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Clin Assoc Prof Chao Sing Ming

MBBS, MMed (Paediatrics), FAMS

Senior Consultant

KK Women's and Children's Hospital

Specialty: Paediatric Nephrology

Conditions Treated by this Doctor:
Bedwetting, Congenital Anomalies of the Kidney and Urinary Tract (CAKUT), Fluid and Electrolyte Problems including Tubulopathies, Glomerulonephritis and Glomerular Diseases including Nephrotic Syndrome, Microhaematuria and Proteinuria, Hypertension, Hypertension, Imaging Tests for Urinary Tract Infections (Children), Kidney Biopsy in Children, Kidney Swelling (Hydronephrosis), Nephrotic Syndrome (Children), Reflux Nephropathy, Renal Failure, Urinary Tract Infection (Child), Vesicoureteric Reflux, Voiding Dysfunction including Bedwetting/Nocturnal Enuresis.

Clinical Appointments

Senior Consultant Nephrology Service (Kidney Diseases) KK Women's and Children's Hospital
Department of Paediatrics, National University Hospital

Profile

A senior consultant paediatrician since 1997, Adj Assoc Prof Chao Sing Ming headed the Nephrology Service from 2002 to 2012.

A former ASEAN scholar, she was also trained as a paediatric nephrologist under the HMDP fellowship at Royal Children’s Hospital and Royal Melbourne Hospital during 1991-1992. She is actively involved in undergraduate and postgraduate teaching and is the Principal Investigator in numerous research projects and clinical studies. She had also participated actively in International, Regional and National scientific meetings in her capacity as invited speaker, symposia chair and organizing chair. She had numerous publications in peer- reviewed journals and had written book chapters on Paediatric Nephrology. She is a member of the National Advisory Committee on Renal Care and was responsible for the Ministry of Health Clinical Practice Guidelines for Treatment of childhood UTI as well as Voiding Dysfunction in children. She has also been regularly invited to review national medical research projects and journal articles.

Adj Assoc Prof Chao’s subspecialty interests include Childhood UrinaryTract Infection, Voiding Dysfunction, Nephrotic Syndrome, Childhood Lupus Nephritis and other general renal problems in children.

Education

MBBS, University of Singapore (1977)
Master of Medicine (Paediatrics), National University of Singapore (1982)
Fellow, Academy of Medicine (Singapore) (1991)

Professional Appointments and Committee Memberships

Senior Consultant, Department of Paediatric Medicine, Nephrology Service, KKH
Visiting Senior Consultant, Department of Paediatrics (Nephrology) National University Hospital
Adjunct Associate Professor, Yong Loo Lin School of Medicine, NUS
Adjunct Associate Professor, Duke-NUS Graduate School of Medicine
Reviewer, National NMRC projects, Singapore Medical Journal, Annals Academy of medicine Singapore
Teaching faculty, Residency Programme for Paediatric Medicine
Teaching faculty, Master of Medicine in Paediatrics and Family Medicine
Editorial Board, Singapore Society of Continence
Member, International Paediatric Nephrology Association
Member, Ministry of Health Advisory Committee on National Renal Care
Fellow, Academy of Medicine, Singapore

Awards

Best Oral Presentation, Congress of 17th International Pediatric Nephrology Association 2016.
National Day Long Service Award ( 2009)
EXSA award Gold (2006)
KK Women's and Children's Hospital Service from the Heart (2003, 2004, 2005)
HMDP fellowship for paediatric nephrology as clinical fellow at Royal Children’s Hospital, Melbourne and Visiting Associate, Nephrology Department, Royal Melbourne Hospital
ASEAN Scholarship

Research Interests

Childhood Urinary Tract Infection and Reflux Nephropathy
Enuresis and Voiding Dysfunction in Children
Childhood Lupus Nephritis

Publications

Renal toxicity presenting with a fracture in a HIV positive Adolescent. LY Justin Wee, KC Thoon, SM Chao J Pediatr Infect Dis 2018;13:81–83.
Can Urinary Proteome be used as early Non-invasive Marker and Outcome Predictor of Febrile UTI? SM Chao, J Connolly, YH Ng, I Ganasen et al. Pediatr Nephrol 2016, 31:1746
Renal Biopsy and Renal Pathology. SM Chao, PH Tan, G Chiang Practical Paediatric Nephrology : An update of current practices (Medcom 2005). Chapter 5 Enuresis and Voiding Dysfunction in Children. SM Chao. Practical Paediatric Nephrology (Medcom, 2005), Chapter 20
Efficacy and safety of once daily Gentamicin in Childhood UTI .CY Chong, ASL Tan, APA Tan Kendrick, SM Chao. Acta Paediatrica 2003(92)1-6.
Primary Monosymptomatic Nocturnal Enuresis – Parental perspectives in an Asian Community SM Chao, A Tan, HK Yap, EK Ong, EH Low et al. Ann Acad Med Singapore, 1997 (26):179-18.
Efficacy and Safety of DDAVP in the treatment of nocturnal, Enuresis in an Asian Community. HK Yap, SM Chao, B Murugasu et al. J paediatr, Child Health. 1998 (34)151-153
Efficacy and Safety of One Year Growth Hormone Therapy in Steroid Dependent Nephrotic syndrome. KY Loke, HK Yap, Xin Zhou, SM Chao, KO Lee et al 1997 J Paed 39:793-9
Phaeochromocytoma – A Rare Cause of Hypertension in an 11 year old Girl. Rajalingam, SM Chao. Ann Acad med Singapore 1996;25:58
Triple Immunosuppresive Regime and Prednisolone Withdrawal in Paediatric Renal Transplantation, 1993
Perineal eruption as an early sign of Kawasaki Disease 1991
Vesicoureteric Reflux and Renal Scarring in Children – A Local Perspective, 1991
Comparison of progression of Renal Failure in Children with Hypoplastic-Dysplastic Kidneys and Chronic Glomerulonephritis, 1991

Research Trials

Principal Investigator : 3 year ( 2010-2013) translational research Grant 09-025 ( BMRC)on Genetics of Innate Immunity, Host Susceptibility and Genetics of Bacterial Virulence in childhood UTI – collaborative study with Singapore Immunology Network (SIgN, A*Star) and Genome Institute of Singapore (GIS)
Co- investigator: Genetic analysis of primary glomerular diseases in children, adolescents and young adults in Asia (KKH Site Primary-investigator, Collaboration with Department of Paediatrics, Paediatric Nephrology Team, National University Hospital, ongoing)
Site Principal Investigator 2010 – 2012 : Phase III multicenter, open label study to evaluate long-term safety and tolerability of Valsartan in children with hypertension with or without chronic renal failure. ( Novartis Grant)
Site Principal Investigator 2008 -2010 : Clinical Phase III multicentre, double blind, randomised, placebo-controlled trial on the efficacy , pharmacokinetics and safety of Alfuzocin 0.2mg/kg/day in the treatment of Neuropathic bladder with hydronephrosis.(Sanofi Grant)
Principal Investigator (2008 – 2010) : Clinical Phase III multicentre, double blind, randomised, placebo-controlled trial on safety and efficacy of Alfuzocin in 2 doses in the treatment of neuropathic bladder (Sanofi Grant)
Co-Investigator. Safety and efficacy of once daily Gentamicin versus thrice daily Gentamicin in the treatment of Childhood UTI. 2000 – 2002.
KKH Grant Site Principal Investigator. (1994 – 1996) Randomized placebo-controlled Double-blind cross-over clinical study on the safety and efficacy of oral DDAVP in Singapore Children with Primary Nocturnal Enuresis. Grant from Ferrings Pharmaceuticals.
Principal Investigator. Longer term outcome of paediatric renal transplantation using Triple immunosuppressive regime. 1991-2 RCH, Melbourne
Principal Investigator UTI Registry 1994-1996. 3-year SingHealth Grant.
Co-Investigator. DMSA scan in childhood UTI and correlation to VUR (Grant from International Atomic Energy Agency). 1998 – 1999

Tags: Paediatric Nephrology, Bedwetting, Congenital Anomalies of the Kidney and Urinary Tract (CAKUT), Fluid and Electrolyte Problems including Tubulopathies, Glomerulonephritis and Glomerular Diseases including Nephrotic Syndrome, Microhaematuria and Proteinuria, Hypertension, Hypertension, Imaging Tests for Urinary Tract Infections (Children), Kidney Biopsy in Children, Kidney Swelling (Hydronephrosis), Nephrotic Syndrome (Children), Reflux Nephropathy, Renal Failure, Urinary Tract Infection (Child), Vesicoureteric Reflux, Voiding Dysfunction including Bedwetting/Nocturnal Enuresis