Conditions and Treatments | KK Women's and Children's Hospital

Clinical Research:

Paediatric Hepatic International Tumour Trial (PHITT)
Site Principal Investigator: Dr. Soh Shui Yen
SIOP Renal Tumour Study Group (RTSG) (UMBRELLA Protocol)
Site Principal Investigator: Dr. Prasad Iyer
DAY101 in Paediatric and Young Adult Patients With Relapsed or Progressive Low-Grade Glioma and Advanced Solid Tumours (FIREFLY-1)
(ClinicalTrials.gov Identifier: NCT04775485)
Site Principal Investigator: Dr. Enrica Tan
DAY101 vs. Standard of Care Chemotherapy in Pediatric Patients With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)
(ClinicalTrials.gov Identifier: NCT05566795)
Site Principal Investigator: Dr. Enrica Tan
Repotrectinib in Paediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations
(ClinicalTrials.gov Identifier: NCT04094610)
Site Principal Investigator: Dr. Soh Shui Yen
Comprehensive Genomic Profiling of Paediatric Brain and Solid Tumours (SPONC18B1)
Site Principal Investigator: Dr. Mya Soe Nwe
Phase I/II multicenter study to assess efficacy and safety of ribociclib (LEE011) in combination with topotecan and temozolomide (TOTEM) in paediatric patients with relapsed or refractory neuroblastoma and other solid tumours
(ClinicalTrials.gov Identifier: NCT05429502)
Site Principal Investigator: Dr. Soh Shui Yen

CD19-Directed Chimeric Antigen Receptor (CAR) T-Cell Therapy (SHCELL18P1)
(ClinicalTrials.gov Identifier: NCT05648019)
Principal Investigator: Dr. Soh Shui Yen
Dual Anti-CD22/CD19 Chimeric Antigen Receptor-directed T-cell Therapy
(ClinicalTrials.gov Identifier: NCT05429905)
Principal Investigator: Dr. Michaela Seng
Novel Adoptive Cellular Therapy with SARS-CoV-2 Specific T cells in Patients with Severe COVID-19
(ClinicalTrials.gov Identifier: NCT04351659)
Principal Investigator: Dr. Michaela Seng

Malaysia – Singapore Acute Lymphoblastic Leukaemia – Seq 2020
(ClinicalTrials.gov Identifier: pending)
Site Principal Investigator: A/Prof. Tan Ah Moy
Asia Down Syndrome – Acute Lymphoblastic Leukaemia (DS-ALL) 2016
(ClinicalTrials.gov Identifier: NCT03286634)
Site Principal Investigator: A/Prof. Tan Ah Moy
Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory ALL
(ClinicalTrials.gov Identifier: NCT02303821)
Site Principal Investigator: Dr. Prasad Iyer
BH3 Profiling on ALL and AML Blasts to Direct Leukemia and Lymphoma Treatment
Site Principal Investigator: Dr. Prasad Iyer

PEGylated Recombinant Factor VIII (BAX855) in Previously Untreated Patients (PUP) With Severe Haemophilia A
(ClinicalTrials.gov Identifier: NCT02615691)
Principal Investigator: Dr. Joyce Lam
MUSFIH-PRO
Principal Investigator: Dr. Joyce Lam

Hokusai Study in Pediatric Patients With Confirmed Venous Thromboembolism (VTE)
(ClinicalTrials.gov Identifier: NCT02798471)
Site Principal Investigator: Dr. Joyce Lam
Asian-Pacific Microangiopathic Thrombocytopenia (APMAT) Network
Site Principal Investigator: Dr. Joyce Lam
International Epidemiological Study of Neonatal Purpura Fulminans
Site Principal Investigator: Dr. Joyce Lam
International Paediatric Thrombosis Network
Site Principal Investigator: Dr. Joyce Lam

The research arm of the Children's Cancer Foundation (CCF) Psychosocial Supportive Care Programme (PSCP) aims to explore and develop innovative interventions to address the psychosocial needs of children with cancer and their families in Singapore. Our ongoing research ensures that our support services are up-to-date with the best clinical practices, so that our patients and families receive the best possible care.

Basic and translational research:

Brain and Solid Tumour (BST)

Blood and Marrow Transplant and Cellular Therapy (BMTCT)

Our Research

Clinical Research: