Erlotinib is used to treat non-small cell lung and pancreatic cancer.
Avoid taking certain fruits such as grapefruit, pomelo, starfruit and pomegranate when you are taking this medication. This is because these fruits may may affect how the body processes the drug and increase the risk of side-effects.
The table below will list some of the common side effects as well as the rare but serious side effects.
| Side Effect | Management |
| Nausea or vomiting |
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Diarrhoea (loose and frequent stools)
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Mouth ulcers or sores.
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| Eye dryness causing discomfort, redness and increased production of tears |
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| Feeling tired or lack of energy |
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Acne-like rashes (pimples) may appear on the face, upper chest and back.
It usually develops within the first 2 weeks of treatment and will get better after stopping treatment.
Your skin may also become flaky and scaly. |
|
| Liver problems | Proceed to the A&E department immediately if you experience any:
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| Lung problems | Proceed to the A&E department immediately if you have any new or worsening symptoms of lung problems such as shortness of breath, cough or chest pain. |
Symptoms of drug allergy including one or more of the following:
Itchy skin rashes over your whole body |
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It is normal to experience some side effects from Erlotinib. As discussed with your doctor, taking Erlotinib will be beneficial for your condition. Do not stop taking Erlotinib without checking with your doctor.
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
For general waste: Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.
Tips to help manage your condition while you are on Erlotinib
| Exercise | Light exercise is recommended as it helps to improve mobility, balance, and even emotional well-being. Avoid strenuous exercise, and rest when you are feeling tired. |
| Adequate hydration | Have plenty of hydration with 2 to 3 litres of fluids per day unless you have been informed by your doctor to limit how much fluids you can drink. This will decrease your chances of getting constipation and prevent dehydration. |
| Medical and dental treatment | If you need to go into hospital for any reason other than cancer, always inform the doctors and nurses that you are receiving anti-cancer treatment. Talk to your cancer doctor if you think you need dental treatment. Always inform your dentist that you are receiving anti-cancer treatment. |
| Seek support if you feel overwhelmed | It is normal to feel fearful or worried about your condition. Do not be afraid to share your concerns with your healthcare team or loved ones. There may be resources and support available to help you. |
Disclaimers
Please take note that the above is not a complete list of all possible side-effects. If you have any concerns about your medication or if you have other side-effects that you think are caused by this medication, please consult your doctor or pharmacist. If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (NHG Health, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
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