Clin Assoc Prof Kenneth Chang Tou En

MBChB, FRCPath

Senior Consultant

KK Women's and Children's Hospital

Specialty: Pathology ＆ Laboratory Medicine, Histopathology, Histopathology

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About

Education and Training

Professional Appointments and Committee Memberships

Awards

Research Interests

Publications

Clinical Interests

Histopathology, Pathology ＆ Laboratory Medicine

Clinical Appointments

Deputy Chairman

Clinical Support Services Division

Senior Consultant
Head, Molecular Pathology

Pathology and Laboratory Medicine

Director, SingHealth Tissue Repository (STR)

Director, Advanced Molecular Pathology Laboratory (AMPL)

Academic Appointments

Academic Vice-Chair (Clinical Care Transformation)

Pathology Academic Clinical Programme

About

Clin Assoc Prof Kenneth Chang is a senior consultant pathologist and Deputy Chairman, Division of Clinical Support Services at KK Women’s and Children’s Hospital in Singapore. He is Clinical Associate Professor at Duke-NUS Medical School, and Academic Vice-Chair for Clinical Service Transformation in the SingHealth Duke-NUS Pathology Academic Clinical Programme. Within the SingHealth cluster, he is Director of the SingHealth Tissue Repository and Advanced Molecular Pathology Laboratory. He is the programme lead of the St Jude-KKH Asia-Pacific Paediatric Pathology Programme, a regional paediatric pathology programme supported by St Jude Children’s Research Hospital, focused on capacity building for paediatric oncological pathology amongst a network of children’s hospitals in Asia. He is also Visiting Professor at the Shanghai Children’s Medical Centre/Jiao Tong University, in Shanghai, People’s Republic of China. Kenneth is an editorial board member of Pediatric and Developmental Pathology. He is an author and contributor to the current (fifth) edition of the World Health Organization Classification of Tumours. He has published numerous book chapters and more than 150 scientific articles. Kenneth’s research interests are in molecular test development for paediatric cancers, and in BCOR-mutated tumours.

Education and Training

MBA (2025)
FRCPath (2006)
MBChB (1999)

Professional Appointments and Committee Memberships

Principal Investigator, Viva-KKH Paediatric Brain and Solid Tumour Programme, KKH
Platform lead for Pathology and Molecular Pathology, Childhood Brain and Cancer Centre, KKH
Programme Lead, St. Jude-KKH Asia-Pacific Paediatric Pathology Programme
Editorial Board Member, Pediatric and Developmental Pathology
Member, International Affairs Committee, Association for Molecular Pathology

Awards

Health Manpower Development Plan individual award, Ministry of Health, Singapore – Clinical Fellowship in Paediatric Pathology and Paediatric Molecular Diagnostics at the Hospital for Sick Children/ University of Toronto, Toronto, Canada, July 2007-June 2009
Health Manpower Development Plan team award, Ministry of Health, Singapore – Establishment of a congenital hyperinsulinism multidisciplinary service for KK Women’s and Children’s Hospital, at Great Ormond Street Hospital, London, United Kingdom, January 2015
Inspiring mentor award, at 6th PATH-ACP Research Day, SingHealth Duke-NUS Pathology Academic Clinical Programme, 2019
Inspiring mentor award, at 7th PATH-ACP Research Day, SingHealth Duke-NUS Pathology Academic Clinical Programme, 2020
SingHealth Publish! Award 2019
SingHealth – KKH Long Service (20 years) Award 2021
SingHealth Excellence Awards 2021 – Distinguished Champion of Change Leader Award, June 2021
Inspiring mentor award, at 8th PATH-ACP Research Day, SingHealth Duke-NUS Pathology Academic Clinical Programme, 2021
Singapore Health Quality Service Award 2022 (Silver Award)
Outstanding faculty award, SingHealth RiSE (Residency in SingHealth Excels!) Awards 2022
Ministry of Health, Health Manpower Development Plan (HMDP) Leadership Award FY2024 – UCLA-NUS Executive MBA (2024 to 2025)

Research Interests

Molecular pathology test development for paediatric cancers
BCOR-altered malignancies

Publications

Perlman EJ, Webster F, Chang KTE, Coulomb A, Galluzzo L, Graf NS, Mullen EA, Okita H, O'Sullivan MJ, Somers GR, Treece A, Cohen M, Reyes-Mugica M. Data set for reporting paediatric renal tumours: recommendations from the international collaboration on cancer reporting (ICCR). Histopathol 87: 183-196, 2025. PMID: 40231423
Aw SJ, Tan EEK, Low SYY, Kuick CH, Goh JY, Chang KTE. CNS embryonal tumour with concomitant novel BRD4::CTRC1 fusion and BCOR internal tandem duplication – evidence for synergism and non-mutually exclusive alterations in CNS embryonal tumours. Acta Neuropathologica Comm 12(1), 33, 2024. PMID: 38409021
Goh JY, Kuick CH, Sugiura M, Aw SJ, Zhao ML, Tang HF, Gunaratne S, Zhu FC, Cai L, Teh BT, Thorner PS, Chang KTE. Paediatric BCOR-associated sarcomas with a novel long spliced internal tandem duplication of BCOR exon 15. J Pathol Clin Res 8(5), 470-480, 2022
Koelsche C, Schrimpf D, Stichel D, Sill M, Sahm F, Reuss DE, Blattner M, Worst B, Heilig C, Beck K, Horak P, Kreutzfeldt S, Pfaff E, Stark S, Johann P, Selt F, Ecker J, Sturm D, Pajtler K, Reinhardt A, Wefers A, Sievers P, Ebrahimi A, Suwala A, Fernández-Klett F, Casalini B, Korshunov A, Hovestadt V, Kommoss F, Kriegsmann M, Schick M, Bewerunge-Hudler M, Milde T, Witt O, Kulozik A, Kool M, Romero-Pérez L, Grünewald T, Kirchner T, Wick W, Platten M, Unterberg A, Uhl M, Abdollahi A, Debus J, Lehner B, Thomas C, Hasselblatt M, Paulus W, Hartmann C, Staszewski O, Prinz M, Hench J, Frank S, Versleijen-Jonkers YMH, Weidema M, Mentzel T, Griewank K, de Alava E, Diaz-Martin J, Idoate MA, Chang KTE, Low S, Cuevas-Bourdier A, Mittelbronn M, Mynarek M, Rutkowski S, Schüller U, Mautner V, Schittenhelm J, Serrano J, Snuderl M, Büttner R, Klingebiel T, Buslei R, Gessler M, Wesseling P, Dinjens W, Brandner S, Jaunmuktane Z, Lyskjær I, Schirmacher P, Stenzinger A, Brors B, Glimm H, Heining C, Tirado O, Sáinz-Jaspeado M, Mora J, Alonso J, del Muro XG, Moran S, Esteller M, Benhamida J, Ladanyi M, Wardelmann E, Antonescu C, Flanagan A, Dirksen U, Hohenberger P, Baumhoer D, Hartmann W, Vokuhl C, Flucke U, Petersen I, Mechtersheimer G, Capper D, Jones D, Fröhling S, Pfister S, von Deimling A. Sarcoma classification by DNA methylation profiling. Nat Commun 12(1), 498, 2021. PMID: 33479225
Zhao ML, Yin MZ, Kuick CH, Chen HY, Aw SJ, Merchant K, Ng EHQ, Gunaratne S, Loh AHP, Gu WZ, Tang HF, Chang KTE. Congenital mesoblastic nephroma is characterized by kinase mutations including EGFR internal tandem duplications, ETV6-NTRK3 fusion, and rare KLHL7-BRAF fusion. Histopathol 77(4), 611-621, 2020. PMID: 32590884
Chang KTE, Tay A, Kuick CH, Chen HY, Algar E, Taubenheim N, Campbell J, Mechinaud F, Campbell M, Super L, Chantranuwat C, Yuen ST, Chan JKC, Chow CW. ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion. Modern Pathol 32, 598-608, 2019. PMID: 30573850
Wong MK, Ng CCY, Kuick CH, Aw SJ, Rajasegaran V, Lim JQ, Sudhanshi J, Loh E, Yin MZ, Ma J, Zhang ZD, Iyer P, Loh AHP, Lian DWQ, Wang S, Goh SGH, Lim TH, Lim AST, Ng T, Goytain A, Loh AHL, Tan PH, Teh BT, Chang KTE. Clear cell sarcomas of kidney are characterized by BCOR gene abnormalities including exon 15 internal tandem duplications and BCOR-CCNB3 gene fusion. Histopathol 72(2), 320-329, 2018. PMID: 28833375
Aw SJ, Chang KTE. Clear cell sarcoma of the kidney. Arch Pathol Lab Medicine 143(8), 1022-1026, 2019. PMID: 30628851
Chang KTE, Keating S, Costa S, Machin G, Kingdom J, Shannon P. Third Trimester Stillbirths: Correlative Neuropathology and Placental Pathology. Pediatr Dev Pathol 14(5), 345-352, 2011. PMID: 21345083
Chang KTE, Taylor GP, Meschino WS, Kantor PF, Cutz E. Mitogenic cardiomyopathy – a lethal neonatal familial dilated cardiomyopathy characterized by myocyte hyperplasia and proliferation. Hum Pathol 41(7), 1002-1008, 2010. PMID: 20303141