Dr Ngoh Seow Fen Adeline

CCT Paediatrics & Paediatric Neurology (UK), MRCPCH (UK), MBBS (UK)

Consultant

KK Women's and Children's Hospital

Specialty: Paediatric Neurology

Conditions Treated by this Doctor:
Epilepsy, Headache in Children, Headaches, Movement Disorders, Neurodevelopmental Disorders.

Clinical Appointments

Consultant Neurology Service KK Women's and Children's Hospital

Profile

Dr Adeline Ngoh completed her basic medical training in Barts and The London School of Medicine and Dentistry, UK. After specialist training in Paediatrics in various hospitals in London, she was appointed through a highly competitive national selection process to Paediatric Neurology sub-specialty training at Great Ormond Street Hospital for Children, London, UK and Addenbrooke’s Hospital, Cambridge, UK. She received joint specialist accreditation in General Paediatrics and Paediatric Neurology, UK in September 2019.

She is currently completing her PhD research in Developmental Neuroscience on Molecular Genetics and Epileptic Encephalopathy at University College London (UCL) Great Ormond Street, Institute of Child Health, UK, with a research award from Action Medical Research, UK, and Guarantors of Brain. She has also recently received a separate research grant from the Paediatrics Academic Clinical Programme, Singapore, to evaluate genetic variants in refractory epilepsy.

Her research interests lie in studying genetic contribution to neurodevelopmental disorders, particularly childhood epilepsy, to advance our understanding of disease mechanisms underlying these disorders. She hopes that better understanding of disease mechanisms can, in time, pave the way to more effective treatment strategies.

Education

CCT in Paediatrics and Paediatric Neurology (UK) 2019
MRCPCH (UK) 2010
MBBS (UK) 2005

Professional Appointments and Committee Memberships

Consultant, Department of Paediatric Neurology, KK Women’s and Children’s Hospital 2022 - Present

Awards

ILAE International Epilepsy Congress Best Platform Presentation Award, 2019
Action Medical Research Training Fellowship Award, 2015
Guarantors of Brain Entry Fellowship Award, 2014
Friends of Landau Kleffner Syndrome Research Award, 2013
Guarantors of Brain Travel Grant Award, 2007
Charrington Prize for Excellence in Final M.B.B.S., 2005
Sutton Prize for Dissertation on Pharmacogenomics, 2005
Elective Award (Worshipful Society of Founders), 2005
Brackenbury Bourne and Magdalen Hughes Scholarship Prize in Medicine – 2004
Elective Award (National University Hospital), 2004
Buxton Prize (B) in Anatomy, Physiology and Biochemistry – overall best pre-clinical performance, 2003
Merit Awards for Excellence in Medical School Examinations 2001-2005

Research Interests

Genetic contribution to neurological disorders/childhood epilepsy

Publications

Ngoh A, Barwick K, Trump N, Clark M, Cross JH, Kullmann D, Harvey RJ, Kurian MA. Genetic Heterogeneity In Landau-Kleffner Syndrome. Epilepsia. 2019; 60: 8-9
Ngoh A, Lynch J, Reid K, Clark M, Moulding D, Malhotra S, Topf M, Erdem FA, Cross JH, Kullmann D, Harvey RJ. Functional Characterization Of GRIN2A Mutations In Landau-Kleffner Syndrome. Epilepsia. 2019; 60: 29-30
Ngoh A, Yap ZM, Chan DW. Diagnostic Yield Of Genetic Testing In Epileptic Encephalopathy. Epilepsia 2019; 60: 197-197
Ng J, Barral S, Barrigon CD, Lignani G, Erdem FA, Wallings R, Privolizzi R, Meyer E, Alrashidi H, Heasman S, Ngoh A. Gene Therapy for Infantile Parkinsonism. Molecular Therapy. 2019; 27 (4): 257-257
Kumar P, Shih DCW, Lim A, Paleja B, Ling S, Li Yun L, Li Poh S, Ngoh A, Arkachaisri T, Yeo JG, Albani S. Pro-inflammatory, IL-17 pathways dominate the architecture of the immunome in pediatric refractory epilepsy. JCI Insight. 2019; 4(8): e126337
McTague A, Nair U, Malhotra S, Meyer E, Trump N, Gazina EV, Papandreou A, Ngoh A, Ackermann S, Ambegaonkar G, Appleton R, Desurkar A, Eltze C, Kneen R , Kumar AV, Lascelles K, Montgomery T, Ramesh V, Samanta R, Scott RH, Tan J, Whitehouse W, Poduri A, Scheffer IE, Chong WKK, Cross JH2, Topf M, Petrou S, Kurian MA. Clinical and molecular characterization of KCNT1-related severe early-onset epilepsy. Neurology. 2018;90(1):e55-e66.
Ngoh A, Parker A. New Developments in Epilepsy Management. Invited Review. Paediatrics and Child Health. 2017; 27(6): 281-286
Ngoh A, Bras J, Guerreiro R, McTague A, Ng J, Meyer E, Chong WK, Boyd S, MacLellan L, Kirkpatrick M, Kurian MA. TBC1D24 Mutations in a Sibship with Multifocal Polymyoclonus. Tremor Other Hyperkinet Mov (N Y). 2017; 7:452
Meyer E, Carss KJ, Rankin J, Nichols JM, Grozeva D, Joseph AP, Mencacci NE, Papandreou A, Ng J, Barral S, Ngoh A, Ben-Pazi H, Willemsen MA, Arkadir D, Barnicoat A, Bergman H, Bhate S, Boys A, Darin N, Foulds N, Gutowski N, Hills A, Houlden H, Hurst JA, Israel Z, Kaminska M, Limousin P, Lumsden D, McKee S, Misra S, Mohammed SS, Nakou V, Nicolai J, Nilsson M, Pall H, Peall KJ, Peters GB, Prabhakar P, Reuter MS, Rump P, Segel R, Sinnema M, Smith M, Turnpenny P, White SM, Wieczorek D, Wiethoff S, Wilson BT, Winter G, Wragg C, Pope S, Heales SJ, Morrogh D; UK10K Consortium; Deciphering Developmental Disorders Study; NIHR BioResource Rare Diseases Consortium, Pittman A, Carr LJ, Perez-Dueñas B, Lin JP, Reis A, Gahl WA, Toro C, Bhatia KP, Wood NW, Kamsteeg EJ, Chong WK, Gissen P, Topf M, Dale RC, Chubb JR, Raymond FL, Kurian MA. Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia. Nat Genet. Erratum in: Nat Genet. 2017; 49(6):969
Meyer E, Carss KJ, Rankin J, Nichols JM., Grozeva, D, Joseph AP, Mencacci NE, Papandreou A., Ng J, Barral S, Ngoh A, Ben-Pazi H, Willemsen MA, Arkadir D, Barnicoat A, Bergman H, Bhate S, Boys A, Darin N, Foulds N, Gutowski N, Hills A, Houlden H, Hurst JA, Israel Z, Kaminska M, Limousin P, Lumsden D, McKee S, Misra S, Mohammed SS, Nakou V, Nicolai J, Nilsson M, Pall H, Peall KJ, Peters GB, Prabhakar P, Reuter MS, Rump P, Segel R, Sinnema M, Smith M, Turnpenny P, White SM, Wieczorek D, Wiethoff S, Wilson BT, Winter G, Wragg C, Pope S, Heales SJ, Morrogh D, Pittman A, Carr LJ, Perez-Duenas B, Lin JP, Reis A, Gahl WA, Toro C, Bhatia KP, Wood NW, Kamsteeg EJ, Chong WK, Gissen P, Topf M, Dale RC, Chubb JR, Raymond FL, Kurian MA. Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia. Nature genetics. 2017; 49(2): 223-37 (Impact factor: 27.959)
Sframeli M, Sarkozy A, Bertoli M, Astrea G, Hudson J, Scoto M, Mein R, Yau M, Phadke R, Feng L, Sewry C, Fen ANS, Longman C, McCullagh G, Straub V, Robb S, Manzur A, Bushby K, Muntoni F. Congenital muscular dystrophies in the UK population: Clinical and molecular spectrum of a large cohort diagnosed over a 12-year period. Neuromuscul Disord. 2017; 27(9):793-803.
Ngoh A, Bras J, Guerreiro R, Meyer E, McTague A, Dawson E, Mankad K, Gunny R, Clayton P, Mills PB, Thornton R, Lai M, Forsyth R, Kurian MA. RARS2 mutations in a sibship with infantile spasms. Epilepsia. 2016; 57(5):e97-e102. doi: 10.1111/epi.13358
Papandreou A, McTague A, Trump N, Ambegaonkar G, Ngoh A, Meyer E, Scott RH, Kurian MA. GABRB3 mutations: a new and emerging cause of early infantile epileptic encephalopathy. Dev Med Child Neurol. 2016;58(4):416-420.
Papandreou A, Schneider RB, Augustine EF, Ng J, Mankad K, Meyer E, McTague A, Ngoh A, Hemingway C, Robinson R, Varadkar SM, Kinali M, Salpietro V, O'Driscoll MC, Basheer SN, Webster RI, Mohammad SS, Pula S, McGowan M, Trump N, Jenkins L, Elmslie F, Scott RH, Hurst JA, Perez-Duenas B, Paciorkowski AR, Kurian MA. Delineation of the movement disorders associated with FOXG1 mutations. Neurology. 2016; 86(19):1794-1800
Trump N, McTague A, Brittain H, Papandreou A, Meyer E, Ngoh A, Palmer R, Morrogh D, Boustred C, Hurst JA, Jenkins L, Kurian MA, Scott RH. Improving diagnosis and broadening the phenotypes in early-onset seizure and severe developmental delay disorders through gene panel analysis. J Med Genet. 2016; 53(5):310-317.
Mctague A, Papandreou A, Ngoh A, Ackermann S, Ambegaonkar G, Appleton R, Cross J, Desurkar A, Eltze C, Kneen R, Kumar A. KCNT1 mutations in epilepsy of infancy with migrating focal seizures-emerging phenotypic features and future treatment strategies. Developmental Medicine & Child Neurology; 2015; 57.
Mctague A, Papandreou A, Trump N, Ngoh A, Scott R, Ambegaonkar G, Kurian M. The first UK case of GABRBR3 mutation causing early onset epilepsy and developmental delay. Developmental Medicine & Child Neurology; 2015;57:27-28.
Rathod DP, Ngoh A, Krishnakumar DD, Chitre M. Non-thyroidal illness associated with aseptic meningitis in a child. European Journal of Paediatric Neurology, 2015; 19: S129
Ngoh A, McTague A, Wentzensen IM, Meyer E, Applegate C, Kossoff EH, Batista DA, Wang T, Kurian MA. Severe infantile epileptic encephalopathy due to mutations in PLCB1: expansion of the genotypic and phenotypic disease spectrum. Dev Med Child Neurol. 2014; 56(11):1124-1128.
A McTague, I Wentzensen, E Meyer, A Ngoh, Applegate C, Batista D, Kossof E, Wang T, Kurian MA. Mutations in PLCB1 in early infantile epileptic encephalopathy: expansion of the phenotypic and genotypic disease spectrum. European Journal of Paediatric Neurology. 2013; 17:S57
Malaspina A, Ngoh SF, Ward RE, Hall JC, Tai FW, Yip PK, Jones C, Jokic N, Averill SA, Michael-Titus AT, Priestley JV. Activation transcription factor-3 activation and the development of spinal cord degeneration in a rat model of amyotrophic lateral sclerosis. Neuroscience. 2010;169(2):812-827