Clin Assoc Prof Chao Sing Ming

Clinical Assoc Prof Chao Sing Ming is a senior consultant in Paediatric Nephrology, A/P Chao headed the Nephrology Service from 2002 to 2012.

A past ASEAN scholar, she was trained in paediatric nephrology under HMDP fellowship at Royal Children’s Hospital Melbourne and Royal Melbourne Hospital. During her headship, she successfully set up a multi-disciplinary Voiding problem clinic and laid the foundation for development of Paediatric Nephrology Service at KK Women's and Children's Hospital.

She enjoys teaching undergraduate students, postgraduate students and young doctors undergoing Paediatric training, as Associate Professor at NUS-YLL School of medicine, Duke-NUS Graduate Medical School and Paediatric Academic Clinical Programme.

She is actively involved in research as the Principal Investigator, Co-investigator in research projects and clinical trials including NMRC grant projects. She had also participated actively in International and National scientific conferences in her capacity as organizing chair, invited speaker and symposium chair.

In 2016 she was awarded the best oral presentation on her research work at the 17^th Congress of International Paediatric Nephrology Association. She had numerous publications in peer- reviewed international journals and had authored book chapters on Paediatric Nephrology.

She served as a past member of the National Advisory Committee on Renal Care and was responsible for the Ministry of Health Clinical Practice Guidelines for Treatment of childhood UTI as well as Voiding Dysfunction in children. She has served as reviewer in national medical research projects and peered review journals.

• Fellow, Royal Children’s Hospital, renal service (1991-1992).
• Honorary Scholar, Renal Department, Royal Melbourne Hospital, (1991-1992)
• Fellow (Honorary Life Member) Academy of Medicine Singapore
• MMed PAEDS (Singapore) 1982
• MBBS National University of Singapore 1977

• Senior Consultant, Department of Paediatric Medicine, Nephrology Service, Head (2002-2012), Senior consultant (1997-present)
• Member, Ministry of Health Advisory Committee on National Renal Care (2003-2008)
• Visiting Senior Consultant, Dept of Paediatrics (Nephrology) National University Hospital (1992-2023)
• Mentor, NMRC project (2013 -2016)
• Complaints committee, Singapore Medical Council (2012-2017)                                                                                 
• SMC expert medical witness (2015)
• Adjunct Associate Professor, Yong Loo Lin School of Medicine, NUS
• Clinical Associate Professor, Duke-NUS Graduate medical School
• Reviewer, Singapore Medical Journal.                                                     
• Reviewer, Annals Academy of medicine Singapore
• Reviewer, NMRC grants

• Best Oral Presentation, 17th Congress of International Paediatric Nephrology Association 2016
• National Day Long Service Award (2011)
• Outstanding Reviewer Award, Singapore Medical Journal (2023)
• EXSA award Gold (2006)
• KK Women's and Children's Hospital Service from the Heart (2003, 2004, 2005)
• HMDP fellowship (1991-1992)
• ASEAN Scholarship

• PI:  Translational research Grant 09-025 (MNRC) on Genetics of Innate Immunity, Host
  Susceptibility and Genetics of Bacterial Virulence in childhood UTI (2012-2017)
•  Co-I: Next Generation Sequencing and Mechanistic Understanding for the Diagnosis and Management of Primary Glomerular Disease in Singapore. (2014-2019)
• Co-I: Renal Alliance for Precision Diagnosis in Singapore (RAPIDS) study/programme -ongoing
• PI-site: Phase III multicenter, open label study to evaluate long-term safety and tolerability of Valsartan in children with hypertension with or without chronic renal failure. (2010-2012)
• PI-site: Phase III prospective, randomized, double-blind, placebo-controlled multicenter study on pharmacokinetics, safety and efficacy of Paricalcitol in Pediatric Chronic Renal Failure. (AbbVie 2008-2010)
• PI-site: Clinical Phase III multicenter, double blind, randomized, placebo-controlled trial on the efficacy, pharmacokinetics and safety of Alfuzocin 0.2mg/kg/day in the treatment of Neuropathic bladder with hydronephrosis. (Sanofi 2008-2010)
• PI-site:  Clinical Phase III multicenter, double blind, randomized, placebo-controlled trial on safety and efficacy of Alfuzocin in 2 doses in the treatment of neuropathic bladder (Sanofi 1998-1999)
• PI: Randomized placebo-controlled Double-blind cross-over clinical study on the safety and efficacy of oral DDAVP in Singapore Children with Primary Nocturnal Enuresis. (1998-2000) Grant from Ferrings Pharmaceuticals.
• PI: DMSA scan in childhood UTI and correlation to VUR (1998-1999) IAEA grant

• A bacterial protease depletes c-MYC and increases survival in mouse models of bladder and colon cancer.   
  Daniel S. C. Butler, Caterina Cafaro1, Johannes Putze, Murphy Lam Yim Wan, Thi Hien Tran, Ines Ambite, Shahram Ahmadi, Sven Kjellström, Charlotte Welinder, Sing Ming Chao, Ulrich Dobrindt and Catharina Svanborg. Nature Biotechnology (Feb 2021); 39, 754-764  JIF: 54.908
• Molecular determinants of disease severity in urinary tract infection.
  Ines Ambite, Daniel Butler, Murphy Lam Yim Wan, Therese Rosenblad, Thi Hien Tran, Sing Ming Chao and Catharina Svanborg.
  Nature reviews urology (Jun 2021). 18: 468-486  JIF: 14.43
• Molecular analysis of acute pyelonephritis—excessive innate and attenuated adaptive immunity.
  Ines Ambite, *, Sing Ming Chao, * Therese Rosenblad, *, Richard Hopkins, Petter Storm, Yong Hong Ng, Indra Ganesan, Magnus Lind´en, Farhan Haq, Thi Hien Tran, Shahram Ahmadi, Bernett Lee, Swaine L Chen, Gabriela Godaly, Per Brandstr ¨om, John E Connolly, Catharina Svanborg. (* I Ambite, SM Chao, and T Rosenblad are joint first authors)
  Life-Science-Alliance (March,2025 vol 8 (3) 1-16  JIF:3.5
• Analysis of the Innate Immune Response to Febrile UTI in Infants: Evidence of an Acute Cytokine Storm.
  Ahmadi, S., Rosenblad, T., Sabari, S., Linden, M., Brandström, P., Chao, S. M., Svanborg, C., & Ambite, I.  Pediatr Infect Dis J (Dec 2025)1;44(12):1188-1200  JIF : 4.3
• Clinical implication of nephrologist-led genomic testing for Genetic Diseases in Singapore: rationale and protocol
  Lim C, Lim RS, Choo J, Leow EH, Chan GC, Zhang Y, Ng JL, Chin HL, Tan ES, Goh J, Gandhi N, Ng YH, Tham M, Ganesan I, Chong SL, Yap C, Chao SM, Cham B, Kam S, Lim JY, Mok I, Tan HZ, Kwek JL, Lee TL, Wang Z, Goh SM, Lim R, Yeo SC, Teo BW, DA Y, Matchar D, Ng KH.
  Am J of Nephrol (Apr 2025) 52(2): 158-171  JIF: 3.2
• A novel GATAD2B frameshift variant causes GATAD2B-associated neurodevelopmental disorder with camptodactyly
• Cheryl Weiqi Tan; Jiin Ying Lim; Khadijah Rafi’ee; Jeannette Goh; Chew Thye Choong; Sing Ming Chao; Benjamin Chang; Saumya S. Jamuar; Ene-Choo Tan.
  Mol Syndromol (Apr 2025) 2:1-5   JIF:1.5
• Multicenter study on the genetics of glomerular diseases among southeast and south Asians: Deciphering Diversities - Renal Asian Genetics Network (DRAGoN)
  Liangjian Lu,Yok-Chin Yap, Duc Quang Nguyen, Yiong-Huak Chan, Jun-Li Ng1, Yao-Chun Zhang, Chang-Yien Chan1, Mya Than1, Isaac Desheng Liu, Sadaf Asim, Khemchand Moorani, Bilquis Naeem, Iftikhar Ijaz, Thi Minh Tan Nguyen, Ming-Lee Lee, Caroline Eng, Syed Saimul Huque, Yong-Hong Ng, Indra Ganesan, Sing-Ming Chao, Siew-Le Chong, Puay-Hoon Tan, Alwin Loh, Sonia Davila, Vikrant Kumar, Joanna Zhi-Jie Ling, Rajesh Babu Moorakonda, Karen Mei-Ling Tan, Alvin Yu-Jin Ng, Kok-Siong Poon, Franz Schaefer, Beata Lipska-Zietkiewicz, Hui-Kim Yap, Kar-Hui Ng. Clinical Genetics (Jan 2022); 1-11.  JIF: 2.3
• Adenine phosphoribosyltransferase (APRT) deficiency: an increasingly recognized disease.
  Leow, E. H., Ganesan, I., Chong, S. L., Yap, C. J. Y., Chao, S. M., Wang, F., & Ng, Y. H. .
  Int Urol Nephrol (Aug 2025); 57(8):2519-2529 JIF 1.9
• IgA nephropathy in children: before and after the start of COVID -19
  Esther H Liew, SL Chong, Celeste JY Yap, Sing Ming Chao, I Ganesan, F Wan, YH Ng
  Pediatric Nephrology (2024) Vol 39 pages 1161-1167  JIF:2.6
• Renal toxicity presenting with a fracture in a HIV positive Adolescent. LY Justin Wee, KC Thoon, SM Chao J Pediatr Infect Dis 2018;13:81–83.
• Renal Biopsy and Renal Pathology. SM Chao, PH Tan, G Chiang Practical Paediatric Nephrology : An update of current practices (Medcom 2005). Chapter 5 Enuresis and Voiding Dysfunction in Children. SM Chao. Practical Paediatric Nephrology (Medcom, 2005), Chapter 20
• Efficacy and safety of once daily Gentamicin in Childhood UTI .CY Chong, ASL Tan, APA Tan Kendrick, SM Chao. Acta Paediatrica 2003(92)1-6.
• Primary Monosymptomatic Nocturnal Enuresis – Parental perspectives in an Asian Community SM Chao, A Tan, HK Yap, EK Ong, EH Low et al. Ann Acad Med Singapore, 1997 (26):179-18.
• Efficacy and Safety of DDAVP in the treatment of nocturnal, Enuresis in an Asian Community. HK Yap, SM Chao, B Murugasu et al. J paediatr, Child Health. 1998 (34)151-153
• Efficacy and Safety of One Year Growth Hormone Therapy in Steroid Dependent Nephrotic syndrome. KY Loke, HK Yap, Xin Zhou, SM Chao, KO Lee et al 1997 J Paed 39:793-9
• Phaeochromocytoma – A Rare Cause of Hypertension in an 11 year old Girl. Rajalingam, SM Chao. Ann Acad med Singapore 1996;25:58
• Triple Immunosuppresive Regime and Prednisolone Withdrawal in Paediatric Renal Transplantation, 1993
• Perineal eruption as an early sign of Kawasaki Disease Annal Singapore 1991
• Vesicoureteric Reflux and Renal Scarring in Children – A Local Perspective, Singapore Medical Journal 1991
• Comparison of progression of Renal Failure in Children with Hypoplastic-Dysplastic Kidneys and Chronic Glomerulonephritis, Singapore medical Journal 1991