report with Commentary Highlight). Ped Blood and Cancer. 2013;60(9):1408-10.
• Teo WY, Myseros JM. The gut or the brain? –Gastrointestinal Misdiagnoses of Infantile Brain Tumors. Childs Nerv Syst.  2014;30(8):1449-53.*
• Teo WY, Ross J, Bollo RJ, Seow WT, Tan AM, Kang SG, Kim DS, Mohila CA, Li XN, Lau CC, Adesina AM, Su JMF. Atypical location and clinical behavior of non-teratomatous intracranial germ cell tumors in children. Journal of Neurosurgery-Paediatrics. 2014;25:1-8.* (Podcast Highlight by journal)
• Teo WY, Kim S, Mensah-Bonsu N. The Curious Case of Ileocolic Intussusception. J Paediatr Child Health. 2014;50(7):573-4.*
• Teo WY, Dulman RY, Vinh T. Lung Opacification. JAMA. 2014;311(23):2434-5.*
• Teo WY, Elghetany MT, Shen J, Man TK, Li XN, Chintagumpala M, Su JMF, Dauser R, Whitehead W, Adesina AM, Lau CC. Therapeutic implications of CD1d expression and tumor-infiltrating macrophages in paediatric medulloblastomas. Journal of NeuroOncology. 2014;120(2):293-301.*
• Lindsay H, Huang Y, Du Y, Braun FK, Teo WY, Kogiso M, Qi L, Zhang H, Zhao S, Mao H, Lin F, Baxter P, Su JM, Terashima K, Perlaky L, Chintagumpala M, Adesina A, Lau CC, Parsons DW, Li XN. Preservation of KIT genotype in a novel pair of patient derived orthotopic xenograft mouse models of metastatic paediatric CNS germinoma. Journal of NeuroOncology. 2016;128(1):47-56.
• Teo WY, Sekar K, Seshachalam P, Shen J, Chow WY, Lau CC, Yang H, Park J, Kang SG, Li X, Nam DH, Hui KM. Relevance of a TCGA-derived Glioblastoma Subtype Gene-Classifier among Patient Populations. Sci Rep. 2019 May 15;9(1):7442.* Top 100 Most Downloaded Cancer Articles in Scientific Reports in 2019.
• Teo WY, Sriram B, Alim AA, Ruan X, Rajadurai VS. A single-center observational study on congenital diaphragmatic hernia: Outcome, predictors of mortality and experience from a tertiary perinatal center in Singapore. Pediatr Neonatol. 2020 Mar 13:S1875-9572(20)30042-5.*
• Teo WY. Implications for Border Containment Strategies when COVID-19 Presents Atypically. Public Health (Official Journal of Royal Society of Public Health, UK). 2020 July 13 (in press).
  DOI: 10.1016/j.puhe.2020.07.019.*
  
• Yoon SJ, Son HY, Shim JK, Moon JH, Kim EH, Chang JH, Teo WY, Kim SH, Park SW, Huh YM, Kang SG. Co-expression of cancer driver genes: IDH-wildtype glioblastoma-derived tumorspheres. J Transl Med. 2020 Dec 14;18(1):482. doi: 10.1186/s12967-020-02647-8.
  

* Corresponding Author