Paclitaxel

What is Paclitaxel for?

Paclitaxel is a chemotherapy drug used to treat certain types of cancer such as ovarian, breast, lung, head and neck, and bladder cancer. It may be used in combination with other types of chemotherapy drugs.

How should I take or use Paclitaxel?

Paclitaxel is given via an injection into the vein, as an infusion (drip).

What precautions should I take when taking or using Paclitaxel?

Inform your healthcare professional if:

• You are allergic to this medication or any of the other ingredients of this medication
• You are pregnant, planning to become pregnant, or breastfeeding
• You are taking any other medications, including supplements, traditional medications and herbal remedies

What food or medication should I avoid when I take or use Paclitaxel?

Avoid taking grapefruit when you are on this medication as it will interact with grapefruit that may increase the risk of side-effects.

Avoid taking traditional chinese medications (TCM) or ‘jamu’ when you are on this medication.

What are some common side effects of Paclitaxel?

• Early side-effects
  • Allergic reaction
    • Please let your nurses know if you have any breathlessness, chest discomfort, warm sensation, itchy rashes, or any other discomfort during the infusion
  • Mild nausea and vomiting
    • You may be given anti-vomiting medications, take them as directed to help prevent or decrease these side effects.
    • Take small, frequent meals.
  • Joint and muscle pain or weakness
    • You can take paracetamol (Panadol) to help with muscle and joint aches if you do not have fever
• Delayed side-effects
  • Diarrhea
    • Drink at least two litres (8 cups) of fluids every day if you are having diarrhea, unless you have been advised otherwise by your doctor to limit your fluid intake
    • Avoid milk, dairy products, high-fibre food, or spicy food if you are having diarrhea.
  • A drop in the blood cell counts. This may put you at a higher risk of infections, bleeding or bruising, or feeling tired.
    • To reduce risks of getting an infection, practise good personal hygiene, avoid crowded places or people who are sick and avoid eating raw food
    • To reduce risks of bleeding and bruising, do not pick your nose. Brush your teeth with a soft-bristled toothbrush.
    • If you are feeling tired, do not drive or engage in activities that require concentration.
  • Temporary hair loss
    • Wear a wig or hat, and use a gentle shampoo
  • Numbness, tingling or burning sensation on fingers and toes
    • Inform your doctor if you are bothered by this symptom or have trouble buttoning up shirts or picking up objects
  • Mouth ulcers and/or tenderness
    • Brush your teeth after eating and at bedtime with a soft toothbrush
    • Rinse and brush your dentures after eating and soak them in denture solution overnight
    • Rinse your mouth regularly with an alcohol-free mouthwash or salt water. This will help to reduce chances of an infection

What are some rare but serious side effects that I need to seek medical advice immediately?

• Fever of 38° C or higher
• Unusual bleeding, bruising, or black tarry stools