Profile
Dr Prasad Iyer is a Senior Consultant from the Children's Cancer Centre, at KK Women's and Children's Hospital, Singapore.
After exiting paediatric residency training from India, he spent nearly a decade and a half training and working in the best paediatric centres in the United Kingdom. He completed his advanced specialist training and obtained the Certificate of Completion of Training from Manchester. He then worked in paediatric/adolescent oncology and haematopoietic stem cell transplantation at The Great North Children’s Hospital (Royal Victoria Infirmary) Newcastle (UK) and was awarded the Fellowship of the Royal College of Paediatrics and Child Health. He considers it his great privilege that he was able to train and work with world experts in oncology and haematopoietic stem cell transplantation in Manchester and Newcastle.
Whilst he enjoys general paediatric oncology, he has a keen interest in acute leukaemia, bone marrow transplantation and cellular therapies. He is a passionate teacher and a teaching faculty in all three medical schools in Singapore and also has an active interest in clinical research.
Education
- MBBS (India) 1998
- MD (Paediatrics) 2002
- DCH (UK) 2004
- MRCPCH (UK) 2004
- FRCPCH (UK) 2012
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Professional Appointments and Committee Memberships
- Adjunct Assistant Professor Duke-NUS Graduate Medical School
- Adjunct Assistant Professor Lee Kong Chian School of Medicine
- Clinical Senior Lecturer, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore (NUS)
- Physician faculty, SingHealth Residency
- Treasurer, Paediatric Oncology Group Singapore
- Leukaemia study group chairman: Paediatric Oncology Group, Singapore (POGS)
- Member, Viva-Asia BMT consortium
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Awards
- Silver Award for Singapore Health Quality Service Award 2018.
- SingHealth Service from the Heart award (July-December 2018)
- Dr Arvinda Nanalal Chokshi Gold Medal, Outstanding performance (MD Paediatrics) Maharaja Sayajirao University of Baroda, India, 2001
- Dr Narayan S Desai Gold Medal, Best candidate (MD Paediatrics), Maharaja Sayajirao University of Baroda, India, 2001
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Research Interests
- Acute leukaemia
- Haematopoietic stem cell transplantation and immunotherapies
- Early phase oncology trials
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Publications
- The interplay between coagulation and inflammation pathways in COVID-19-associated respiratory failure: a narrative review. Pulmonary therapy. 2020 Aug 25:1-7. Bhattacharyya R, Iyer P, Phua GC, Lee JH.
- Neuroblastoma patient‐derived cultures are enriched for a mesenchymal gene signature and reflect individual drug response. Cancer science. 2020 Oct; 111(10):3780. Hee E, Wong MK, Tan SH, Choo ZE, Kuick CH, Ling S, Yong MH, Jain S, Lian DW, Ng EH, Yong YF, Ren MH, Sulaiman NS, Low SYY, Chua YW, Syed MF, Lim TKH, Soh SY, Iyer P, Seng MSF, Lam JCM, Tan EEK, Chan MY, Tan AM, Chen Y, Chen Z, Chang KTE, Loh AHP.
- Profound hyperferritinemia may not be specific for the diagnosis of haemophagocytic lymphohistiocytosis (HLH) in Asian children. Pediatric Hematology Oncology Journal. 2020 Sep 1; 5(3):96-9. Cher WQ, Kalyanasundaram R, Chan MY, Ho CK, Iyer P*, Bhattacharyya R*.
- Larotrectinib followed by selitrectinib in a novel DCTN1–NTRK1 fusion undifferentiated pleomorphic sarcoma. Journal of Oncology Pharmacy Practice. 2020 Jul 21. Goh XN, Seng MS, Loh AH, Gupta A, Chang KT, Iyer P.
- Clinical relevance of screening checklists for detecting cancer predisposition syndromes in Asian childhood tumours. NPJ Genomic Medicine 2018 Nov 15; 3(1): 30. Chan SH, Chew W, Ishak NDB, Lim WK, Li ST, Tan SH, Teo JX, Shaw T, Chang K, Chen Y, Iyer P, Tan EEK, Seng MS, Chan MY, Tan AM, Low SYY, Loh AHP, Ngeow J.
- Primary bone anaplastic large cell lymphoma masquerading as Ewing sarcoma - diagnosis by Anchored Multiplex PCR. Journal of Pediatric Hematology/Oncology. 2018 Mar 1; 40(2): e103-7. Hue SS*, Iyer P*, Toh LWH, Jain S, Tan EEK, Sittampalam K, Chang KTE:
- An Unusual Cause of Fever and Rash in a Child with Severe Aplastic Anemia. Journal of Pediatric Hematology/Oncology. 2018 Mar; 1, 40(2): 156-8. Lee EY, Lian WQ, Iyer P, Bhattacharyya R.
- Clear cell sarcomas of kidney are characterized by BCOR gene abnormalities including exon 15 internal tandem duplications and BCOR-CCNB3 gene fusion. Histopathology. 2018 Jan; 72(2): 320-9.
Wong MK, Ng CCY, Kuick CH, Aw SJ, Rajasegaran V, Lim JQ, Jain S, Loh E, Lian DWQ, Yin M, Ma J, Zhang Z, Iyer P, Loh AHP, Wang S, Goh SGH, Lim TH, Lim AST, Chang KTE.
- Chew WHW, Courtney E, Lim KH, Li ST, Chen Y, Ran MH, Chung A, Khoo J, Loh A, Soh SY, Iyer P, Loh LM, Ngeow J. Clinical management of pheochromocytoma and paraganglioma in Singapore: missed opportunities for genetic testing. Molecular genetics & genomic medicine. 2017 Sep; 5(5): 602-7
- CD3 depleted haploidentical stem cell transplant in paediatric acute undifferentiated leukaemia. Pediatric Hematology Oncology Journal. 2017 Mar 1; 2(1): 12-3. Iyer P, Seng MS, Vijayakumari K, Bhattacharyya R.
- Successful treatment of cardiac juvenile xanthogranuloma in an infant with LCH chemotherapy. Pediatric Hematology Oncology Journal, 2016 Oct 1; 1(4): 93-5. Seng MS, Choo JTL, Leong MY, Fortier M, Iyer P.
- TCR αβ and CD19-depleted haploidentical stem cell transplant with reduced intensity conditioning for Hoyeraal-Hreidarsson syndrome with RTEL1 mutation. Bone Marrow Transplant, 2016. 51, 753-754. Bhattacharyya R, Tan AM, Chan MY, Jamuar SS, Foo R and Iyer P (2016).
- Utility of echocardiography in identifying right ventricular extension of Wilm's tumor. Journal of Clinical Ultrasound. 2015 May; 43(4): 262-4. Iyer P, Sibal N, Chaudhari M, Wood KM, Campbell-Hewson Q.
- Should initial investigations for neoplastic causes of precocious puberty include serum beta-human chorionic gonadotropin and alpha-fetoprotein? Pediatr. Blood Cancer, 2015 Mar 62(3): 545. Iyer P, Rajasekaran V and Lek, N. (2015).
- Congenital GATA1-mutated myeloproliferative disorder in trisomy 21 complicated by placental fetal thrombotic vasculopathy. Hum Pathol. 2014 Nov 1; 45(11): 2364-7. Loh TJZ, Lian DWQ, Iyer P, Lam JCM, Kuick CH, Aung ACL, Chang KTE. (2014).
- Incidence and outcome of pancreatitis in children and young adults with acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003. British journal of haematology. 2013 Sep; 162(5): 710-3. Samarasinghe S, Dhir S, Slack J, Iyer P, Wade R, Clack R, Vora A, Goulden N.
- Pediatric chronic myeloid leukemia with B-cell lymphoid blast crisis at presentation. Blood Res. 2013 Jun 1; 48:151-2. Iyer P, Carey P, Bown N, Samarasinghe S.
- Severe feeding difficulties in 3C syndrome. Clinical dysmorphology. 2005 Apr 1; 14(2): 101-3. Iyer P, Smith R.
- Book chapters:
- Iyer P. Investigating and managing children with recurrent abdominal pain. In: Shendurnikar N, Agrawal M, editors: Trends in Clinical Pediatrics. 1st ed: Delhi: Academa; 2006.
- Iyer P and Chan MY. Lymphadenopathy. In: Soh SY, Jamuar S, Puthucheary J, editors: The baby bear book: a practical guide on paediatrics. 3rd ed: Singapore; Red cell series; 2015.
- Iyer P. Curing Childhood Cancer: Are we there yet? In Tan TC, Goh A, Lim S, editors: Special delivery. Singapore; KK Women’s and Children’s Hospital; Volume 65: Issue 01. 2016: 8-9.
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Research Trials
- SIOP-Renal tumour study group (RTSG) 2016 Umbrella – International multi-centre study on kidney tumours: site Principal investigator (Singapore). Principal investigator: Prof Norbert Graf.
- Paediatric Hepatic International Tumour Trial (PHITT): International multi-centre study on liver tumours. Co-investigator: Site principal investigator: Dr Soh Shui Yen.
- Bayer 20810 - A Phase 1/2 Study of the TRK Inhibitor Selitrectinib (BAY 2731954) in Adult and Pediatric Subjects with Previously Treated NTRK Fusion Cancers: Site Principal Investigator. Principal investigator: Dr Daniel Tan
- Modeling, Analysis and Translational Therapeutics for Tumors of Childhood (MAT3CH). Co-investigator: Principal investigator: Dr Amos Loh.
- Singapore-Malaysia Acute Lymphoblastic Leukaemia (ALL) Ma-Spore ALL- Seq 2020. Co-investigator: Principal investigator: Prof Allen Yeoh.
- Malaysia-Singapore Childhood Acute Myeloid Leukaemia Study 2006. Co-investigator: Principal investigator: Prof Allen Yeoh.
- Singapore-Malaysia Acute Lymphoblastic Leukaemia (ALL) Treatment Protocol – A Risk-Stratified Study Using Primarily the Early Response to Therapy as the Risk Stratification Criteria, Incorporating Pharmacogenetics, Gene Expression Profiling, Proteomics and Cell Banking (Ma-Spore ALL 2003 Study): Co-investigator: Principal investigator: Prof Allen Yeoh.
- Singapore-Malaysia Acute Lymphoblastic Leukaemia (ALL) Treatment Protocol Ma-Spore 2010. Co-investigator: Principal investigator: Prof Allen Yeoh.
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