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Clin Assoc Prof Kenneth Chang Tou En

Clin Assoc Prof Chang Tou En Kenneth


Head & Senior Consultant

KK Women's and Children's Hospital

Specialty: Pathology & Laboratory Medicine, Histopathology

Clinical Appointments

  • Head & Senior Consultant Department of Pathology and Laboratory Medicine KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Senior Consultant Paediatric Brain and Solid Tumour Programme KK Women's and Children's HospitalKK Women's and Children's Hospital
  • SingHealth Tissue Repository (STR) SingHealthSingHealth
  • Advanced Molecular Pathology Laboratory (AMPL) SingHealthSingHealth


Adj Assoc Prof Kenneth Chang is senior consultant paediatric pathologist and Head of Department, Department of Pathology and Laboratory Medicine at KK Women’s and Children’s Hospital in Singapore. He is Adjunct Associate Professor at Duke-NUS Medical School, and Academic Vice-Chair for Clinical Service Innovation in the SingHealth Duke-NUS Pathology Academic Clinical Programme. He is a Principal Investigator in the VIVA-KKH Paediatric Brain and Solid Tumours Programme. He is also Director of the SingHealth Tissue Repository and Advanced Molecular Pathology Laboratory, which are core research platforms in the SingHealth Academic Medical Centre.

Adj Assoc Prof Chang trained in paediatric pathology at the Hospital for Sick Children in Toronto, Canada and University of Toronto, completing a 2-year clinical fellowship from 2007 to 2009. More recently in the summer of 2015, he was a visiting fellow at the University of British Columbia and BC Cancer Agency. Currently, he is a Council Member in the International Paediatric Pathology Association, and plays a role in outreach to paediatric pathologists in the Asia-Pacific region.

His research interests include molecular diagnostics in relation to paediatric cancers, paediatric sarcomas with a focus on BCOR-mutated sarcomas, and placental pathology. He has published more than 80 scientific articles and 5 book chapters.


Professional Appointments and Committee Memberships


Research Interests

  • VIVA-KKH paediatric brain and solid tumours programme
  • Molecular analysis of paediatric tumours
  • Placental pathology
  • The regulatory factors of Hippo tumour suppressor pathway and their roles in cancer development
  • Cancer stem cell, oncogenic pathway and modelling of human neuoblastoma and other cancers


Research Trials