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Clin Assoc Prof Tan Woon Hui Natalie

MBBS (Spore), MRCPCH (UK), FAMS

Senior Consultant

KK Women's and Children's Hospital

Specialty: Paediatric Infectious Disease

Conditions Treated by this Doctor:
Bacille Calmette-Guérin (BCG), Chickenpox/Herpes/Measles Treatment and Post-exposure Prophylaxis, Methicillin Resistant Staphylococcus Aureus, Post Vaccination Advice, Pre-adoption Screening, Rabies/Meningococcal Post-exposure Prophylaxis, Travel Vaccines for Your Child, Your Child And Antibiotics.

Clinical Appointments

Senior Consultant Infectious Disease Service KK Women's and Children's Hospital

Profile

Dr Natalie Tan Woon Hui is a senior consultant with the Infectious Disease Service, Department of Paediatrics at KK Women’s and Children’s Hospital, Singapore. She is an Adjunct Assistant Professor at NTU Lee Kong Chian School of Medicine, Duke-NUS Medical School Singapore and Yong Loo Lin School of Medicine, National University of Singapore. She is a member of KK Hospital Infection Control Committee (HICC). She was admitted as a Fellow of the Academy of Medicine, Singapore in 2009. She received the 2010 Singhealth Health Manpower Development Plan (HMDP) Award for training in Infectious Diseases in Immunocompromised Children in BC Children’s Hospital in Vancouver, Canada.

She is a national examiner for paediatrics, and a member of the National Postgraduate Year 1 Assessment Committee (Competency Workgroup). She is also a Clinical Core Faculty Member of the Singhealth’s Residency Programme (Paediatrics). She received the Singapore Health Quality Service Star Award in 2015.

Her research interests include Influenza infections, Adenovirus infections, Enterovirus infections, Melioidosis and infections in immunocompromised children.

Education

MMED Surgery (Singapore) 2004
MRCS (Edinburgh) 2004
MBBS National University of Singapore 1998

Professional Appointments and Committee Memberships

Adjunct Assistant Professor, Duke-NUS Medical School Singapore
Adjunct Assistant Professor, NTU Lee Kong Chian School of Medicine
Adjunct Assistant Professor, Yong Loo Lin School of Medicine, NUS
Senior Consultant, Department of General Surgery, Singapore General Hospital 2016 – Present
Member, Ambulatory surgery centre management committee, SGH 2013 – 2015
Senior Consultant, Infectious Disease Service, Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore. 2017 – Present
Member of the National Postgraduate Year 1 Assessment Committee (Competency Workgroup). 2013 – Present
Clinical Core Faculty Member, Singhealth’s Residency Programme (Paediatrics). 2012 – Present
National examiner for paediatrics. 2011 – Present

Awards

Wong Hock Boon Society Outstanding Research Mentor, 2013
Service with a Heart Award, 2012
8th KKH Scientific Meeting 2015 Outstanding Poster-Clinical Research Award, 2015
Singapore Health Quality Service Award 2015- Star Award, 2015
KKH Service From The Heart Award, 2013
Singapore Health Quality Service Award 2013- Gold Award, 2013
Excellent Service Award 2009 (Gold Award), 2009
Excellent Service Award 2008 (Silver Award), 2008

Research Interests

Cell Biology
Identification of cancer susceptibility genes
Influenza infections
Adenovirus infections
Enterovirus and Parechovirus infections
Melioidosis
Infections in immunocompromised children.

Publications

Quantitative methylation analyses of resection margins predict local recurrences and disease specific deaths in patients with head and neck squamous cell carcinomas. Tan HK, Saulnier P, Auperin A, Lacroix L, Casiraghi O, Janot F, Fouret P, Temam S. Br J Cancer. 2008 Jul 22;99(2):357-63.
Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, in head and neck squamous cell carcinoma. Tan KD, Zhu Y, Tan HK, Rajasegaran V, Aggarwal A, Wu J, Wu HY, Hwang J, Lim DT, Soo KC, Tan P. Genes Chromosomes Cancer. 2008 Apr;47(4):353-62.
Teo FM, Nyo M, Wong AA, Tan NW, Koh MT, Chan YF, Chong CY and Chu J. Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia. Accepted for publication in Scientific Reports on 22 February 2018.
Chong CY, Yung CF, Tan NW, Acharyya S, Thoon KC. Risk factors of ICU or high dependency requirements amongst hospitalized pediatric pertussis cases: A 10 year retrospective series, Singapore. Vaccine 2017; 35 (47): 6422-8.
Seow CW, Logarajah V, Tan NW. Typhoid and Scrub Typhus Coinfection in a Returned Traveler. Glob Pediatr Health 2017; 4: 2333794X17726941.
Seah VXF, Ong RYL, Lim ASY, Chong CY, Tan NW, Thoon KC. Impact of a Carbapenem Antimicrobial Stewardship Program on Patient Outcomes. Antimicrob Agents Chemother 2017; 61(9): e00736-17.
Foo CC, Leow EH, Phua KB, Chong CY, Tan NW. A Case of Kawasaki Disease with Concomitant Leptospirosis. Glob Pediatr Health 2017; 4: 2333794X17721368.
Li J, Chong CY, Tan NW, Yung CF, Tee NW, Thoon KC. Characteristics of Zika virus disease in children: Clinical, hematological and virological findings from an outbreak in Singapore. Clin Infect Dis 2017; 64 (10):1445-8.
Vemula VN, Li L, Thoon KC, Chong CY, Tee NW, Maiwald M, Tan NW. Risk Factors and Clinical Profile of Measles Infection in Children in Singapore. Infection, Disease & Health 2016; 21: 192-6.
Tan JM, Tan NW, Thoon KC, Chong CY, Ong C. Dengue Fever Associated Liver Failure. Pediatric Infect Dis 2016; 1:31.
Yung CF, Chong CY, Yeo KT, Liew C, Ng LC, Tan NW, Yeo GSh, Tee NW, Lin RT, Tan TC, Rajadurai VS, Chan JK, Thoon KC. Zika Virus: An Evolving Public Health Threat. Ann Acad Med Singapore 2016; 45(4):148-51.
Tan LO, Thoon KC, Chong CY, Tan NW. Rhabdomyolysis Caused by Rhinovirus. Glob Pediatr Health 2016; 3:2333794X16643726.
Ahmad Hatib NA, Chong CY, Thoon KC, Tee NW, Krishnamoorthy SS, Tan NW. Enteric Fever in a Tertiary Paediatric Hospital: A Retrospective Six-Year Review. Ann Acad Med Singapore 2016; 45(7): 297-302.
Lam JC, Chai JY, Wong YL, Tan NW, Ha C, Chan MY, Tan AM. Causative Pathogens of Febrile Neutropaenia in Children Treated for Acute Lymphoblastic Leukaemia. Ann Acad Med Singapore 2015; 44(11):530-4.
Chong CY, Tan NW, Yunos H, Lim SH, Acharyya S, Thoon KC. Temporal trend in the incidence of pertussis and exposures among healthcare workers: descriptive report from a tertiary care hospital for children in Singapore. J Hosp Infect. 2015; 91(4):376-8.
Tan NW, Lee EY, Khoo GM, Tee NW, Krishnamoorthy S, Choong CT. Cerebrospinal Fluid White Cell Count: Discriminatory or Otherwise for Enteroviral Meningitis in Infants and Young Children? J Neurovirol. 2016 22(2):213-7.
Wee LY, Tanugroho RR, Thoon KC, Chong CY, Choong CT, Krishnamoorthy S, Maiwald M, Tee NW, Tan NW. A 15-year retrospective analysis of prognostic factors in childhood bacterial meningitis. Acta Paediatr. 2016; 105 (1):e22-9.
Krishnan SG, Tee NW, Tan AL, Tan AM, Koh MJ, Chong CY, Thoon KC, Tan NW. A Case of Cutaneous Penicilliosis in a child with Acute Myeloid Leukemia. JMM Case Reports 2015 2. doi: 10.1099/jmmcr.0.000098.
Lee EY, Oh JY, Chong CY, Choo JT, Mahadev A, Tan NW.A Case of Atypical Kawasaki Disease With Myositis. Glob Pediatr Health 2015; 2: 2333794X15599649.
Ang SH, Huang SW, Tan AL, Tee NW, Tan NW. An Alternative Diagnosis: Bartonella Neuroretinitis. Ann Acad Med Singapore 2015; 44(6): 229.
Seah VX, Ngeow AJ, Thoon KC, Tee NW, Maiwald M, Chong CY, Tan NW. Infant with invasive nontyphoidal salmonellosis and mastitis. Glob Pediatr Health 2015; 2:2333794X15591568.
Ng OT, Thoon KC, Chua HY, Tan NW, Chong CY, Tee NW, Lin RT, Cui L, Venkatachalam I, Tambyah PA, Chew J, Fong RK, Oh HM, Krishnan PU, Lee VJ, Tan BH, Ng SH, Ting PJ, Maurer-Stroh S, Gunalan V, Khong WX. Severe Pediatric Adenovirus 7 Disease in Singapore Linked to Recent Outbreaks across Asia. Emerg Infect Dis. 2015; 21(7): 1192-6.
Prerna A, Lim JY, Tan NW, Isa MS, Oh HM, Yassin N, Low CY, Chan DW, Chong CY, Leo YS, Chow AL, Tambyah PA, Tan K. Neurology of the H1N1 pandemic in Singapore: a nationwide case series of children and adults. J Neurovirol. 2015; 21(5): 491-9.
Foong YW, Tan NW, Chong CY, Thoon KC, Tee NW, Koh MJ. Melioidosis in children: a retrospective study. Int J Dermatol 2015; 54(8):929-38.
Rajkumar V, Chiang CS, Low JM, Cui L, Lin RT, Tee NW, Maiwald M, Chong CY, Thoon KC, Tan NW. Risk factors for severe adenovirus infection in children during an outbreak in Singapore. Ann Acad Med Singapore 2015; 44(2):50-9.
Seah XF, Ong YL, Tan SW, Krishnaswamy G, Chong CY, Tan NW, Thoon KC. Impact of an Antimicrobial Stewardship Program on the Use of Carbapenems in a Tertiary Women's and Children's Hospital, Singapore. Pharmacotherapy 2014; 34(11):1141-50.
Soh SB, Han PY, Tam KT, Yung CF, Liew WK, Tan NW, Chong CY, Thoon KC. Investigations into an outbreak of suppurative lymphadenitis with BCG vaccine SSI® in Singapore. Vaccine 2014; 32(44):5809-15.
Thoon KC, Soh SB, Liew WK, Gunachandran A, Tan NW, Chong CY, Yung CF. Active surveillance of adverse events following childhood immunization in Singapore. Vaccine 2014; 32(39):5000-5.
Chong CY, Tan NW, Menon A, Thoon KC, Tee NW, Fu S. Risk Factors for Complicated Influenza A (H1N1) 2009 Disease in Children. Ann Acad Med Singapore 2013; 42:232-6.
Tan NW, Turvey SE, Byrne AT, Ludemann JP, Kollmann TR. Staphylococcus aureus nasal septal abscess complicated by extradural abscess in an infant. J Otolaryngol Head Neck Surg 2012; 41(1):E7-E12.
Tan NW, et al. Hib-DTaP-poliovirus vaccine. Abscess in infants: 7 case reports. Reactions 2010; 1317:27.
Tan NW, Pan WJ, Yunos HHBM, Tan WC and Lim KBL. Post-vaccination abscesses requiring surgical drainage in a tertiary children’s hospital in Singapore. J Pediatr Infect Dis 2010; 5:139-147.
Tan NW, Sriram B, Tan-Kendrick AP, Rajadurai VS. Neonatal hepatic abscess in preterm infants: A rare entity? Ann Acad Med Singapore 2005; 34:558-64.
Lee TW, Khor WB, Tan NW, Cheng CL, Seow A, Foo SC. A cross-sectional survey of physical activity among middle aged women in Singapore. Singapore Med J 1999; 40:468-76.

Research Trials

Antimicrobial Stewardship Program bridging Grant (MOH), 2016-2018
National Antimicrobial Taskforce, Antimicrobial Stewardship Program Grant (MOH), 2011-2015
Molecular integrated clinical epidemiology paediatric dengue prospective study (MICE-PD) (SingHealth Foundation Research Grant 2015), 2016-
Virological, molecular epidemiological surveillance and biomarker discovery of human enteroviruses in children with hand, foot and mouth disease in Singapore (NMRC Grant) 2013-