Thiopurine S-Methyltransferase (TPMT) and Nudix Hydrolase 15 (NUDT15) Genotyping

Specimen Container	EDTA tube
Specimen Requirement	Whole Blood EDTA Adult: 6 mL Paediatric: 3 mL
Specimen Storage/Transport	Refrigerate sample until transfer to laboratory. Do not freeze. Sample should reach the laboratory as soon as possible, preferably within 72 hours after collection.
Orderable as Urgent?	No
Turn Around Time	1 – 3 days
Testing Laboratory Location	TTSH
Laboratory	Molecular Diagnostic Laboratory
Contact Number	6394 1352
Day and Time Performed	Mon - Fri: 0800 hrs to 1700 hrs Sat: 0800 hrs to 1200 hrs
Orderable on CPOE?	No
Downtime Form	Clinical Chemistry - Form A
Additional Information	This assay tests for TPMT *3 (c.460G>A, c.719A>G) and NUDT15 (c.415C>T) to aid prediction for toxicity to thiopurine drugs.

Change History Notes

Last Updated - 27 May 2025